@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (49)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P53350
	rdfs:label "PLK"@em ,
		   "PLK1"@em ,
		   "UniProt:P53350 PLK1"@em .

biopax:BiochemicalReaction1866
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway437 ;
	rdfs:label "Inactivation of APC/C via CDC20 sequestration"@em .

biopax:BiochemicalReaction1867
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway438 ;
	obo:directly_activates biopax:BiochemicalReaction1868 ;
	rdfs:label "Formation of the MCC complex"@em .

biopax:BiochemicalReaction1868
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway438 ;
	obo:directly_activates biopax:BiochemicalReaction2028 ,
			       biopax:BiochemicalReaction2520 ,
			       biopax:BiochemicalReaction3794 ;
	rdfs:label "Binding of the MCC complex to the APC/C complex"@em .

biopax:BiochemicalReaction1999
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway500 ;
	obo:directly_activates biopax:BiochemicalReaction2000 ,
			       biopax:Catalysis895 ;
	rdfs:label "Association of Securin with Cdc20:APC/C complex"@em .

biopax:BiochemicalReaction2000
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ,
	  obo:GO_0042787 ;
	obo:BFO_0000050 biopax:Pathway500 ;
	obo:directly_activates biopax:BiochemicalReaction2001 ,
			       biopax:Catalysis896 ;
	rdfs:label "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"@em .

biopax:BiochemicalReaction2001
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway500 ;
	obo:directly_activates biopax:BiochemicalReaction2003 ,
			       biopax:BiochemicalReaction2033 ,
			       biopax:Catalysis897 ;
	rdfs:label "Degradation of multiubiquitinated Securin"@em .

biopax:BiochemicalReaction2015
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	obo:directly_activates biopax:BiochemicalReaction2016 ,
			       biopax:Catalysis904 ;
	rdfs:label "Association of Cyclin A:Cdk2 with Cdh1"@em .

biopax:BiochemicalReaction2016
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ,
	  obo:GO_0051436 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	obo:directly_activates biopax:BiochemicalReaction2017 ,
			       biopax:BiochemicalReaction2032 ,
			       biopax:Catalysis913 ;
	rdfs:label "Phosphorylation of Cdh1 by Cyclin A:Cdk2"@em .

biopax:BiochemicalReaction2017
	a obo:GO_0051436 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	rdfs:label "Dissociation of phospho-Cdh1 from the APC/C complex"@em .

biopax:BiochemicalReaction2018
	a obo:GO_0051436 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	obo:directly_activates biopax:BiochemicalReaction2020 ,
			       biopax:BiochemicalReaction2021 ,
			       biopax:Catalysis905 ,
			       biopax:Catalysis906 ,
			       biopax:Pathway494 ;
	rdfs:label "Association of Emi1 with Cdh1"@em .

biopax:BiochemicalReaction2019
	a obo:GO_0051436 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	obo:directly_activates biopax:BiochemicalReaction2020 ,
			       biopax:BiochemicalReaction2021 ,
			       biopax:Catalysis905 ,
			       biopax:Catalysis906 ,
			       biopax:Pathway494 ;
	rdfs:label "Association of Emi1 with Cdc20"@em .

biopax:BiochemicalReaction2020
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway494 ;
	obo:directly_activates biopax:BiochemicalReaction2022 ;
	rdfs:label "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2"@em .

biopax:BiochemicalReaction2021
	a [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway494 ;
	obo:directly_activates biopax:BiochemicalReaction2022 ;
	rdfs:label "Phosphorylation of the Emi1 DSGxxS degron by Plk1"@em .

biopax:BiochemicalReaction2022
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway495 ;
	obo:directly_activates biopax:BiochemicalReaction2023 ,
			       biopax:Catalysis907 ;
	rdfs:label "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex"@em .

biopax:BiochemicalReaction2023
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway495 ;
	obo:directly_activates biopax:BiochemicalReaction2024 ,
			       biopax:Catalysis908 ;
	rdfs:label "Ubiquitination of Emi1 by SCF-beta-TrCP"@em .

biopax:BiochemicalReaction2024
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway495 ;
	obo:directly_activates biopax:BiochemicalReaction2025 ,
			       biopax:Catalysis909 ;
	rdfs:label "SCF-mediated degradation of Emi1"@em .

biopax:BiochemicalReaction2025
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ,
	  obo:GO_0051436 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	obo:directly_activates biopax:BiochemicalReaction2032 ,
			       biopax:Catalysis913 ;
	rdfs:label "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"@em .

biopax:BiochemicalReaction2026
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P53350
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway497 ;
	rdfs:label "Free APC/C phosphorylated by Plk1"@em .

biopax:BiochemicalReaction2027
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway497 ;
	rdfs:label "Free APC/C phosphorylated by Cyclin B:Cdc2"@em .

