@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (17)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P18858
	rdfs:label "LIG1"@em ,
		   "UniProt:P18858 LIG1"@em .

biopax:BiochemicalReaction205
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway81 ;
	obo:directly_activates biopax:BiochemicalReaction206 ;
	rdfs:label "Formation of active Pol II complex with lesioned DNA template"@em .

biopax:BiochemicalReaction206
	a obo:GO_0000716 ;
	obo:BFO_0000050 biopax:Pathway81 ;
	obo:directly_activates biopax:BiochemicalReaction207 ;
	rdfs:label "RNA Pol II is blocked by the lesion leading to reduced transcription"@em .

biopax:BiochemicalReaction207
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway81 ;
	obo:directly_activates biopax:BiochemicalReaction208 ;
	rdfs:label "Assembly of repair proteins at the site of Pol II blockage"@em .

biopax:BiochemicalReaction208
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway82 ;
	obo:directly_activates biopax:BiochemicalReaction209 ,
			       biopax:Catalysis85 ;
	rdfs:label "Displacement of stalled Pol II  from the lesion site"@em .

biopax:BiochemicalReaction209
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004520 ;
	obo:BFO_0000050 biopax:Pathway82 ;
	obo:directly_activates biopax:BiochemicalReaction210 ,
			       biopax:Catalysis86 ;
	rdfs:label "3' incision of the lesioned strand of DNA in TC-NER"@em .

biopax:BiochemicalReaction210
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004520 ;
	obo:BFO_0000050 biopax:Pathway82 ;
	obo:directly_activates biopax:BiochemicalReaction211 ,
			       biopax:BiochemicalReaction212 ,
			       biopax:Catalysis87 ,
			       biopax:Catalysis88 ,
			       biopax:Pathway84 ;
	rdfs:label "5' incision leading to excision of DNA fragment with lesion in TC-NER"@em .

biopax:BiochemicalReaction211
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0003887 ;
	obo:BFO_0000050 biopax:Pathway84 ;
	obo:directly_activates biopax:BiochemicalReaction213 ,
			       biopax:Catalysis89 ;
	rdfs:label "Repair synthesis for gap-filling  by DNA pol delta  in TC-NER"@em .

biopax:BiochemicalReaction212
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0003887 ;
	obo:BFO_0000050 biopax:Pathway84 ;
	obo:directly_activates biopax:BiochemicalReaction213 ,
			       biopax:Catalysis89 ;
	rdfs:label "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER"@em .

biopax:BiochemicalReaction213
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0003909 ;
	obo:BFO_0000050 biopax:Pathway83 ;
	obo:directly_activates biopax:BiochemicalReaction214 ;
	rdfs:label "Ligation of newly synthesized repair patch to incised DNA in TC-NER"@em .

biopax:BiochemicalReaction214
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway80 ;
	rdfs:label "Resumption of transcription after TC-NER"@em .

biopax:Pathway80
	a obo:GO_0008150 ;
	rdfs:label "Transcription-coupled NER (TC-NER)"@em .

biopax:Pathway81
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway80 ;
	rdfs:label "Formation of transcription-coupled NER (TC-NER) repair complex"@em .

biopax:Pathway82
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway80 ;
	rdfs:label "Dual incision reaction in TC-NER"@em .

biopax:Pathway83
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway80 ;
	rdfs:label "Gap-filling DNA repair synthesis and ligation in TC-NER"@em .

biopax:Pathway84
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway83 ;
	rdfs:label "Repair synthesis for gap-filling by DNA polymerase in TC-NER"@em .