@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (35)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P18858
	rdfs:label "LIG1"@em ,
		   "UniProt:P18858 LIG1"@em .

obo:UniProtKB_P39748
	rdfs:label "FEN1"@em ,
		   "RAD2"@em ,
		   "UniProt:P39748 FEN1"@em .

biopax:BiochemicalReaction2045
	a obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2046 ;
	rdfs:label "Biogenesis And Assembly Of The Telomerase RNP"@em ,
		   "TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP"@em .

biopax:BiochemicalReaction2046
	a obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2047 ;
	rdfs:label "Recruitment of Telomerase RNP to the Telomeric Chromosome End"@em .

biopax:BiochemicalReaction2047
	a obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2048 ,
			       biopax:Catalysis919 ;
	rdfs:label "Alignment Of The RNA Template On The Telomeric Chromosome End"@em .

biopax:BiochemicalReaction2048
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0003720 ,
	  obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2049 ;
	rdfs:label "Elongation Of The Telomeric Chromosome End"@em .

biopax:BiochemicalReaction2049
	a obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2050 ,
			       biopax:Catalysis920 ;
	rdfs:label "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"@em .

biopax:BiochemicalReaction2050
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0003720 ,
	  obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	obo:directly_activates biopax:BiochemicalReaction2051 ,
			       biopax:Pathway511 ;
	rdfs:label "Elongation of Extended Telomeric Chromosome End"@em .

biopax:BiochemicalReaction2051
	a obo:GO_0007004 ;
	obo:BFO_0000050 biopax:Pathway509 ;
	rdfs:label "Disassociation of Telomerase RNP and the Chromosome End"@em .

biopax:BiochemicalReaction2052
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0000722 ,
	  obo:GO_0003899 ;
	obo:BFO_0000050 biopax:Pathway511 ;
	obo:directly_activates biopax:BiochemicalReaction2053 ,
			       biopax:Catalysis922 ;
	rdfs:label "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"@em .

biopax:BiochemicalReaction2053
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0000722 ,
	  obo:GO_0003887 ;
	obo:BFO_0000050 biopax:Pathway511 ;
	obo:directly_activates biopax:BiochemicalReaction2054 ;
	rdfs:label "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"@em .

biopax:BiochemicalReaction2054
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway512 ;
	obo:directly_activates biopax:BiochemicalReaction2055 ;
	rdfs:label "RFC binding displaces Pol Alpha on the C-strand of the telomere"@em .

biopax:BiochemicalReaction2055
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway512 ;
	obo:directly_activates biopax:BiochemicalReaction2056 ;
	rdfs:label "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"@em .

biopax:BiochemicalReaction2056
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway512 ;
	obo:directly_activates biopax:BiochemicalReaction2057 ;
	rdfs:label "RFC dissociates after sliding clamp formation on the C-strand of the telomere"@em .

biopax:BiochemicalReaction2057
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway512 ;
	obo:directly_activates biopax:BiochemicalReaction2058 ,
			       biopax:Catalysis923 ;
	rdfs:label "Formation of Processive Complex on the C-strand of the telomere"@em .

biopax:BiochemicalReaction2058
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0000722 ,
	  obo:GO_0003887 ;
	obo:BFO_0000050 biopax:Pathway513 ;
	obo:directly_activates biopax:BiochemicalReaction2059 ;
	rdfs:label "Formation of C-strand Okazaki fragments"@em .

biopax:BiochemicalReaction2059
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway513 ;
	obo:directly_activates biopax:BiochemicalReaction2060 ,
			       biopax:Pathway514 ;
	rdfs:label "Formation of the Flap Intermediate on the C-strand"@em .

biopax:BiochemicalReaction2060
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway514 ;
	obo:directly_activates biopax:BiochemicalReaction2061 ;
	rdfs:label "RPA binds to the Flap on the C-strand"@em .

biopax:BiochemicalReaction2061
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway514 ;
	obo:directly_activates biopax:BiochemicalReaction2062 ;
	rdfs:label "Recruitment of Dna2 endonuclease to the C strand"@em .

biopax:BiochemicalReaction2062
	a obo:GO_0000722 ;
	obo:BFO_0000050 biopax:Pathway514 ;
	obo:directly_activates biopax:BiochemicalReaction2063 ,
			       biopax:Catalysis924 ;
	rdfs:label "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"@em .

biopax:BiochemicalReaction2063
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P39748
	  ] ,
	  obo:GO_0000722 ,
	  obo:GO_0017108 ;
	obo:BFO_0000050 biopax:Pathway514 ;
	rdfs:label "Removal of remaining Flap from the C-strand"@em .

biopax:BiochemicalReaction2064
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18858
	  ] ,
	  obo:GO_0000722 ,
	  obo:GO_0003909 ;
	obo:BFO_0000050 biopax:Pathway513 ;
	obo:directly_activates biopax:BiochemicalReaction2065 ;
	rdfs:label "Joining of adjacent Okazaki fragments of the C-strand"@em .

biopax:BiochemicalReaction2065
	a obo:GO_0000723 ;
	obo:BFO_0000050 biopax:Pathway510 ;
	obo:directly_activates biopax:BiochemicalReaction2066 ,
			       biopax:BiochemicalReaction2067 ;
	rdfs:label "Disassociation of Processive Complex and Completed Telomere End"@em .

biopax:BiochemicalReaction2066
	a obo:GO_0016233 ;
	obo:BFO_0000050 biopax:Pathway515 ;
	rdfs:label "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure"@em .

biopax:BiochemicalReaction2067
	a obo:GO_0016233 ;
	obo:BFO_0000050 biopax:Pathway515 ;
	rdfs:label "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure"@em .

biopax:Pathway507
	a obo:GO_0008150 ;
	rdfs:label "Maintenance of Telomeres"@em ,
		   "Telomere Maintenance"@em .

biopax:Pathway508
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway507 ;
	rdfs:label "Extension of Telomeres"@em .

biopax:Pathway509
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway508 ;
	rdfs:label "Telomere Extension By Telomerase"@em .

biopax:Pathway510
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway508 ;
	rdfs:label "Telomere C-strand (Lagging Strand) Synthesis"@em .

biopax:Pathway511
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway510 ;
	rdfs:label "Telomere C-strand synthesis initiation"@em .

biopax:Pathway512
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway510 ;
	rdfs:label "Polymerase switching on the C-strand of the telomere"@em .

biopax:Pathway513
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway510 ;
	rdfs:label "Processive synthesis on the C-strand of the telomere"@em .

biopax:Pathway514
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway513 ;
	rdfs:label "Removal of the Flap Intermediate from the C-strand"@em .

biopax:Pathway515
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway507 ;
	rdfs:label "Packaging Of Telomere Ends"@em .