MG61
PORC
PORCN
PPN
UniProt:Q9H237 PORCN
N-linked glycosylation of WNTs
PORCN palmitoleoylates N-glycosyl WNTs
WNT ligands traffic to the Golgi
WLS binds WNT ligands in the Golgi
WNT ligands traffic to the plasma membrane
secretion of WNT ligands
WLS is endocytosed to the early endosome
Retromer associates with WLS
Retromer recycles WLS to the Golgi
WLS dissociates from retromer
Assembly of the destruction complex
Association of beta-catenin with the destruction complex
Phosphorylation of beta-catenin at Ser45 by CK1 alpha
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
Phosphorylation of APC component of the destruction complex
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex
Multi-ubiquitination of phospho-beta-catenin by SCF-beta-TrCP1
Degradation of ubiquitinated -beta catenin by the proteasome
Signaling by Wnt
WNT ligand biogenesis and trafficking
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade