@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (27)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction1003
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway287 ;
	obo:directly_activates biopax:BiochemicalReaction1007 ;
	rdfs:label "Ficolin-1 binds to molecular patterns on the target cell surface"@em .

biopax:BiochemicalReaction1004
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway287 ;
	obo:directly_activates biopax:BiochemicalReaction1007 ;
	rdfs:label "Ficolin-2 binds to molecular patterns on the target cell surface"@em .

biopax:BiochemicalReaction1005
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway287 ;
	obo:directly_activates biopax:BiochemicalReaction1007 ;
	rdfs:label "Ficolin-3 binds to molecular patterns on the target cell surface"@em .

biopax:BiochemicalReaction1006
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway286 ;
	obo:directly_activates biopax:BiochemicalReaction1007 ;
	rdfs:label "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa"@em .

biopax:BiochemicalReaction1007
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway286 ;
	obo:directly_activates biopax:BiochemicalReaction1010 ,
			       biopax:BiochemicalReaction1012 ,
			       biopax:Catalysis383 ,
			       biopax:Catalysis384 ;
	rdfs:label "Activation of MASPs"@em .

biopax:BiochemicalReaction1008
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway288 ;
	obo:directly_activates biopax:BiochemicalReaction1009 ,
			       biopax:Catalysis382 ;
	rdfs:label "Activation of C1R"@em .

biopax:BiochemicalReaction1009
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway288 ;
	obo:directly_activates biopax:BiochemicalReaction1010 ,
			       biopax:Catalysis383 ;
	rdfs:label "Activation of C1S"@em .

biopax:BiochemicalReaction1010
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	obo:directly_activates biopax:BiochemicalReaction1011 ,
			       biopax:BiochemicalReaction1059 ;
	rdfs:label "Conversion of C4 into C4a and C4b"@em .

biopax:BiochemicalReaction1011
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	obo:directly_activates biopax:BiochemicalReaction1013 ;
	rdfs:label "C4b binds to cell surface"@em .

biopax:BiochemicalReaction1012
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	obo:directly_activates biopax:BiochemicalReaction1013 ;
	rdfs:label "Conversion of C2 into C2a and C2b"@em .

biopax:BiochemicalReaction1013
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	obo:directly_activates biopax:BiochemicalReaction1028 ,
			       biopax:BiochemicalReaction1031 ,
			       biopax:BiochemicalReaction1043 ,
			       biopax:BiochemicalReaction1048 ,
			       biopax:Catalysis389 ;
	rdfs:label "Formation of Classical C3 convertase (C4b:C2a complex)"@em .

biopax:BiochemicalReaction1014
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1015 ;
	rdfs:label "Spontaneous hydrolysis of C3 thioester"@em .

biopax:BiochemicalReaction1015
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1016 ,
			       biopax:Catalysis385 ;
	rdfs:label "Factor B binds to C3(H2O)"@em .

biopax:BiochemicalReaction1016
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1017 ,
			       biopax:BiochemicalReaction1035 ,
			       biopax:BiochemicalReaction1043 ,
			       biopax:BiochemicalReaction1048 ,
			       biopax:Catalysis386 ,
			       biopax:Control77 ;
	rdfs:label "Factor D cleaves C3(H2O)-bound Factor B"@em .

biopax:BiochemicalReaction1017
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1018 ;
	rdfs:label "C3(H2O):Factor Bb cleaves C3 to C3b and C3a"@em .

biopax:BiochemicalReaction1018
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1019 ,
			       biopax:BiochemicalReaction1034 ,
			       biopax:Control76 ;
	rdfs:label "C3b binds to cell surface"@em .

biopax:BiochemicalReaction1019
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1020 ,
			       biopax:Catalysis387 ;
	rdfs:label "Factor B binds to surface-associated C3b"@em .

biopax:BiochemicalReaction1020
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1021 ,
			       biopax:BiochemicalReaction1035 ,
			       biopax:BiochemicalReaction1043 ,
			       biopax:BiochemicalReaction1048 ,
			       biopax:Control77 ;
	rdfs:label "Factor D cleaves C3b-bound Factor B"@em .

biopax:BiochemicalReaction1021
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1022 ,
			       biopax:BiochemicalReaction1028 ,
			       biopax:BiochemicalReaction1031 ,
			       biopax:Catalysis388 ,
			       biopax:Catalysis389 ;
	rdfs:label "Properdin stabilizes C3b:Bb bound to cell surfaces"@em .

biopax:BiochemicalReaction1022
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004252 ;
	obo:BFO_0000050 biopax:Pathway289 ;
	obo:directly_activates biopax:BiochemicalReaction1028 ,
			       biopax:BiochemicalReaction1030 ,
			       biopax:BiochemicalReaction1031 ,
			       biopax:Catalysis389 ,
			       biopax:Catalysis390 ;
	rdfs:label "Formation of alternative pathway C5 convertase"@em .

biopax:Pathway284
	a obo:GO_0008150 ;
	rdfs:label "Initial triggering of complement"@em .

biopax:Pathway285
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	rdfs:label "Creation of C4 and C2 activators"@em .

biopax:Pathway286
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway285 ;
	rdfs:label "Lectin pathway of complement activation"@em .

biopax:Pathway287
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway286 ;
	rdfs:label "Ficolins bind to repetitive carbohydrate structures on the target cell surface"@em .

biopax:Pathway288
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway285 ;
	rdfs:label "Classical antibody-mediated complement activation"@em .

biopax:Pathway289
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway284 ;
	rdfs:label "Alternative complement activation"@em .