CTSS
label: UniProt:P25774 CTSS

TLR folding by chaperones GP96 and CNPY3
type: GO_0003674
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex
type: GO_0003674
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: Full-length TLR3/7/8/9 binds to UNC93B1

Full-length TLR3/7/8/9 binds to UNC93B1
type: GO_0003674
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: Endosomal TLRs pass through the Golgi

Endosomal TLRs pass through the Golgi
type: GO_0003674
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: UNC93B1 delivers endosomal full-length TLRs to endolysosome

UNC93B1 delivers endosomal full-length TLRs to endolysosome
type: GO_0003674
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: TLR processing at low pH
directly activates: TLR9 processing at neutral pH
directly activates: Catalysis324
directly activates: Catalysis325
directly activates: Control53

TLR processing at low pH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0036021
type: GO_0004197
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: BiochemicalReaction972
directly activates: Control68

TLR9 processing at neutral pH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0036021
type: Restriction
  on property: enabled by
  some values from: CTSS
type: GO_0004197
BFO_0000050: Trafficking and processing of endosomal TLR
directly activates: BiochemicalReaction970
directly activates: BiochemicalReaction971
directly activates: Control67

Trafficking and processing of endosomal TLR
type: GO_0008150