@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (69)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_Q6XPS3
	rdfs:label "TPIP"@em ,
		   "TPTE2"@em ,
		   "UniProt:Q6XPS3 TPTE2"@em .

obo:UniProtKB_Q9NTJ5
	rdfs:label "KIAA0851"@em ,
		   "SACM1L"@em ,
		   "UniProt:Q9NTJ5 SACM1L"@em .

biopax:BiochemicalReaction5050
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1201 ;
	obo:directly_activates biopax:BiochemicalReaction5051 ;
	rdfs:label "PI:PITPNB is transported from the ER membrane to the Golgi membrane"@em .

biopax:BiochemicalReaction5051
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1201 ;
	obo:directly_activates biopax:BiochemicalReaction5052 ,
			       biopax:BiochemicalReaction5115 ,
			       biopax:BiochemicalReaction5117 ,
			       biopax:BiochemicalReaction5119 ,
			       biopax:Catalysis2389 ,
			       biopax:Catalysis2390 ,
			       biopax:Catalysis2392 ;
	rdfs:label "PI is exchanged with PC by PITPNB"@em .

biopax:BiochemicalReaction5052
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1201 ;
	obo:directly_activates biopax:BiochemicalReaction5053 ;
	rdfs:label "PC:PITPNB is transported from the Golgi membrane to the ER membrane"@em .

biopax:BiochemicalReaction5053
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1201 ;
	obo:directly_activates biopax:BiochemicalReaction5018 ,
			       biopax:BiochemicalReaction5050 ,
			       biopax:BiochemicalReaction5054 ,
			       biopax:BiochemicalReaction5055 ,
			       biopax:BiochemicalReaction5057 ,
			       biopax:BiochemicalReaction5058 ,
			       biopax:BiochemicalReaction5067 ,
			       biopax:BiochemicalReaction5083 ,
			       biopax:Catalysis2304 ,
			       biopax:Catalysis2334 ,
			       biopax:Catalysis2335 ,
			       biopax:Catalysis2337 ,
			       biopax:Catalysis2338 ,
			       biopax:Catalysis2347 ,
			       biopax:Catalysis2363 ;
	rdfs:label "PC is exchanged with PI by PITPNB"@em .

biopax:BiochemicalReaction5113
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004430 ;
	obo:BFO_0000050 biopax:Pathway1214 ;
	obo:directly_activates biopax:BiochemicalReaction5114 ,
			       biopax:Catalysis2388 ;
	rdfs:label "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane"@em .

biopax:BiochemicalReaction5114
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  obo:GO_0034596 ;
	obo:BFO_0000050 biopax:Pathway1214 ;
	obo:directly_activates biopax:BiochemicalReaction5053 ,
			       biopax:BiochemicalReaction5077 ,
			       biopax:BiochemicalReaction5078 ,
			       biopax:BiochemicalReaction5080 ,
			       biopax:BiochemicalReaction5113 ,
			       biopax:Catalysis2357 ,
			       biopax:Catalysis2358 ,
			       biopax:Catalysis2360 ,
			       biopax:Catalysis2387 ;
	rdfs:label "PI4P is dephosphorylated to PI by SACM1L at the ER membrane"@em .

biopax:BiochemicalReaction5115
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004430 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5118 ,
			       biopax:BiochemicalReaction5123 ,
			       biopax:BiochemicalReaction5126 ,
			       biopax:Catalysis2391 ,
			       biopax:Catalysis2396 ;
	rdfs:label "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane"@em .

biopax:BiochemicalReaction5116
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5117 ,
			       biopax:Catalysis2390 ;
	rdfs:label "PI4KB binds to ARF1/3:GTP at the Golgi membrane"@em .

biopax:BiochemicalReaction5117
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  obo:GO_0004430 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5118 ,
			       biopax:BiochemicalReaction5123 ,
			       biopax:BiochemicalReaction5126 ,
			       biopax:Catalysis2391 ,
			       biopax:Catalysis2396 ;
	rdfs:label "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane"@em .

biopax:BiochemicalReaction5118
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  obo:GO_0034596 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5115 ,
			       biopax:BiochemicalReaction5117 ,
			       biopax:BiochemicalReaction5119 ,
			       biopax:Catalysis2389 ,
			       biopax:Catalysis2390 ,
			       biopax:Catalysis2392 ;
	rdfs:label "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane"@em .

biopax:BiochemicalReaction5119
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016303 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5120 ,
			       biopax:BiochemicalReaction5121 ,
			       biopax:Catalysis2393 ,
			       biopax:Catalysis2394 ;
	rdfs:label "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane"@em .

