@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (30)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction679
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "PIP3 recruits PDPK1 to the membrane"@em .

biopax:BiochemicalReaction680
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "PIP3 recruits AKT to the membrane"@em .

biopax:BiochemicalReaction681
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	obo:directly_activates biopax:BiochemicalReaction684 ,
			       biopax:BiochemicalReaction735 ,
			       biopax:BiochemicalReaction736 ,
			       biopax:BiochemicalReaction737 ,
			       biopax:BiochemicalReaction738 ,
			       biopax:BiochemicalReaction739 ,
			       biopax:BiochemicalReaction740 ,
			       biopax:BiochemicalReaction741 ,
			       biopax:BiochemicalReaction742 ,
			       biopax:Catalysis252 ,
			       biopax:Catalysis282 ,
			       biopax:Catalysis283 ,
			       biopax:Catalysis284 ,
			       biopax:Catalysis285 ,
			       biopax:Catalysis286 ,
			       biopax:Catalysis287 ,
			       biopax:Catalysis288 ,
			       biopax:Catalysis289 ;
	rdfs:label "TORC2 (mTOR) phosphorylates AKT at S473"@em .

biopax:BiochemicalReaction682
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "AKT binds PDPK1"@em .

biopax:BiochemicalReaction683
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	obo:directly_activates biopax:BiochemicalReaction735 ,
			       biopax:BiochemicalReaction736 ,
			       biopax:BiochemicalReaction737 ,
			       biopax:BiochemicalReaction738 ,
			       biopax:BiochemicalReaction739 ,
			       biopax:BiochemicalReaction740 ,
			       biopax:BiochemicalReaction741 ,
			       biopax:BiochemicalReaction742 ,
			       biopax:Catalysis282 ,
			       biopax:Catalysis283 ,
			       biopax:Catalysis284 ,
			       biopax:Catalysis285 ,
			       biopax:Catalysis286 ,
			       biopax:Catalysis287 ,
			       biopax:Catalysis288 ,
			       biopax:Catalysis289 ;
	rdfs:label "PDPK1 phosphorylates AKT at T308"@em .

biopax:BiochemicalReaction734
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0046934 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "PI3K phosphorylates PIP2 to PIP3"@em .

biopax:BiochemicalReaction735
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	obo:directly_activates biopax:BiochemicalReaction6004 ;
	rdfs:label "AKT phosphorylates BAD"@em .

biopax:BiochemicalReaction736
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates GSK3"@em .

biopax:BiochemicalReaction737
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates caspase-9"@em .

biopax:BiochemicalReaction738
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates MDM2"@em .

biopax:BiochemicalReaction739
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates IKKalpha"@em .

biopax:BiochemicalReaction740
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates p21Cip1 and p27Kip1"@em .

biopax:BiochemicalReaction741
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates TSC2, inhibiting it"@em .

biopax:BiochemicalReaction742
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway228 ;
	rdfs:label "AKT phosphorylates AKT1S1 (PRAS40)"@em .

biopax:BiochemicalReaction743
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	obo:directly_activates biopax:BiochemicalReaction744 ,
			       biopax:BiochemicalReaction745 ,
			       biopax:BiochemicalReaction746 ,
			       biopax:BiochemicalReaction747 ,
			       biopax:Catalysis290 ,
			       biopax:Catalysis291 ,
			       biopax:Catalysis292 ,
			       biopax:Catalysis293 ;
	rdfs:label "AKT translocates to the nucleus"@em .

biopax:BiochemicalReaction744
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway229 ;
	rdfs:label "AKT phosphorylates CREB1"@em .

biopax:BiochemicalReaction745
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway229 ;
	rdfs:label "AKT can phosphorylate forkhead box transcription factors"@em .

biopax:BiochemicalReaction746
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway229 ;
	rdfs:label "AKT can phosphorylate RSK"@em .

biopax:BiochemicalReaction747
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway229 ;
	rdfs:label "AKT can phosphorylate NR4A1 (NUR77)"@em .

biopax:BiochemicalReaction748
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0016314 ;
	obo:BFO_0000050 biopax:Pathway230 ;
	obo:directly_activates biopax:BiochemicalReaction3944 ,
			       biopax:Catalysis1796 ;
	rdfs:label "PTEN dephosphorylates PIP3"@em .

biopax:BiochemicalReaction749
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway230 ;
	rdfs:label "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation"@em .

biopax:BiochemicalReaction750
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004722 ;
	obo:BFO_0000050 biopax:Pathway230 ;
	rdfs:label "PHLPP dephosphorylates S473 in AKT"@em .

biopax:BiochemicalReaction751
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	obo:directly_activates biopax:BiochemicalReaction3238 ;
	rdfs:label "PDPK1 binds PIP2"@em .

biopax:BiochemicalReaction752
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "MIR26A microRNAs bind PTEN mRNA"@em .

biopax:BiochemicalReaction753
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "PTEN mRNA translation negatively regulated by microRNAs"@em .

biopax:Pathway227
	a obo:GO_0008150 ;
	rdfs:label "PIP3 activates AKT signaling"@em .

biopax:Pathway228
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "AKT phosphorylates targets in the cytosol"@em .

biopax:Pathway229
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "AKT phosphorylates targets in the nucleus"@em .

biopax:Pathway230
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway227 ;
	rdfs:label "Negative regulation of the PI3K/AKT network"@em .