Ligand-independent dimerization of overexpressed FGFR1
type: GO_0003674
BFO_0000050: Signaling by FGFR1 amplification mutants
directly activates: Ligand-independent phosphorylation of overexpressed FGFR1
directly activates: Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
directly activates: Catalysis1262

Ligand-independent phosphorylation of overexpressed FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR1 amplification mutants
directly activates: Activated FGFR mutants bind FRS2alpha

Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
type: GO_0003674
BFO_0000050: Signaling by FGFR1 amplification mutants

Dimerization of FGFR1 fusion proteins
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Phosphorylation of FGFR1 fusion dimers
directly activates: Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
directly activates: Catalysis1263

Phosphorylation of FGFR1 fusion dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusions bind PLCgamma
directly activates: FGFR1 fusion proteins recruit PIK3R1
directly activates: Phosphorylation of BCR moiety of BCR-FGFR1
directly activates: Phosphorylation of STAT5 by FGFR1 fusions
directly activates: FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
directly activates: Catalysis1266
directly activates: Catalysis1269
directly activates: Catalysis1270

Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 fusions bind PLCgamma
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: PLCgamma is phosphorylated by FGFR1-fusions
directly activates: Catalysis1264

PLCgamma is phosphorylated by FGFR1-fusions
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: p-PLCgamma dissociates from FGFR1 fusions

p-PLCgamma dissociates from FGFR1 fusions
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 fusion proteins recruit PIK3R1
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions

Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
directly activates: Catalysis1265

FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants

Phosphorylation of BCR moiety of BCR-FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: FGFR1 fusion proteins recruit PIK3R1
directly activates: p-BCR-pFGFR1 recruits GRB2:GAB2

p-BCR-pFGFR1 recruits GRB2:GAB2
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: GAB2 is phosphorylated by p-BCR-p-FGFR1
directly activates: The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
directly activates: Catalysis1267

GAB2 is phosphorylated by p-BCR-p-FGFR1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.

Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants

The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
type: GO_0003674
BFO_0000050: Signaling by FGFR1 fusion mutants
directly activates: BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
directly activates: Catalysis1268

BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016301
BFO_0000050: Signaling by FGFR1 fusion mutants

Phosphorylation of STAT5 by FGFR1 fusions
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Signaling by FGFR1 fusion mutants

FGFR1 P252X mutants bind ligand with enhanced affinity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR1
directly activates: Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
directly activates: Catalysis1271

Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR1

Dimerization of FGFR1 point mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR1
directly activates: Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
directly activates: Catalysis1272

Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR1

Dimerization of FGFR2 ligand-independent mutants
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2
directly activates: Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
directly activates: Catalysis1273

Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Activated point mutants of FGFR2

FGFR2b mutants bind an expanded range of ligands
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2
directly activates: Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
directly activates: Catalysis1274
label: FGFR2b somatic mutants bind an expanded range of ligands

Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Activated point mutants of FGFR2

FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2

FGFR2c mutants bind an expanded range of ligands
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2
directly activates: Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
directly activates: Catalysis1275

Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Activated point mutants of FGFR2

Dimerization of FGFR2 point mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2
directly activates: Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
directly activates: Catalysis1276

Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Activated point mutants of FGFR2

Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
type: GO_0003674
BFO_0000050: Activated point mutants of FGFR2

Dimerization of overexpressed FGFR2
type: GO_0003674
BFO_0000050: Signaling by FGFR2 amplification mutants
directly activates: Autocatalytic phosphorylation of overexpressed FGFR2 variants
directly activates: Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
directly activates: Catalysis1277

Autocatalytic phosphorylation of overexpressed FGFR2 variants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR2 amplification mutants

Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
type: GO_0003674
BFO_0000050: Signaling by FGFR2 amplification mutants

GP369 inhibits activation of amplified FGFR2 signaling
type: GO_0003674
BFO_0000050: Signaling by FGFR2 amplification mutants

Constitutive dimerization of FGFR3 cysteine mutants
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3 cysteine mutants
directly activates: Catalysis1278

