ATP binds to P2X7
P2X7 forms oligomeric non-selective cation channels
P2X7 mediates loss of intracellular K+
P2X7 mediates membrane pores that include pannexin-1
SGT1 binds HSP90
SGT1:HSP90 binds inactive NLRP3
TXNIP binds reduced thioredoxin
ROS oxidize thioredoxin
TXNIP is released from oxidized thioredoxin
TXNIP binds NLRP3
NLRP3 activation by small molecules
NLRP3 activation by elicitor proteins
NLRP3 oligomerizes via NACHT domains
ASC is recruited via a PYD-PYD interaction
The CARD domain of ASC recruits Procaspase-1
PSTPIP1 binds Pyrin
Pyrin binds ASC
Bcl-2 and Bcl-XL bind NLRP1
NLRP1 senses MDP
MDP:NLRP1 binds ATP
NLRP1 oligomerizes
IPAF is activated
IPAF binds procaspase-1
AIM2 binds dsDNA
AIM2 oligomerizes
dsDNA:AIM2 clusters bind ASC
dsDNA:AIM2:ASC cluster binds procaspase-1
Inflammasomes
The NLRP3 inflammasome
The NLRP1 inflammasome
The IPAF inflammasome
The AIM2 inflammasome