@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (18)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_Q9H8X2
	rdfs:label "C9orf12"@em ,
		   "IPPK"@em ,
		   "UniProt:Q9H8X2 IPPK"@em .

biopax:BiochemicalReaction4638
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052825 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4639 ,
			       biopax:Catalysis2045 ;
	rdfs:label "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol"@em .

biopax:BiochemicalReaction4639
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0047325 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4638 ,
			       biopax:BiochemicalReaction4640 ,
			       biopax:BiochemicalReaction4641 ,
			       biopax:BiochemicalReaction4656 ,
			       biopax:Catalysis2044 ,
			       biopax:Catalysis2046 ,
			       biopax:Catalysis2047 ;
	rdfs:label "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol"@em .

biopax:BiochemicalReaction4640
	a [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9H8X2
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0035299 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4644 ,
			       biopax:BiochemicalReaction4646 ,
			       biopax:BiochemicalReaction4653 ,
			       biopax:BiochemicalReaction4657 ,
			       biopax:Catalysis2050 ,
			       biopax:Catalysis2052 ;
	rdfs:label "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol"@em .

biopax:BiochemicalReaction4641
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000827 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4642 ,
			       biopax:BiochemicalReaction4643 ,
			       biopax:Catalysis2048 ,
			       biopax:Catalysis2049 ;
	rdfs:label "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol"@em .

biopax:BiochemicalReaction4642
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052840 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4638 ,
			       biopax:BiochemicalReaction4640 ,
			       biopax:BiochemicalReaction4641 ,
			       biopax:BiochemicalReaction4656 ,
			       biopax:Catalysis2044 ,
			       biopax:Catalysis2046 ,
			       biopax:Catalysis2047 ;
	rdfs:label "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol"@em .

biopax:BiochemicalReaction4643
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052839 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	rdfs:label "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol"@em .

biopax:BiochemicalReaction4644
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000828 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4645 ,
			       biopax:BiochemicalReaction4648 ,
			       biopax:BiochemicalReaction4649 ,
			       biopax:Catalysis2051 ,
			       biopax:Catalysis2054 ,
			       biopax:Catalysis2055 ;
	rdfs:label "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol"@em .

biopax:BiochemicalReaction4645
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052842 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4644 ,
			       biopax:BiochemicalReaction4646 ,
			       biopax:BiochemicalReaction4653 ,
			       biopax:BiochemicalReaction4657 ,
			       biopax:Catalysis2050 ,
			       biopax:Catalysis2052 ;
	rdfs:label "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"@em .

biopax:BiochemicalReaction4646
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000828 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4647 ,
			       biopax:BiochemicalReaction4651 ,
			       biopax:BiochemicalReaction4654 ,
			       biopax:Catalysis2053 ,
			       biopax:Catalysis2057 ;
	rdfs:label "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol"@em .

biopax:BiochemicalReaction4647
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052842 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4644 ,
			       biopax:BiochemicalReaction4646 ,
			       biopax:BiochemicalReaction4653 ,
			       biopax:BiochemicalReaction4657 ,
			       biopax:Catalysis2050 ,
			       biopax:Catalysis2052 ;
	rdfs:label "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"@em .

biopax:BiochemicalReaction4648
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052836 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	rdfs:label "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol"@em .

biopax:BiochemicalReaction4649
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000829 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4650 ,
			       biopax:BiochemicalReaction4652 ,
			       biopax:Catalysis2056 ,
			       biopax:Catalysis2058 ;
	rdfs:label "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol"@em .

biopax:BiochemicalReaction4650
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052841 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4645 ,
			       biopax:BiochemicalReaction4648 ,
			       biopax:BiochemicalReaction4649 ,
			       biopax:Catalysis2051 ,
			       biopax:Catalysis2054 ,
			       biopax:Catalysis2055 ;
	rdfs:label "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol"@em .

biopax:BiochemicalReaction4651
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000829 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4650 ,
			       biopax:BiochemicalReaction4652 ,
			       biopax:Catalysis2056 ,
			       biopax:Catalysis2058 ;
	rdfs:label "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol"@em .

biopax:BiochemicalReaction4652
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052841 ;
	obo:BFO_0000050 biopax:Pathway1139 ;
	obo:directly_activates biopax:BiochemicalReaction4647 ,
			       biopax:BiochemicalReaction4651 ,
			       biopax:BiochemicalReaction4654 ,
			       biopax:Catalysis2053 ,
			       biopax:Catalysis2057 ;
	rdfs:label "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol"@em .

biopax:Pathway1139
	a obo:GO_0008150 ;
	rdfs:label "Synthesis of pyrophosphates in the cytosol"@em .