Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
NOTCH1 binds DLL1
NOTCH1 binds DLL4
NOTCH1 binds JAG1
NOTCH1 binds JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
NEXT1 is cleaved to produce NICD1
NICD1 traffics to nucleus
DTX binds NOTCH1
Contactin-1 (CNTN1) binds NOTCH1
Cleavage of CNTN1:NOTCH1 complex releases NICD1
NOTCH1 binds DNER
Cleavage of DNER:NOTCH1 complex releases NICD1
DTX recruits beta-arrestin (ARRB) to NOTCH
ARRB mediates NOTCH1 ubiquitination
ITCH binds DTX
ITCH ubiquitinates DTX
NOTCH1 binds DLL/JAG ligand in cis
NOTCH1 binds DLK1
NOTCH1 associates with negative regulators NUMB and ITCH
Ubiquitination of NOTCH1 by ITCH in the absence of ligand
NICD1 displaces co-repressor complex from RBPJ (CSL)
NICD1 in complex with RBPJ (CSL) recruits MAML
HES1 binds TLE
MAML in complex with NICD1 recruits CDK8
NICD1 is phosphorylated by CDK8
Phosphorylated NICD1 binds FBXW7
Ubiquitination of NICD1 by FBWX7
NICD1 binds HIF1A
NOTCH1 HD domain mutants bind DLL1
NOTCH1 HD domain mutants bind DLL4
NOTCH1 HD domain mutants bind JAG1
NOTCH1 HD domain mutants bind JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
NOTCH1 PEST domain mutants bind DLL1
NOTCH1 PEST domain mutants bind DLL4
NOTCH1 PEST domain mutants bind JAG1
NOTCH1 PEST domain mutants bind JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
NICD1 PEST domain mutants translocate from cytosol to nucleus
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
CDK8 phosphorylates NICD1 PEST domain mutants
p-NICD1 PEST domain mutants do not bind FBXW7
NOTCH1 HD+PEST domain mutants bind DLL1
NOTCH1 HD+PEST domain mutants bind DLL4
NOTCH1 HD+PEST domain mutants bind JAG1
NOTCH1 HD+PEST domain mutants bind JAG2
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
FBXW7 WD mutants do not bind NICD1
Signaling by NOTCH1 in Cancer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH1
Activated NOTCH1 Transmits Signal to the Nucleus
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH1 HD Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 HD Domain Mutants
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
NOTCH1 stimulates HES1 transcription
NOTCH1 stimulates MYC transcription
NOTCH1 stimulates HES5 transcription
NOTCH1 stimulates HEY transcription
NOTCH1 PEST domain mutants stimulate HES1 transcription
NOTCH1 PEST domain mutants stimulate HES5 transcription
NOTCH1 PEST domain mutants stimulate HEY transcription
NOTCH1 PEST domain mutants stimulate MYC transcription