Ligand-independent dimerization of overexpressed FGFR1
Ligand-independent phosphorylation of overexpressed FGFR1
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers
Dimerization of FGFR1 fusion proteins
Phosphorylation of FGFR1 fusion dimers
Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation
FGFR1 fusions bind PLCgamma
PLCgamma is phosphorylated by FGFR1-fusions
p-PLCgamma dissociates from FGFR1 fusions
FGFR1 fusion proteins recruit PIK3R1
Recruitment of the catalytic subunit of PI3K to activated FGFR1 fusions
FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
Phosphorylation of BCR moiety of BCR-FGFR1
p-BCR-pFGFR1 recruits GRB2:GAB2
GAB2 is phosphorylated by p-BCR-p-FGFR1
Recruitment of the p85 regulatory subunit of PI3K to the BCR-FGFR1 complex.
The catalytic subunit of PI3K is recruited to the BCR-FGFR1 fusion.
BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
Phosphorylation of STAT5 by FGFR1 fusions
FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3
FGFR1 P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1 P252X mutant dimers
Dimerization of FGFR1 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
Dimerization of FGFR2 ligand-independent mutants
Autocatalytic phosphorylation of FGFR2 ligand-independent mutants
FGFR2b mutants bind an expanded range of ligands
FGFR2b somatic mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
FGFR2c mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
Dimerization of FGFR2 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
Dimerization of overexpressed FGFR2
Autocatalytic phosphorylation of overexpressed FGFR2 variants
Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
GP369 inhibits activation of amplified FGFR2 signaling
Constitutive dimerization of FGFR3 cysteine mutants
Autocatalytic phosphorylation of FGFR3 cysteine mutants
Dimerization of FGFR3 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR3 somatic point mutants with enhanced kinase activity
FGFR3c P250R mutant binds to ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR3c P250R mutant
Dimerization of FGFR3 t(4;14) translocation mutants
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
Constitutive dimerization of FGFR4 Y367C mutant
Autocatalytic phosphorylation of FGFR4 Y367C mutant
Dimerization of FGFR4 mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
FGFR4 kinase mutants are inhibited by PD170734
Activated FGFR mutants bind FRS2alpha
FGFR mutants phosphorylate FRS2alpha
GRB2-SOS1 is recruited by activated FGFR mutants
Ras nucleotide exchange mediated by GRB2-SOS1 bound to FGFR mutants
GRB2:GAB1:PI3Kreg binds to p-FRS2:activated FGFR mutants
Recruitment of the catalytic subunit of PI3K by activated FGFR1 mutants
Conversion of PIP2 to PIP3 by PI3K associated with FGFR mutants
Activated FGFR mutants bind PLC-gamma
PLC-gamma phosphorylation by FGFR mutants
Activated PLC-gamma release by activated FGFR mutants
Signaling by FGFR mutants
Signaling by FGFR1 mutants
Signaling by FGFR1 amplification mutants
Signaling by FGFR1 fusion mutants
Signaling by activated point mutants of FGFR1
Signaling by FGFR2 mutants
Activated point mutants of FGFR2
Signaling by FGFR2 amplification mutants
Signaling by FGFR3 mutants
Signaling by activated point mutants of FGFR3
t(4;14) translocations of FGFR3
Signaling by FGFR4 mutants