biopax:BiochemicalReaction5120
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q9NTJ5
	  ] ,
	  obo:GO_0004438 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5115 ,
			       biopax:BiochemicalReaction5117 ,
			       biopax:BiochemicalReaction5119 ,
			       biopax:Catalysis2389 ,
			       biopax:Catalysis2390 ,
			       biopax:Catalysis2392 ;
	rdfs:label "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane"@em .

biopax:BiochemicalReaction5121
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  obo:GO_0000285 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5122 ,
			       biopax:Catalysis2395 ;
	rdfs:label "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane"@em .

biopax:BiochemicalReaction5122
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  obo:GO_0043813 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5120 ,
			       biopax:BiochemicalReaction5121 ,
			       biopax:Catalysis2393 ,
			       biopax:Catalysis2394 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane"@em .

biopax:BiochemicalReaction5123
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0035005 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5124 ,
			       biopax:Catalysis2397 ;
	rdfs:label "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane"@em .

biopax:BiochemicalReaction5124
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0000139
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q6XPS3
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q6XPS3
	  ] ,
	  obo:GO_0051800 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5118 ,
			       biopax:BiochemicalReaction5123 ,
			       biopax:BiochemicalReaction5126 ,
			       biopax:Catalysis2391 ,
			       biopax:Catalysis2396 ;
	rdfs:label "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane"@em .

biopax:BiochemicalReaction5125
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004439 ;
	obo:BFO_0000050 biopax:Pathway1215 ;
	obo:directly_activates biopax:BiochemicalReaction5118 ,
			       biopax:BiochemicalReaction5123 ,
			       biopax:BiochemicalReaction5126 ,
			       biopax:Catalysis2391 ,
			       biopax:Catalysis2396 ;
	rdfs:label "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane"@em .

biopax:BiochemicalReaction5126
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1216 ;
	obo:directly_activates biopax:BiochemicalReaction5127 ,
			       biopax:BiochemicalReaction5133 ,
			       biopax:BiochemicalReaction5144 ,
			       biopax:Catalysis2399 ,
			       biopax:Catalysis2405 ,
			       biopax:Catalysis2416 ;
	rdfs:label "PI4P transports from the Golgi membrane to the plasma membrane"@em .

biopax:BiochemicalReaction5127
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016308 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction4609 ,
			       biopax:BiochemicalReaction4610 ,
			       biopax:BiochemicalReaction5128 ,
			       biopax:BiochemicalReaction5129 ,
			       biopax:BiochemicalReaction979 ,
			       biopax:Catalysis2022 ,
			       biopax:Catalysis2023 ,
			       biopax:Catalysis2400 ,
			       biopax:Catalysis2401 ;
	rdfs:label "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane"@em .

biopax:BiochemicalReaction5128
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004439 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5127 ,
			       biopax:BiochemicalReaction5133 ,
			       biopax:BiochemicalReaction5144 ,
			       biopax:Catalysis2399 ,
			       biopax:Catalysis2405 ,
			       biopax:Catalysis2416 ;
	rdfs:label "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane"@em .

biopax:BiochemicalReaction5129
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0046934 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5130 ,
			       biopax:BiochemicalReaction5132 ,
			       biopax:Catalysis2402 ,
			       biopax:Catalysis2404 ;
	rdfs:label "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane"@em .

biopax:BiochemicalReaction5130
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016314 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction4609 ,
			       biopax:BiochemicalReaction4610 ,
			       biopax:BiochemicalReaction5128 ,
			       biopax:BiochemicalReaction5129 ,
			       biopax:Catalysis2022 ,
			       biopax:Catalysis2023 ,
			       biopax:Catalysis2400 ,
			       biopax:Catalysis2401 ;
	rdfs:label "PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane"@em .

biopax:BiochemicalReaction5131
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052812 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5130 ,
			       biopax:BiochemicalReaction5132 ,
			       biopax:Catalysis2402 ,
			       biopax:Catalysis2404 ;
	rdfs:label "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane"@em .

biopax:BiochemicalReaction5132
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0034485 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5131 ,
			       biopax:BiochemicalReaction5134 ,
			       biopax:BiochemicalReaction5136 ,
			       biopax:BiochemicalReaction5145 ,
			       biopax:Catalysis2403 ,
			       biopax:Catalysis2406 ,
			       biopax:Catalysis2408 ;
	rdfs:label "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane"@em .

biopax:BiochemicalReaction5133
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0035005 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5131 ,
			       biopax:BiochemicalReaction5134 ,
			       biopax:BiochemicalReaction5136 ,
			       biopax:BiochemicalReaction5145 ,
			       biopax:Catalysis2403 ,
			       biopax:Catalysis2406 ,
			       biopax:Catalysis2408 ;
	rdfs:label "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane"@em .

