# HISTORY
23 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.12

# molecular_function
20130308: Eukaryota_PTN000000630 has function peptidyl-prolyl cis-trans isomerase activity (GO:0003755) 
20130308: Eukaryota_PTN000000630 has function protein phosphatase type 2A regulator activity (GO:0008601) 
20130308: Eukaryota_PTN000000630 has function protein tyrosine phosphatase activator activity (GO:0008160) 

# cellular_component
20130308: Eukaryota_PTN000000630 is found in nucleus (GO:0005634) 
20130308: Eukaryota_PTN000000630 is found in cytoplasm (GO:0005737) 
20130308: Eukaryota_PTN000000630 is found in protein phosphatase type 2A complex (GO:0000159) 

# biological_process
20130308: Eukaryota_PTN000000630 participates in mitotic spindle organization in nucleus (GO:0030472) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Members of this family are regulatory subunit of PP2A (protein phosphatase type 2A). This family is well conserved in eukaryotes. There is a single copy in human (PPP2R4, synonym:PTPA) and two copies in yeast (RRD1 and RRD2).
Molecular Function:
1. GO:0008601 protein phosphatase type 2A regulator activity: the human (PPP2R4) and the two yeast genes (RRD1 and RRD2) are annotated to this term. Propagate this term to the root (PTN000000630).
2. GO:0003755 peptidyl-prolyl cis-trans isomerase activity: PTPA (human) (PMID 16380387, see Annotation issues) and RRD1/RRD2 are shown to have this activity. Propagate this term to the root.
3. GO:0008160 protein tyrosine phosphatase activator activity: Human and fly orthologs are annotated to this term but the yeast genes are not. From PMID: 16916641: 'In addition to its serine/threonine phosphatase activity, PP2A exhibits a basal level of phosphotyrosyl phosphatase activity, which is stimulated by a protein with no sequence homology to any known protein. This protein, originally named phosphotyrosyl phosphatase activator (PTPA), is highly conserved from yeast to human and requires ATP/Mg2+ for its activity in vitro'. Despite that currently the two yeast genes are not annotated to this term, I?m propagating this term to the root based on the above statement.
Cellular Component:
1. GO:0000159 protein phosphatase type 2A complex: propagate this term to the root.
2. GO:0005737 cytoplasm: propagate to the root since this annotation is found in both human and at least one yeast copy.
3. GO:0005634 nucleus: propagate to the root since this annotation is found in both human and at least one yeast copy.
Biological Process:
GO:0043666 regulation of phosphoprotein phosphatase activity is a one-step process: it's redundant with (but a lot less informative than) GO:0008601 protein phosphatase type 2A regulator activity. Do not propagate.
1. GO:0030472 mitotic spindle organization in nucleus: Both copies of in yeast (RRD1 and RRD2) are annotated to this term. Since this gene is well conserved across eukaryotes, propagate to the root.
2. GO:000082 G1/S transition of mitotic cell cycle: propagate to the fungi (PTN000797121) based on the annotation to yeast RRD1.
3. GO:0006281 DNA repair: propagate to the fungi (PTN000797121) based on the annotation to yeast RRD1.
Annotation issues:
1.     http://www.uniprot.org/uniprot/Q15257. Currently human PTPA is annotated to GO:0003755 with an IEA evidence code. PMID 16380387 can be used to make an annotation on experimental evidence.
References:
1.         http://www.ncbi.nlm.nih.gov/pubmed?term=16916641
2.         http://www.ncbi.nlm.nih.gov/pubmed?term=16380387
3.         http://www.ncbi.nlm.nih.gov/pubmed/11007961
4.         http://www.biochemj.org/bj/353/0417/bj3530417.htm
Annotated by Donghui Li, with input from Paul Thomas. 03/08/2013.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).