Autocatalytic phosphorylation of FGFR3 cysteine mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3

Dimerization of FGFR3 point mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
directly activates: Catalysis1279

Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3
label: Autocatalytic phosphorylation of FGFR3 somatic point mutants with enhanced kinase activity

FGFR3c P250R mutant binds to ligand with enhanced affinity
type: GO_0003674
BFO_0000050: Signaling by activated point mutants of FGFR3
directly activates: Autocatalytic phosphorylation of FGFR3c P250R mutant
directly activates: Catalysis1280

Autocatalytic phosphorylation of FGFR3c P250R mutant
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by activated point mutants of FGFR3

Dimerization of FGFR3 t(4;14) translocation mutants
type: GO_0003674
BFO_0000050: t(4;14) translocations of FGFR3

Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: t(4;14) translocations of FGFR3

FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
type: GO_0003674
BFO_0000050: Signaling by FGFR3 mutants

Constitutive dimerization of FGFR4 Y367C mutant
type: GO_0003674
BFO_0000050: Signaling by FGFR4 mutants
directly activates: Autocatalytic phosphorylation of FGFR4 Y367C mutant
directly activates: Catalysis1282

Autocatalytic phosphorylation of FGFR4 Y367C mutant
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR4 mutants

Dimerization of FGFR4 mutants with enhanced kinase activity
type: GO_0003674
BFO_0000050: Signaling by FGFR4 mutants
directly activates: Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
directly activates: FGFR4 kinase mutants are inhibited by PD170734
directly activates: Catalysis1283

Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR4 mutants

FGFR4 kinase mutants are inhibited by PD170734
type: GO_0003674
BFO_0000050: Signaling by FGFR4 mutants

Activated FGFR mutants bind FRS2alpha
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants

FGFR mutants phosphorylate FRS2alpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR mutants
directly activates: GRB2-SOS1 is recruited by activated FGFR mutants
directly activates: GRB2:GAB1:PI3Kreg binds to p-FRS2:activated FGFR mutants

GRB2-SOS1 is recruited by activated FGFR mutants
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants
directly activates: Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants
directly activates: Catalysis1285

Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005088
BFO_0000050: Signaling by FGFR mutants

GRB2:GAB1:PI3Kreg binds to p-FRS2:activated FGFR mutants
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants
directly activates: Recruitment of the catalytic subunit of PI3K by activated FGFR1 mutants

Recruitment of the catalytic subunit of PI3K by activated FGFR1 mutants
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants
directly activates: Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants
directly activates: Catalysis1286

Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016301
BFO_0000050: Signaling by FGFR mutants

Activated FGFR mutants bind PLC-gamma
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants
directly activates: PLC-gamma phosphorylation by FGFR mutants
directly activates: Catalysis1287

PLC-gamma phosphorylation by FGFR mutants
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Signaling by FGFR mutants
directly activates: Activated PLC-gamma release by activated FGFR mutants

Activated PLC-gamma release by activated FGFR mutants
type: GO_0003674
BFO_0000050: Signaling by FGFR mutants

Signaling by FGFR mutants
type: GO_0008150

Signaling by FGFR1 mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR mutants

Signaling by FGFR1 amplification mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants

Signaling by FGFR1 fusion mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants

Signaling by activated point mutants of FGFR1
type: GO_0008150
BFO_0000050: Signaling by FGFR1 mutants

Signaling by FGFR2 mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR mutants

Activated point mutants of FGFR2
type: GO_0008150
BFO_0000050: Signaling by FGFR2 mutants

Signaling by FGFR2 amplification mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR2 mutants

Signaling by FGFR3 mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR mutants

Signaling by activated point mutants of FGFR3
type: GO_0008150
BFO_0000050: Signaling by FGFR3 mutants

t(4;14) translocations of FGFR3
type: GO_0008150
BFO_0000050: Signaling by FGFR3 mutants

Signaling by FGFR4 mutants
type: GO_0008150
BFO_0000050: Signaling by FGFR mutants