ATP binds to P2X7
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: P2X7 forms oligomeric non-selective cation channels

P2X7 forms oligomeric non-selective cation channels
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: P2X7 mediates loss of intracellular K+
directly activates: P2X7 mediates membrane pores that include pannexin-1
directly activates: Catalysis400

P2X7 mediates loss of intracellular K+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004931
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 activation by small molecules
directly activates: NLRP3 activation by elicitor proteins

P2X7 mediates membrane pores that include pannexin-1
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 activation by small molecules
directly activates: NLRP3 activation by elicitor proteins

SGT1 binds HSP90
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: SGT1:HSP90 binds inactive NLRP3

SGT1:HSP90 binds inactive NLRP3
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 activation by small molecules
directly activates: NLRP3 activation by elicitor proteins

TXNIP binds reduced thioredoxin
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: TXNIP binds NLRP3

ROS oxidize thioredoxin
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: TXNIP is released from oxidized thioredoxin

TXNIP is released from oxidized thioredoxin
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: TXNIP binds reduced thioredoxin

TXNIP binds NLRP3
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 activation by small molecules
directly activates: NLRP3 activation by elicitor proteins

NLRP3 activation by small molecules
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 oligomerizes via NACHT domains

NLRP3 activation by elicitor proteins
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: NLRP3 oligomerizes via NACHT domains

NLRP3 oligomerizes via NACHT domains
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: ASC is recruited via a PYD-PYD interaction

ASC is recruited via a PYD-PYD interaction
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: The CARD domain of ASC recruits Procaspase-1
directly activates: Pyrin binds ASC

The CARD domain of ASC recruits Procaspase-1
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: BiochemicalReaction1397

PSTPIP1 binds Pyrin
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome
directly activates: Pyrin binds ASC

Pyrin binds ASC
type: GO_0003674
BFO_0000050: The NLRP3 inflammasome

Bcl-2 and Bcl-XL bind NLRP1
type: GO_0003674
BFO_0000050: The NLRP1 inflammasome

NLRP1 senses MDP
type: GO_0003674
BFO_0000050: The NLRP1 inflammasome
directly activates: MDP:NLRP1 binds ATP

MDP:NLRP1 binds ATP
type: GO_0003674
BFO_0000050: The NLRP1 inflammasome
directly activates: NLRP1 oligomerizes

NLRP1 oligomerizes
type: GO_0003674
BFO_0000050: The NLRP1 inflammasome

IPAF is activated
type: GO_0003674
BFO_0000050: The IPAF inflammasome
directly activates: IPAF binds procaspase-1

IPAF binds procaspase-1
type: GO_0003674
BFO_0000050: The IPAF inflammasome
directly activates: BiochemicalReaction1397

AIM2 binds dsDNA
type: GO_0003674
BFO_0000050: The AIM2 inflammasome
directly activates: AIM2 oligomerizes

AIM2 oligomerizes
type: GO_0003674
BFO_0000050: The AIM2 inflammasome
directly activates: dsDNA:AIM2 clusters bind ASC

dsDNA:AIM2 clusters bind ASC
type: GO_0003674
BFO_0000050: The AIM2 inflammasome
directly activates: dsDNA:AIM2:ASC cluster binds procaspase-1

dsDNA:AIM2:ASC cluster binds procaspase-1
type: GO_0003674
BFO_0000050: The AIM2 inflammasome
directly activates: BiochemicalReaction1397

Inflammasomes
type: GO_0008150

The NLRP3 inflammasome
type: GO_0008150
BFO_0000050: Inflammasomes

The NLRP1 inflammasome
type: GO_0008150
BFO_0000050: Inflammasomes

The IPAF inflammasome
type: GO_0008150
BFO_0000050: Inflammasomes

The AIM2 inflammasome
type: GO_0008150
BFO_0000050: Inflammasomes