Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NEXT1 is cleaved to produce NICD1
directly activates: Catalysis1422

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

NOTCH1 binds DLL1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds DLL4
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds JAG1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

NOTCH1 binds JAG2
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
directly activates: Catalysis1421

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
directly activates: Catalysis557

NEXT1 is cleaved to produce NICD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NICD1 traffics to nucleus

NICD1 traffics to nucleus
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: NICD1 displaces co-repressor complex from RBPJ (CSL)
directly activates: NICD1 binds HIF1A
directly activates: TemplateReaction162
directly activates: TemplateReactionRegulation189
directly activates: TemplateReactionRegulation190

DTX binds NOTCH1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Contactin-1 (CNTN1) binds NOTCH1
directly activates: NOTCH1 binds DNER
directly activates: DTX recruits beta-arrestin (ARRB) to NOTCH

Contactin-1 (CNTN1) binds NOTCH1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Cleavage of CNTN1:NOTCH1 complex releases NICD1
directly activates: Control254

Cleavage of CNTN1:NOTCH1 complex releases NICD1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DNER
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Cleavage of DNER:NOTCH1 complex releases NICD1
directly activates: Control255

Cleavage of DNER:NOTCH1 complex releases NICD1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

DTX recruits beta-arrestin (ARRB) to NOTCH
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: ARRB mediates NOTCH1 ubiquitination
directly activates: Catalysis1423

ARRB mediates NOTCH1 ubiquitination
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

ITCH binds DTX
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: ITCH ubiquitinates DTX
directly activates: Catalysis1424

ITCH ubiquitinates DTX
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DLL/JAG ligand in cis
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 binds DLK1
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NOTCH1 associates with negative regulators NUMB and ITCH
type: GO_0003674
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus
directly activates: Ubiquitination of NOTCH1 by ITCH in the absence of ligand
directly activates: Catalysis1425

Ubiquitination of NOTCH1 by ITCH in the absence of ligand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Activated NOTCH1 Transmits Signal to the Nucleus

NICD1 displaces co-repressor complex from RBPJ (CSL)
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: NICD1 in complex with RBPJ (CSL) recruits MAML

NICD1 in complex with RBPJ (CSL) recruits MAML
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: MAML in complex with NICD1 recruits CDK8
directly activates: NOTCH1 stimulates HES1 transcription
directly activates: NOTCH1 stimulates MYC transcription
directly activates: NOTCH1 stimulates HES5 transcription
directly activates: NOTCH1 stimulates HEY transcription
directly activates: TemplateReactionRegulation51
directly activates: TemplateReactionRegulation52
directly activates: TemplateReactionRegulation53
directly activates: TemplateReactionRegulation54

HES1 binds TLE
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

MAML in complex with NICD1 recruits CDK8
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: NICD1 is phosphorylated by CDK8
directly activates: Catalysis1426

NICD1 is phosphorylated by CDK8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: Phosphorylated NICD1 binds FBXW7

Phosphorylated NICD1 binds FBXW7
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: Ubiquitination of NICD1 by FBWX7
directly activates: Catalysis1427

Ubiquitination of NICD1 by FBWX7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NICD1 binds HIF1A
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NOTCH1 HD domain mutants bind DLL1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

NOTCH1 HD domain mutants bind DLL4
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

NOTCH1 HD domain mutants bind JAG1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

NOTCH1 HD domain mutants bind JAG2
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Constitutive Signaling by NOTCH1 HD Domain Mutants

NOTCH1 PEST domain mutants bind DLL1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants bind DLL4
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants bind JAG1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants bind JAG2
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004190
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NICD1 PEST domain mutants translocate from cytosol to nucleus

NICD1 PEST domain mutants translocate from cytosol to nucleus
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: CDK8 phosphorylates NICD1 PEST domain mutants
directly activates: Catalysis1433

CDK8 phosphorylates NICD1 PEST domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004693
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: p-NICD1 PEST domain mutants do not bind FBXW7

p-NICD1 PEST domain mutants do not bind FBXW7
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

NOTCH1 HD+PEST domain mutants bind DLL1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

NOTCH1 HD+PEST domain mutants bind DLL4
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

NOTCH1 HD+PEST domain mutants bind JAG1
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

NOTCH1 HD+PEST domain mutants bind JAG2
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
directly activates: Catalysis1435

NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008237
BFO_0000050: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
directly activates: NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
directly activates: Catalysis1432

FBXW7 WD mutants do not bind NICD1
type: GO_0003674
BFO_0000050: Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

Signaling by NOTCH1 in Cancer
type: GO_0008150

Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 in Cancer

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Signaling by NOTCH1
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
BFO_0000050: Signaling by NOTCH1 HD Domain Mutants in Cancer
BFO_0000050: Signaling by NOTCH1 PEST Domain Mutants in Cancer
BFO_0000050: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
BFO_0000050: FBXW7 Mutants and NOTCH1 in Cancer

Activated NOTCH1 Transmits Signal to the Nucleus
type: GO_0008150
BFO_0000050: Signaling by NOTCH1

NOTCH1 Intracellular Domain Regulates Transcription
type: GO_0008150
BFO_0000050: Signaling by NOTCH1

Signaling by NOTCH1 HD Domain Mutants in Cancer
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 in Cancer

Constitutive Signaling by NOTCH1 HD Domain Mutants
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 PEST Domain Mutants in Cancer
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 in Cancer

Constitutive Signaling by NOTCH1 PEST Domain Mutants
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 PEST Domain Mutants in Cancer

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 in Cancer

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer

FBXW7 Mutants and NOTCH1 in Cancer
type: GO_0008150
BFO_0000050: Signaling by NOTCH1 in Cancer

Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
type: GO_0008150
BFO_0000050: FBXW7 Mutants and NOTCH1 in Cancer

NOTCH1 stimulates HES1 transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: HES1 binds TLE

NOTCH1 stimulates MYC transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription
directly activates: TemplateReaction33
directly activates: TemplateReactionRegulation49

NOTCH1 stimulates HES5 transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NOTCH1 stimulates HEY transcription
type: GO_0003674
BFO_0000050: NOTCH1 Intracellular Domain Regulates Transcription

NOTCH1 PEST domain mutants stimulate HES1 transcription
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants stimulate HES5 transcription
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants stimulate HEY transcription
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants

NOTCH1 PEST domain mutants stimulate MYC transcription
type: GO_0003674
BFO_0000050: Constitutive Signaling by NOTCH1 PEST Domain Mutants