@prefix owl: . @prefix rdfs: . @prefix rdf: . @prefix biopax: . @prefix obo: . # Named toplevel resources (41) a owl:Ontology ; owl:imports , . obo:UniProtKB_Q09428 rdfs:label "ABCC8"@em , "HRINS"@em , "SUR"@em , "SUR1"@em , "UniProt:Q09428 ABCC8"@em . biopax:BiochemicalReaction1769 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction1770 , biopax:BiochemicalReaction5338 ; rdfs:label "Rearrangement of the heterotrimeric G(s) complex"@em . biopax:BiochemicalReaction4325 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction4341 , biopax:BiochemicalReaction5337 ; rdfs:label "Binding of Glucagon-like Peptide-1 by Glucagon-like Peptide-1 Receptor"@em . biopax:BiochemicalReaction4418 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1244 ; obo:directly_activates biopax:BiochemicalReaction5334 , biopax:Catalysis2568 , biopax:TemplateReaction109 ; rdfs:label "Activation of Protein kinase C, alpha type by Diacylglycerol"@em . biopax:BiochemicalReaction5323 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; obo:directly_activates biopax:BiochemicalReaction5324 , biopax:Control418 ; rdfs:label "Binding of Adrenaline or Noradrenaline by Alpha-2A/2C Adrenergic Receptors"@em . biopax:BiochemicalReaction5324 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; obo:directly_activates biopax:BiochemicalReaction5325 ; rdfs:label "Activation of Gi/o Heterotrimeric G Proteins by Alpha Adrenergic Receptors Alpha-2A/2C"@em . biopax:BiochemicalReaction5325 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; obo:directly_activates biopax:BiochemicalReaction5326 , biopax:BiochemicalReaction5327 , biopax:BiochemicalReaction5328 , biopax:Control419 , biopax:Control420 ; rdfs:label "Dissociation of Gi/o Heterotrimeric G-protein Complex"@em . biopax:BiochemicalReaction5326 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; rdfs:label "Closing (Inhibition) of L-type Calcium Channels in Pancreatic Beta Cells"@em . biopax:BiochemicalReaction5327 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; rdfs:label "Opening of Potassium Channels in Pancreatic Beta Cells in Response to Epinephrine"@em . biopax:BiochemicalReaction5328 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1243 ; rdfs:label "Inhibition of Adenylate Cyclase by G-beta:G-gamma"@em . biopax:BiochemicalReaction5329 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1244 ; obo:directly_activates biopax:BiochemicalReaction5330 , biopax:Catalysis2566 ; rdfs:label "Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3"@em . biopax:BiochemicalReaction5330 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0005085 ; obo:BFO_0000050 biopax:Pathway1244 ; obo:directly_activates biopax:BiochemicalReaction5331 ; rdfs:label "Activation of Gq by Muscarinic Acetylcholine Receptor M3"@em . biopax:BiochemicalReaction5331 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1244 , biopax:Pathway1246 ; obo:directly_activates biopax:BiochemicalReaction5332 ; rdfs:label "Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex"@em . biopax:BiochemicalReaction5332 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1244 , biopax:Pathway1246 ; obo:directly_activates biopax:BiochemicalReaction5333 , biopax:Catalysis2567 ; rdfs:label "Activation of Phospholipase C Beta by Gq alpha"@em . biopax:BiochemicalReaction5333 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004629 ; obo:BFO_0000050 biopax:Pathway1244 , biopax:Pathway1246 ; obo:directly_activates biopax:BiochemicalReaction4418 , biopax:BiochemicalReaction715 ; rdfs:label "Hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate by Activated Phospholipase C Beta-1"@em . biopax:BiochemicalReaction5334 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004674 ; obo:BFO_0000050 biopax:Pathway1244 ; rdfs:label "Phosphorylation of MARCKS by Protein kinase C, alpha type"@em . biopax:BiochemicalReaction5335 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1246 ; obo:directly_activates biopax:BiochemicalReaction5336 , biopax:Catalysis2569 ; rdfs:label "Binding of fatty acid ligands by Free fatty acid receptor 1 (GPR40)"@em . biopax:BiochemicalReaction5336 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0005085 ; obo:BFO_0000050 biopax:Pathway1246 ; obo:directly_activates biopax:BiochemicalReaction5331 ; rdfs:label "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex"@em . biopax:BiochemicalReaction5337 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction1769 ; rdfs:label "Activation of G(s) by GLP-1R"@em . biopax:BiochemicalReaction5338 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5339 , biopax:Catalysis2570 ; rdfs:label "Activation of Adenylyl Cyclase by G(s):GTP"@em . biopax:BiochemicalReaction5339 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004016 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5340 , biopax:BiochemicalReaction5343 , biopax:BiochemicalReaction5344 ; rdfs:label "Production of Cyclic AMP by Activated Adenylyl Cyclase"@em . biopax:BiochemicalReaction5340 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5341 , biopax:BiochemicalReaction5342 , biopax:BiochemicalReaction5348 , biopax:Catalysis2573 , biopax:Control421 , biopax:Control422 , biopax:Control425 , biopax:Control426 , biopax:Control427 ; rdfs:label "cAMP induces dissociation of active PKA catalytic subunits from the PKA:AKAP79:IQGAP1 Complex"@em . biopax:BiochemicalReaction5341 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5349 , biopax:Catalysis2574 ; rdfs:label "Closing of Potassium voltage-gated channels by PKA"@em . biopax:BiochemicalReaction5342 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5350 , biopax:Catalysis2575 , biopax:Control428 , biopax:Control429 , biopax:Control430 , biopax:Control431 ; rdfs:label "Opening of ER calcium channels by activated PKA"@em . biopax:BiochemicalReaction5343 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5345 , biopax:Control423 , biopax:Control424 ; rdfs:label "Activation of Epac1 by cAMP"@em . biopax:BiochemicalReaction5344 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; obo:directly_activates biopax:BiochemicalReaction5345 , biopax:Control423 , biopax:Control424 ; rdfs:label "Activation of Epac2 by cAMP"@em . biopax:BiochemicalReaction5345 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1247 ; rdfs:label "Exchange of GDP for GTP by Rap1A"@em . biopax:BiochemicalReaction5346 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0005355 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2"@em . biopax:BiochemicalReaction5347 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005743 ] , obo:GO_0015207 ; obo:BFO_0000050 biopax:Pathway1242 ; obo:directly_activates biopax:BiochemicalReaction5348 , biopax:BiochemicalReaction5430 , biopax:Catalysis2573 , biopax:Control425 , biopax:Control426 , biopax:Control427 ; rdfs:label "ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix"@em . biopax:BiochemicalReaction5348 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:enabled_by ; owl:someValuesFrom obo:UniProtKB_Q09428 ] , obo:GO_0005524 ; obo:BFO_0000050 biopax:Pathway1242 ; obo:directly_activates biopax:BiochemicalReaction5349 , biopax:Catalysis2574 ; rdfs:label "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)"@em . biopax:BiochemicalReaction5349 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0005245 ; obo:BFO_0000050 biopax:Pathway1242 ; obo:directly_activates biopax:BiochemicalReaction5350 , biopax:Catalysis2575 , biopax:Control428 , biopax:Control429 , biopax:Control430 , biopax:Control431 ; rdfs:label "Calcium Influx through Voltage-gated Calcium Channels"@em . biopax:BiochemicalReaction5350 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0000149 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Exocytosis of Insulin"@em . biopax:BiochemicalReaction715 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway1242 ; obo:directly_activates biopax:BiochemicalReaction716 , biopax:Catalysis272 , biopax:Control50 ; rdfs:label "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel"@em . biopax:BiochemicalReaction716 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005789 ] , obo:GO_0005261 ; obo:BFO_0000050 biopax:Pathway1242 ; obo:directly_activates biopax:BiochemicalReaction242 , biopax:BiochemicalReaction5350 , biopax:BiochemicalReaction717 , biopax:BiochemicalReaction722 , biopax:Catalysis2575 , biopax:Catalysis273 , biopax:Control428 , biopax:Control429 , biopax:Control430 , biopax:Control431 , biopax:Pathway1104 ; rdfs:label "Release of calcium from intracellular stores by IP3 receptor activation"@em . biopax:Pathway1242 a obo:GO_0008150 ; rdfs:label "Regulation of Insulin Secretion"@em . biopax:Pathway1243 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Inhibition of Insulin Secretion by Adrenaline/Noradrenaline"@em . biopax:Pathway1244 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Regulation of Insulin Secretion by Acetylcholine"@em . biopax:Pathway1245 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Regulation of Insulin Secretion by Free Fatty Acids"@em . biopax:Pathway1246 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway1245 ; rdfs:label "Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)"@em . biopax:Pathway1247 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway1242 ; rdfs:label "Regulation of Insulin Secretion by Glucagon-like Peptide-1"@em .