@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (7)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction3906
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0008237 ;
	obo:BFO_0000050 biopax:Pathway1003 ;
	obo:directly_activates biopax:BiochemicalReaction3907 ;
	rdfs:label "alpha-secretase cleaves the p75NTR extracellular domain"@em .

biopax:BiochemicalReaction3907
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1003 ;
	obo:directly_activates biopax:BiochemicalReaction3908 ,
			       biopax:Catalysis1780 ;
	rdfs:label "The p75NTR C-terminal fragment enters endosomes"@em .

biopax:BiochemicalReaction3908
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway1003 ;
	obo:directly_activates biopax:BiochemicalReaction3909 ,
			       biopax:BiochemicalReaction3910 ;
	rdfs:label "gamma-secretase cleaves the p75NTR transmembrane domain"@em .

biopax:BiochemicalReaction3909
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1003 ;
	rdfs:label "p75NTR ICD signals to NF-kB"@em .

biopax:BiochemicalReaction3910
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1003 ;
	rdfs:label "Part of the ICD migrates to the nucleus"@em .

biopax:Pathway1003
	a obo:GO_0008150 ;
	rdfs:label "Regulated proteolysis of p75NTR"@em .