@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (13)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction1862
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway436 ;
	obo:directly_activates biopax:BiochemicalReaction1863 ;
	rdfs:label "Mad1 binds kinetochore"@em .

biopax:BiochemicalReaction1863
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway436 ;
	obo:directly_activates biopax:BiochemicalReaction1864 ;
	rdfs:label "MAD2 associates with the Mad1 kinetochore complex"@em .

biopax:BiochemicalReaction1864
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway436 ;
	obo:directly_activates biopax:BiochemicalReaction1865 ;
	rdfs:label "MAD2 converted  to an inhibitory state via interaction with Mad1"@em .

biopax:BiochemicalReaction1865
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway436 ;
	obo:directly_activates biopax:BiochemicalReaction1866 ,
			       biopax:BiochemicalReaction1867 ,
			       biopax:Pathway438 ;
	rdfs:label "Release of activated MAD2 from kinetochores"@em .

biopax:BiochemicalReaction1866
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway437 ;
	rdfs:label "Inactivation of APC/C via CDC20 sequestration"@em .

biopax:BiochemicalReaction1867
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway438 ;
	obo:directly_activates biopax:BiochemicalReaction1868 ;
	rdfs:label "Formation of the MCC complex"@em .

biopax:BiochemicalReaction1868
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway438 ;
	obo:directly_activates biopax:BiochemicalReaction2028 ,
			       biopax:BiochemicalReaction2520 ,
			       biopax:BiochemicalReaction3794 ;
	rdfs:label "Binding of the MCC complex to the APC/C complex"@em .

biopax:Pathway434
	a obo:GO_0008150 ;
	rdfs:label "Mitotic Spindle Checkpoint"@em .

biopax:Pathway435
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway434 ;
	rdfs:label "Amplification of signal from the kinetochores"@em .

biopax:Pathway436
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway435 ;
	rdfs:label "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal"@em .

biopax:Pathway437
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway434 ;
	rdfs:label "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"@em .

biopax:Pathway438
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway437 ;
	rdfs:label "Inactivation of APC/C via direct inhibition of the APC/C complex"@em .