# HISTORY 23 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 # molecular_function 20100922: root_PTN000000001 has function phosphatase activity (GO:0016791) 20100922: node_PTN000000002 has function phosphoserine phosphatase activity (GO:0004647) 20100922: node_PTN000000002 has function magnesium ion binding (GO:0000287) # cellular_component 20140505: root_PTN000000001 is found in cytoplasm (GO:0005737) 20100922: Viridiplantae_PTN000000051 is found in chloroplast (GO:0009507) # biological_process 20140505: root_PTN000000001 participates in small molecule biosynthetic process (GO:0044283) 20100922: node_PTN000000002 participates in L-serine biosynthetic process (GO:0006564) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES . "Fast Pass" curation of PTHR10000: Description of phylogeny - This family consists of one clade of ~45 phosphoserine phosphatases ranging from E. coli serB to human PSPH. - E. coli thrH is annotated to 'threonine biosynthesis' but that seems specific to that protein, see PMID: 10220164 Submitted 22-09-2010 MSL Updated 22-12-2010 MSL Reviewed 05-05-2014 PG # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).