biopax:BiochemicalReaction5134
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0051800 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5127 ,
			       biopax:BiochemicalReaction5133 ,
			       biopax:BiochemicalReaction5144 ,
			       biopax:Catalysis2399 ,
			       biopax:Catalysis2405 ,
			       biopax:Catalysis2416 ;
	rdfs:label "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane"@em .

biopax:BiochemicalReaction5135
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052811 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5131 ,
			       biopax:BiochemicalReaction5134 ,
			       biopax:BiochemicalReaction5136 ,
			       biopax:BiochemicalReaction5145 ,
			       biopax:Catalysis2403 ,
			       biopax:Catalysis2406 ,
			       biopax:Catalysis2408 ;
	rdfs:label "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane"@em .

biopax:BiochemicalReaction5136
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016316 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5135 ,
			       biopax:BiochemicalReaction5137 ,
			       biopax:BiochemicalReaction5139 ,
			       biopax:Catalysis2407 ,
			       biopax:Catalysis2409 ,
			       biopax:Catalysis2411 ;
	rdfs:label "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane"@em .

biopax:BiochemicalReaction5137
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004438 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5082 ,
			       biopax:BiochemicalReaction5138 ,
			       biopax:BiochemicalReaction5143 ,
			       biopax:Catalysis2362 ,
			       biopax:Catalysis2410 ,
			       biopax:Catalysis2415 ;
	rdfs:label "PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane"@em .

biopax:BiochemicalReaction5138
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052810 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5142 ,
			       biopax:Catalysis2414 ;
	rdfs:label "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane"@em .

biopax:BiochemicalReaction5139
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0000285 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5140 ,
			       biopax:BiochemicalReaction5141 ,
			       biopax:Catalysis2412 ,
			       biopax:Catalysis2413 ;
	rdfs:label "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane"@em .

biopax:BiochemicalReaction5140
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0043813 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5135 ,
			       biopax:BiochemicalReaction5137 ,
			       biopax:BiochemicalReaction5139 ,
			       biopax:Catalysis2407 ,
			       biopax:Catalysis2409 ,
			       biopax:Catalysis2411 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane"@em .

biopax:BiochemicalReaction5141
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052629 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5142 ,
			       biopax:Catalysis2414 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane"@em .

biopax:BiochemicalReaction5142
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016309 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction4609 ,
			       biopax:BiochemicalReaction4610 ,
			       biopax:BiochemicalReaction5128 ,
			       biopax:BiochemicalReaction5129 ,
			       biopax:Catalysis2022 ,
			       biopax:Catalysis2023 ,
			       biopax:Catalysis2400 ,
			       biopax:Catalysis2401 ;
	rdfs:label "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane"@em .

biopax:BiochemicalReaction5143
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004430 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5127 ,
			       biopax:BiochemicalReaction5133 ,
			       biopax:BiochemicalReaction5144 ,
			       biopax:Catalysis2399 ,
			       biopax:Catalysis2405 ,
			       biopax:Catalysis2416 ;
	rdfs:label "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane"@em .

biopax:BiochemicalReaction5144
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0034596 ;
	obo:BFO_0000050 biopax:Pathway1217 ;
	obo:directly_activates biopax:BiochemicalReaction5082 ,
			       biopax:BiochemicalReaction5138 ,
			       biopax:BiochemicalReaction5143 ,
			       biopax:Catalysis2362 ,
			       biopax:Catalysis2410 ,
			       biopax:Catalysis2415 ;
	rdfs:label "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane"@em .

biopax:BiochemicalReaction5145
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1218 ;
	obo:directly_activates biopax:BiochemicalReaction5146 ,
			       biopax:Catalysis2417 ;
	rdfs:label "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane"@em .

biopax:BiochemicalReaction5146
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016316 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5147 ,
			       biopax:BiochemicalReaction5151 ,
			       biopax:Catalysis2418 ,
			       biopax:Catalysis2422 ;
	rdfs:label "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane"@em .

biopax:BiochemicalReaction5147
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031901
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031901
	  ] ,
	  obo:GO_0000285 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5148 ,
			       biopax:BiochemicalReaction5149 ,
			       biopax:BiochemicalReaction5154 ,
			       biopax:Catalysis2419 ,
			       biopax:Catalysis2420 ;
	rdfs:label "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane"@em .

biopax:BiochemicalReaction5148
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031901
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031901
	  ] ,
	  obo:GO_0043813 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5147 ,
			       biopax:BiochemicalReaction5151 ,
			       biopax:Catalysis2418 ,
			       biopax:Catalysis2422 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane"@em .

