@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (6)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction5563
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0015234 ;
	obo:BFO_0000050 biopax:Pathway1287 ;
	obo:directly_activates biopax:BiochemicalReaction5564 ,
			       biopax:Catalysis2744 ;
	rdfs:label "SLC19A2/3 transport extracellular THMN to cytosol"@em ,
		   "Thiamin transport across the plasma membrane"@em ,
		   "thiamin [extracellular] => thiamin [cytosol]"@em .

biopax:BiochemicalReaction5564
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004788 ;
	obo:BFO_0000050 biopax:Pathway1287 ;
	obo:directly_activates biopax:BiochemicalReaction5565 ,
			       biopax:Catalysis2745 ;
	rdfs:label "2xTPK1:Mg2+ phosphorylates THMN"@em ,
		   "Thiamin is pyrophosphorylated"@em .

biopax:BiochemicalReaction5565
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0050331 ;
	obo:BFO_0000050 biopax:Pathway1287 ;
	obo:directly_activates biopax:BiochemicalReaction5566 ,
			       biopax:Catalysis2746 ;
	rdfs:label "TDPK phosphorylates ThDP to ThTP"@em ,
		   "ThDP + ATP <-> ThTP + ADP"@em .

biopax:BiochemicalReaction5566
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0050333 ;
	obo:BFO_0000050 biopax:Pathway1287 ;
	rdfs:label "THTPA:Mg2+ hydrolyzes ThTP to TDP"@em ,
		   "Thiamin triphosphate can be hydrolysed back to thiamin diphosphate"@em .

biopax:Pathway1287
	a obo:GO_0008150 ;
	rdfs:label "Vitamin B1 (thiamin) metabolism"@em .