MG61
label: PORC
label: PORCN
label: PPN
label: UniProt:Q9H237 PORCN

N-linked glycosylation of WNTs
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: PORCN palmitoleoylates N-glycosyl WNTs
directly activates: Catalysis1915

PORCN palmitoleoylates N-glycosyl WNTs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: MG61
type: Restriction
  on property: enabled by
  some values from: MG61
type: GO_0008374
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: WNT ligands traffic to the Golgi
directly activates: Control347

WNT ligands traffic to the Golgi
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: WLS binds WNT ligands in the Golgi

WLS binds WNT ligands in the Golgi
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: WNT ligands traffic to the plasma membrane

WNT ligands traffic to the plasma membrane
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: secretion of WNT ligands

secretion of WNT ligands
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: WLS is endocytosed to the early endosome

WLS is endocytosed to the early endosome
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: Retromer associates with WLS

Retromer associates with WLS
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: Retromer recycles WLS to the Golgi

Retromer recycles WLS to the Golgi
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking
directly activates: WLS dissociates from retromer

WLS dissociates from retromer
type: GO_0003674
BFO_0000050: WNT ligand biogenesis and trafficking

Assembly of the destruction complex
type: GO_0003674
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Association of beta-catenin with the destruction complex

Association of beta-catenin with the destruction complex
type: GO_0003674
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Phosphorylation of beta-catenin at Ser45 by CK1 alpha
directly activates: Catalysis1916

Phosphorylation of beta-catenin at Ser45 by CK1 alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Beta-catenin phosphorylation cascade
directly activates: Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
directly activates: Catalysis1917
directly activates: Control348

Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Beta-catenin phosphorylation cascade
directly activates: Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
directly activates: Catalysis1918
directly activates: Control349

Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Beta-catenin phosphorylation cascade
directly activates: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
directly activates: Catalysis1919
directly activates: Control350

Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Beta-catenin phosphorylation cascade
directly activates: Phosphorylation of APC component of the destruction complex
directly activates: Catalysis1920

Phosphorylation of APC component of the destruction complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex

Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
type: GO_0003674
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex

Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex
type: GO_0003674
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Multi-ubiquitination of phospho-beta-catenin by SCF-beta-TrCP1

Multi-ubiquitination of phospho-beta-catenin by SCF-beta-TrCP1
type: GO_0003674
BFO_0000050: Degradation of beta-catenin by the destruction complex
directly activates: Degradation of ubiquitinated -beta catenin by the proteasome
directly activates: Catalysis1921

Degradation of ubiquitinated -beta catenin by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Degradation of beta-catenin by the destruction complex

Signaling by Wnt
type: GO_0008150

WNT ligand biogenesis and trafficking
type: GO_0008150
BFO_0000050: Signaling by Wnt

Degradation of beta-catenin by the destruction complex
type: GO_0008150
BFO_0000050: Signaling by Wnt

Beta-catenin phosphorylation cascade
type: GO_0008150
BFO_0000050: Degradation of beta-catenin by the destruction complex