COMT
label: UniProt:P21964 COMT

DAT1
label: SLC6A3
label: UniProt:Q01959 SLC6A3

Reuptake of dopamine from the synaptic celft into neurons
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: DAT1
type: Restriction
  on property: enabled by
  some values from: DAT1
type: GO_0008504
BFO_0000050: Clearance of dopamine
directly activates: Enzymatic degradation of dopamine by COMT
directly activates: Enzymatic degradation of Dopamine by monoamine oxidase
label: Reuptake of dopamine from the synaptic cleft into neurons

Reuptake of serotonin from the synapse
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008504
BFO_0000050: Clearance of seratonin
directly activates: Metabolism of seratonin

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003990
BFO_0000050: Neurotransmitter Clearance In The Synaptic Cleft
directly activates: BiochemicalReaction1713
directly activates: Catalysis694
label: Acetylcholine clearance from synaptic cleft

Noradrenaline clearance from the synaptic cleft
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005326
BFO_0000050: Neurotransmitter Clearance In The Synaptic Cleft

methylation of Dopamine to form 3-Methoxytyramine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008168
BFO_0000050: Enzymatic degradation of dopamine by COMT

Oxidation of 3-Methoxytyramine to homovanillic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Enzymatic degradation of dopamine by COMT

oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Enzymatic degradation of Dopamine by monoamine oxidase
directly activates: Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
directly activates: Catalysis1668

Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: enabled by
  some values from: COMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008168
BFO_0000050: Enzymatic degradation of Dopamine by monoamine oxidase

Oxidative deamination of 5-Hydroxytryptamine by MAOA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0008131
BFO_0000050: Metabolism of seratonin

5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004029
BFO_0000050: Metabolism of seratonin

Neurotransmitter Clearance In The Synaptic Cleft
type: GO_0008150

Clearance of dopamine
type: GO_0008150
BFO_0000050: Neurotransmitter Clearance In The Synaptic Cleft
label: Dopamine clearance from the synaptic cleft

Enzymatic degradation of dopamine by COMT
type: GO_0008150
BFO_0000050: Clearance of dopamine

Enzymatic degradation of Dopamine by monoamine oxidase
type: GO_0008150
BFO_0000050: Clearance of dopamine

Clearance of seratonin
type: GO_0008150
BFO_0000050: Neurotransmitter Clearance In The Synaptic Cleft
label: Clearance of serotonin
label: Serotonin clearance from the synaptic cleft

Metabolism of seratonin
type: GO_0008150
BFO_0000050: Clearance of seratonin
label: Metabolism of serotonin