biopax:BiochemicalReaction5149
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052629 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane"@em .

biopax:BiochemicalReaction5150
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016303 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5147 ,
			       biopax:BiochemicalReaction5151 ,
			       biopax:Catalysis2418 ,
			       biopax:Catalysis2422 ;
	rdfs:label "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane"@em .

biopax:BiochemicalReaction5151
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004438 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5150 ,
			       biopax:BiochemicalReaction5152 ,
			       biopax:Catalysis2421 ,
			       biopax:Catalysis2423 ;
	rdfs:label "PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane"@em .

biopax:BiochemicalReaction5152
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004430 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5153 ,
			       biopax:Catalysis2424 ;
	rdfs:label "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane"@em .

biopax:BiochemicalReaction5153
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0035005 ;
	obo:BFO_0000050 biopax:Pathway1219 ;
	obo:directly_activates biopax:BiochemicalReaction5146 ,
			       biopax:Catalysis2417 ;
	rdfs:label "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane"@em .

biopax:BiochemicalReaction5154
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1220 ;
	obo:directly_activates biopax:BiochemicalReaction5122 ,
			       biopax:BiochemicalReaction5155 ,
			       biopax:Catalysis2395 ;
	rdfs:label "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane"@em .

biopax:BiochemicalReaction5155
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1221 ;
	obo:directly_activates biopax:BiochemicalReaction5157 ,
			       biopax:BiochemicalReaction5158 ,
			       biopax:BiochemicalReaction5162 ,
			       biopax:Catalysis2426 ,
			       biopax:Catalysis2427 ;
	rdfs:label "Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome"@em .

biopax:BiochemicalReaction5156
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  obo:GO_0000285 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	obo:directly_activates biopax:BiochemicalReaction5157 ,
			       biopax:BiochemicalReaction5158 ,
			       biopax:BiochemicalReaction5162 ,
			       biopax:Catalysis2426 ,
			       biopax:Catalysis2427 ;
	rdfs:label "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane"@em .

biopax:BiochemicalReaction5157
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  obo:GO_0043813 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	obo:directly_activates biopax:BiochemicalReaction5156 ,
			       biopax:BiochemicalReaction5161 ,
			       biopax:Catalysis2425 ,
			       biopax:Catalysis2430 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane"@em .

biopax:BiochemicalReaction5158
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0052629 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	rdfs:label "PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane"@em .

biopax:BiochemicalReaction5159
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0031902
	  ] ,
	  obo:GO_0052810 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	rdfs:label "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane"@em .

biopax:BiochemicalReaction5160
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016303 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	obo:directly_activates biopax:BiochemicalReaction5156 ,
			       biopax:BiochemicalReaction5161 ,
			       biopax:Catalysis2425 ,
			       biopax:Catalysis2430 ;
	rdfs:label "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane"@em .

biopax:BiochemicalReaction5161
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004438 ;
	obo:BFO_0000050 biopax:Pathway1222 ;
	obo:directly_activates biopax:BiochemicalReaction5159 ,
			       biopax:BiochemicalReaction5160 ,
			       biopax:Catalysis2428 ,
			       biopax:Catalysis2429 ;
	rdfs:label "PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane"@em .

biopax:BiochemicalReaction5162
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1223 ;
	obo:directly_activates biopax:BiochemicalReaction5122 ,
			       biopax:Catalysis2395 ;
	rdfs:label "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane"@em .

biopax:Pathway1201
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PI and PC transport between ER and Golgi membranes"@em .

biopax:Pathway1213
	a obo:GO_0008150 ;
	rdfs:label "PI Metabolism"@em .

biopax:Pathway1214
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "Synthesis of PIPs at the ER membrane"@em .

biopax:Pathway1215
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "Synthesis of PIPs at the Golgi membrane"@em .

biopax:Pathway1216
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PIPs transport between Golgi and plasma membranes"@em .

biopax:Pathway1217
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "Synthesis of PIPs at the plasma membrane"@em .

biopax:Pathway1218
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PIPs transport between plasma and early endosome membranes"@em .

biopax:Pathway1219
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "Synthesis of PIPs at the early endosome membrane"@em .

biopax:Pathway1220
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PIPs transport between early endosome and Golgi membranes"@em .

biopax:Pathway1221
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PIPs transport between early and late endosome membranes"@em .

biopax:Pathway1222
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "Synthesis of PIPs at the late endosome membrane"@em .

biopax:Pathway1223
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1213 ;
	rdfs:label "PIPs transport between late endosome and Golgi membranes"@em .