@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (17)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction4091
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "The ligand trap binds the ligand BMP2, blocking BMP signalling"@em .

biopax:BiochemicalReaction4092
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4093 ,
			       biopax:Catalysis1850 ;
	rdfs:label "Formation of a heteromeric BMP receptor complex"@em .

biopax:BiochemicalReaction4093
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0005160 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4094 ,
			       biopax:Catalysis1851 ;
	rdfs:label "BMP2 binds to the receptor complex"@em .

biopax:BiochemicalReaction4094
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0016362 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4095 ,
			       biopax:BiochemicalReaction4096 ;
	rdfs:label "Type II receptor phosphorylates type I receptor"@em .

biopax:BiochemicalReaction4095
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4097 ,
			       biopax:Catalysis1853 ;
	rdfs:label "An anchoring protein, Endofin, recruits R-Smad1/5/8"@em .

biopax:BiochemicalReaction4096
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated"@em .

biopax:BiochemicalReaction4097
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004675 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4098 ;
	rdfs:label "Activated type I receptor phosphorylates R-Smad1/5/8 directly"@em .

biopax:BiochemicalReaction4098
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4099 ,
			       biopax:BiochemicalReaction4100 ;
	rdfs:label "Phospho-R-Smad1/5/8 dissociates from the receptor complex"@em .

biopax:BiochemicalReaction4099
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "I-Smad competes with Co-Smad for R-Smad1/5/8"@em .

biopax:BiochemicalReaction4100
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:BiochemicalReaction4101 ;
	rdfs:label "Phospho-R-Smad1/5/8 forms a complex with Co-Smad"@em .

biopax:BiochemicalReaction4101
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	obo:directly_activates biopax:Catalysis1854 ,
			       biopax:Degradation13 ;
	rdfs:label "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus"@em .

biopax:BiochemicalReaction4102
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "SKI complexes with the Smad complex, suppressing BMP2 signalling"@em .

biopax:BiochemicalReaction4103
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "I-Smad competes with R-Smad1/5/8 for type I receptor"@em .

biopax:Degradation12
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8"@em .

biopax:Degradation13
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway1044 ;
	rdfs:label "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling"@em .

biopax:Pathway1044
	a obo:GO_0008150 ;
	rdfs:label "Signaling by BMP"@em .