@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (9)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction1440
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	obo:directly_activates biopax:BiochemicalReaction1441 ;
	rdfs:label "Phosphorylated SHC1 recruits GRB2:GAB2"@em .

biopax:BiochemicalReaction1441
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	obo:directly_activates biopax:BiochemicalReaction1442 ;
	rdfs:label "SHC1 mediates cytokine-induced phosphorylation of GAB2"@em .

biopax:BiochemicalReaction1442
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	rdfs:label "Gab2 binds the p85 subunit of Class 1A PI3 kinases"@em .

biopax:BiochemicalReaction1443
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	obo:directly_activates biopax:BiochemicalReaction1444 ,
			       biopax:BiochemicalReaction3817 ,
			       biopax:Catalysis1738 ,
			       biopax:Catalysis522 ;
	rdfs:label "Phosphorylated SHC recruits GRB2:SOS1"@em .

biopax:BiochemicalReaction1444
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0005088 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	obo:directly_activates biopax:BiochemicalReaction1275 ,
			       biopax:BiochemicalReaction1278 ;
	rdfs:label "SOS1 activates H-Ras"@em .

biopax:BiochemicalReaction1445
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	obo:directly_activates biopax:BiochemicalReaction1446 ;
	rdfs:label "Phosphorylated SHC1 recruits SHIP"@em .

biopax:BiochemicalReaction1446
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway355 ;
	rdfs:label "The SHC1:SHIP1 complex is stabilized by GRB2"@em .

biopax:Pathway355
	a obo:GO_0008150 ;
	rdfs:label "Interleukin receptor SHC signaling"@em .