@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (20)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction11
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway22 ;
	obo:directly_activates biopax:BiochemicalReaction12 ,
			       biopax:BiochemicalReaction13 ,
			       biopax:Catalysis3 ;
	rdfs:label "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1"@em .

biopax:BiochemicalReaction16
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway23 ;
	obo:directly_activates biopax:BiochemicalReaction50 ;
	rdfs:label "Cdt1 is displaced from the pre-replicative complex."@em .

biopax:BiochemicalReaction25
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway12 ;
	obo:directly_activates biopax:BiochemicalReaction26 ;
	rdfs:label "Orc1 is phosphorylated by cyclin A/CDK2"@em .

biopax:BiochemicalReaction26
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway12 ;
	obo:directly_activates biopax:BiochemicalReaction27 ;
	rdfs:label "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin"@em .

biopax:BiochemicalReaction27
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway12 ;
	obo:directly_activates biopax:BiochemicalReaction28 ,
			       biopax:Catalysis8 ;
	rdfs:label "Ubiquitinated Orc1 enters the cytosol"@em .

biopax:BiochemicalReaction28
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway12 ;
	rdfs:label "Ubiquitinated Orc1 is degraded by the proteasome"@em .

biopax:BiochemicalReaction29
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway13 ;
	obo:directly_activates biopax:BiochemicalReaction30 ;
	rdfs:label "Cdc6 protein is phosphorylated by CDK"@em .

biopax:BiochemicalReaction30
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway13 ;
	obo:directly_activates biopax:BiochemicalReaction31 ,
			       biopax:Catalysis10 ;
	rdfs:label "Phosphorylated Cdc6 is exported from the nucleus"@em .

biopax:BiochemicalReaction31
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway13 ;
	obo:directly_activates biopax:BiochemicalReaction32 ,
			       biopax:Catalysis11 ;
	rdfs:label "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex"@em .

biopax:BiochemicalReaction32
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway13 ;
	rdfs:label "Ubiquitinated Cdc6 is degraded by the proteasome"@em .

biopax:BiochemicalReaction33
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway23 ;
	rdfs:label "Mcm4,6,7 trimer forms and associates with the replication fork"@em ,
		   "Rearrangement and mobilization of Mcm2-7"@em .

biopax:BiochemicalReaction50
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway23 ;
	rdfs:label "Cdt1 associates with geminin"@em .

biopax:BiochemicalReaction7
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway22 ;
	obo:directly_activates biopax:BiochemicalReaction8 ;
	rdfs:label "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes"@em .

biopax:Pathway12
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway23 ;
	rdfs:label "Orc1 removal from chromatin"@em .

biopax:Pathway13
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway23 ;
	rdfs:label "CDK-mediated phosphorylation and removal of Cdc6"@em .

biopax:Pathway21
	a obo:GO_0008150 ;
	rdfs:label "Regulation of DNA replication"@em .

biopax:Pathway22
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway21 ;
	rdfs:label "Association of licensing factors with the pre-replicative complex"@em .

biopax:Pathway23
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway21 ;
	rdfs:label "Removal of licensing factors from origins"@em .

biopax:TemplateReaction1
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway22 ;
	obo:directly_activates biopax:BiochemicalReaction10 ;
	rdfs:label "CDC6 protein is synthesized under the control of E2F transcription factors"@em .