@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (18)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction2068
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	obo:directly_activates biopax:BiochemicalReaction2069 ;
	rdfs:label "Formation of Axial/Lateral Elements of Synaptonemal Complex"@em .

biopax:BiochemicalReaction2069
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	obo:directly_activates biopax:BiochemicalReaction2070 ,
			       biopax:BiochemicalReaction2071 ;
	rdfs:label "Formation of the telomere bouquet"@em ,
		   "Telomere clustering at the nuclear membrane"@em .

biopax:BiochemicalReaction2070
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	rdfs:label "Formation of Central Elements of the Synaptonemal Complex"@em ,
		   "Synapsis"@em .

biopax:BiochemicalReaction2071
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	obo:directly_activates biopax:BiochemicalReaction2072 ;
	rdfs:label "Recruitment of BRCA1 to Unsynapsed Regions"@em .

biopax:BiochemicalReaction2072
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	obo:directly_activates biopax:BiochemicalReaction2073 ,
			       biopax:Catalysis926 ;
	rdfs:label "Recruitment of ATR Kinase to Unsynapsed Regions"@em .

biopax:BiochemicalReaction2073
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004674 ;
	obo:BFO_0000050 biopax:Pathway516 ;
	rdfs:label "ATR Phosphorylates Histone H2A.X at Unsynapsed Regions"@em .

biopax:BiochemicalReaction3782
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3783 ,
			       biopax:Catalysis1722 ;
	rdfs:label "PRDM9 Binds Recombination Hotspot Motifs in DNA"@em .

biopax:BiochemicalReaction3783
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0042800 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3784 ,
			       biopax:Catalysis1723 ;
	rdfs:label "Trimethylation of Histone H3 by PRDM9"@em .

biopax:BiochemicalReaction3784
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016888 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction2070 ,
			       biopax:BiochemicalReaction2071 ,
			       biopax:BiochemicalReaction3785 ,
			       biopax:Catalysis1724 ,
			       biopax:Catalysis1725 ;
	rdfs:label "Formation of Double-strand Break in DNA by SPO11"@em .

biopax:BiochemicalReaction3785
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004520 ,
	  obo:GO_0008296 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3786 ,
			       biopax:Control302 ,
			       biopax:Control303 ;
	rdfs:label "Removal of SPO11 and Resection of 5' Ends of DNA"@em .

biopax:BiochemicalReaction3786
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3787 ,
			       biopax:Catalysis1726 ,
			       biopax:Control304 ;
	rdfs:label "Formation of Early Recombination Nodule"@em ,
		   "Formation of Meiotic Single-stranded DNA Invasion Complex"@em .

biopax:BiochemicalReaction3787
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0000150 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3788 ;
	rdfs:label "Formation of Meiotic Heteroduplex"@em ,
		   "Meiotic Strand Invasion"@em .

biopax:BiochemicalReaction3788
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	obo:directly_activates biopax:BiochemicalReaction3789 ;
	rdfs:label "Formation of Meiotic Holliday Junction"@em ,
		   "Formation of Meiotic Recombination Intermediate"@em .

biopax:BiochemicalReaction3789
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway951 ;
	rdfs:label "Resolution of Meiotic Holliday Junction"@em .

biopax:Pathway516
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway950 ;
	rdfs:label "Meiotic Synapsis"@em .

biopax:Pathway950
	a obo:GO_0008150 ;
	rdfs:label "Meiosis"@em .

biopax:Pathway951
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway950 ;
	rdfs:label "Meiotic Recombination"@em .