@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (12)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P05108
	rdfs:label "CYP11A"@em ,
		   "CYP11A1"@em ,
		   "UniProt:P05108 CYP11A1"@em .

obo:UniProtKB_P15121
	rdfs:label "AKR1B1"@em ,
		   "ALDR1"@em ,
		   "UniProt:P15121 AKR1B1"@em .

biopax:BiochemicalReaction2550
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2551 ;
	rdfs:label "Cholesterol translocates to the inner mitochondrial membrane"@em .

biopax:BiochemicalReaction2551
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2552 ,
			       biopax:Catalysis1098 ;
	rdfs:label "Cholesterol is released into the inner mitochondrial membrane"@em .

biopax:BiochemicalReaction2552
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005759
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P05108
	  ] ,
	  obo:GO_0008386 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2553 ,
			       biopax:Catalysis1099 ;
	rdfs:label "Oxidation of cholesterol"@em ,
		   "Oxidation of cholesterol to 22beta-hydroxycholesterol"@em ,
		   "cholesterol + NADPH + H+ => 22beta-hydroxycholesterol + NADP+ + H2O"@em .

biopax:BiochemicalReaction2553
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005759
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P05108
	  ] ,
	  obo:GO_0008386 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2554 ,
			       biopax:Catalysis1100 ;
	rdfs:label "22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O"@em ,
		   "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol"@em .

biopax:BiochemicalReaction2554
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005759
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P05108
	  ] ,
	  obo:GO_0008386 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2555 ,
			       biopax:BiochemicalReaction2557 ;
	rdfs:label "20alpha,22beta-hydroxycholesterol + NADPH + H+ + O2 => pregnenolone + isocaproaldehyde + NADP+ + H2O"@em ,
		   "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde"@em .

biopax:BiochemicalReaction2555
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2556 ,
			       biopax:Catalysis1101 ;
	rdfs:label "Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol"@em .

biopax:BiochemicalReaction2556
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P15121
	  ] ,
	  obo:GO_0004032 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	rdfs:label "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"@em ,
		   "isocaproaldehyde + NADPH + H+ => 4-methylpentan-1-ol + NADP+"@em .

biopax:BiochemicalReaction2557
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway581 ;
	obo:directly_activates biopax:BiochemicalReaction2558 ,
			       biopax:BiochemicalReaction2566 ,
			       biopax:Catalysis1102 ,
			       biopax:Catalysis1108 ;
	rdfs:label "Pregnenolone translocates from the mitochondrial matrix to the cytosol"@em .

biopax:Pathway581
	a obo:GO_0008150 ;
	rdfs:label "Pregnenolone biosynthesis"@em .