biopax:BiochemicalReaction2028
	a obo:GO_0051437 ;
	obo:BFO_0000050 biopax:Pathway498 ;
	obo:directly_activates biopax:BiochemicalReaction1999 ,
			       biopax:BiochemicalReaction2029 ;
	rdfs:label "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"@em .

biopax:BiochemicalReaction2029
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway499 ;
	obo:directly_activates biopax:BiochemicalReaction2030 ,
			       biopax:Catalysis912 ;
	rdfs:label "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex"@em .

biopax:BiochemicalReaction2030
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ,
	  obo:GO_0042787 ;
	obo:BFO_0000050 biopax:Pathway499 ;
	obo:directly_activates biopax:BiochemicalReaction2031 ;
	rdfs:label "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"@em .

biopax:BiochemicalReaction2031
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway499 ;
	obo:directly_activates biopax:BiochemicalReaction2033 ;
	rdfs:label "Degradation of multiubiquitinated Cyclin B"@em .

biopax:BiochemicalReaction2032
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004721 ;
	obo:BFO_0000050 biopax:Pathway501 ;
	obo:directly_activates biopax:BiochemicalReaction2034 ;
	rdfs:label "Dephosphorylation of phospho-Cdh1"@em .

biopax:BiochemicalReaction2033
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway501 ;
	obo:directly_activates biopax:BiochemicalReaction2034 ;
	rdfs:label "Dissociation of Cdc20 from APC/C complex"@em .

biopax:BiochemicalReaction2034
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway501 ;
	obo:directly_activates biopax:BiochemicalReaction2035 ;
	rdfs:label "Association of Cdh1 with the APC/C"@em .

biopax:BiochemicalReaction2035
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway502 ;
	obo:directly_activates biopax:BiochemicalReaction2036 ,
			       biopax:Catalysis914 ;
	rdfs:label "Association of cell cycle proteins with the APC/C:Cdh1 complex"@em .

biopax:BiochemicalReaction2036
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ,
	  obo:GO_0042787 ;
	obo:BFO_0000050 biopax:Pathway502 ;
	obo:directly_activates biopax:BiochemicalReaction2037 ,
			       biopax:BiochemicalReaction2039 ,
			       biopax:Catalysis915 ,
			       biopax:Catalysis917 ;
	rdfs:label "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"@em .

biopax:BiochemicalReaction2037
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway502 ;
	rdfs:label "Degradation of multiubiquitinated cell cycle proteins"@em .

biopax:BiochemicalReaction2038
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway502 ;
	rdfs:label "APC/C:Cdh1-mediated degradation of Skp2"@em .

biopax:BiochemicalReaction2039
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004842 ,
	  obo:GO_0042787 ;
	obo:BFO_0000050 biopax:Pathway503 ;
	obo:directly_activates biopax:BiochemicalReaction2040 ,
			       biopax:Catalysis918 ;
	rdfs:label "Multiubiquitination of APC/C-associated Cdh1"@em .

biopax:BiochemicalReaction2040
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway503 ;
	rdfs:label "Degradation of multiubiquitinated Cdh1"@em .

biopax:Pathway437
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	rdfs:label "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"@em .

biopax:Pathway438
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway437 ;
	rdfs:label "Inactivation of APC/C via direct inhibition of the APC/C complex"@em .

biopax:Pathway491
	a obo:GO_0008150 ;
	rdfs:label "Regulation of mitotic cell cycle"@em .

biopax:Pathway492
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway491 ;
	rdfs:label "APC/C-mediated degradation of cell cycle proteins"@em .

biopax:Pathway493
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway492 ;
	rdfs:label "Regulation of APC/C activators between G1/S and early anaphase"@em .

biopax:Pathway494
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	rdfs:label "Phosphorylation of Emi1"@em .

biopax:Pathway495
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway493 ;
	rdfs:label "SCF-beta-TrCP mediated degradation of Emi1"@em .

biopax:Pathway496
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway492 ;
	rdfs:label "Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins"@em .

biopax:Pathway497
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway496 ;
	rdfs:label "Phosphorylation of the APC/C"@em .

biopax:Pathway498
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway496 ;
	rdfs:label "APC/C:Cdc20 mediated degradation of mitotic proteins"@em .

biopax:Pathway499
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway498 ;
	rdfs:label "APC/C:Cdc20 mediated degradation of Cyclin B"@em .

biopax:Pathway500
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway498 ;
	rdfs:label "APC/C:Cdc20 mediated degradation of Securin"@em .

biopax:Pathway501
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway492 ;
	rdfs:label "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"@em .

biopax:Pathway502
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway492 ;
	rdfs:label "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"@em .

biopax:Pathway503
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway492 ;
	rdfs:label "Autodegradation of Cdh1 by Cdh1:APC/C"@em .