@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (73)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P18754
	rdfs:label "CHC1"@em ,
		   "RCC1"@em ,
		   "UniProt:P18754 RCC1"@em .

biopax:BiochemicalReaction2648
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway630 ;
	rdfs:label "Association of Tat with P-TEFb(Cyclin T1:Cdk9)"@em .

biopax:BiochemicalReaction2670
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2671 ;
	rdfs:label "Rev molecules assemble onto the RRE RNA sequence through their ARM sequence"@em .

biopax:BiochemicalReaction2671
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2672 ,
			       biopax:BiochemicalReaction2674 ;
	rdfs:label "Multimerization of Rev"@em .

biopax:BiochemicalReaction2672
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	rdfs:label "Rev multimer-bound HIV mRNA associates with Crm1"@em .

biopax:BiochemicalReaction2673
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P18754
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0005087 ;
	obo:BFO_0000050 biopax:Pathway617 ,
			biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2674 ,
			       biopax:BiochemicalReaction2703 ;
	rdfs:label "Conversion of Ran-GDP to Ran-GTP"@em .

biopax:BiochemicalReaction2674
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2675 ;
	rdfs:label "Rev multimer-bound  HIV mRNA:CRM1 complex associates with Ran:GTP"@em .

biopax:BiochemicalReaction2675
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2676 ;
	rdfs:label "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC"@em .

biopax:BiochemicalReaction2676
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2677 ,
			       biopax:BiochemicalReaction2679 ,
			       biopax:Catalysis1152 ,
			       biopax:Control184 ,
			       biopax:Control185 ;
	rdfs:label "Translocation of nuclear RNA transport complex to cytoplasm"@em .

biopax:BiochemicalReaction2677
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2678 ;
	rdfs:label "Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex"@em .

biopax:BiochemicalReaction2678
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	obo:directly_activates biopax:BiochemicalReaction2679 ,
			       biopax:BiochemicalReaction2699 ,
			       biopax:Catalysis1152 ,
			       biopax:Control184 ,
			       biopax:Control185 ;
	rdfs:label "Release of the HIV mRNA and Crm1 from Rev in the cytoplasm"@em .

biopax:BiochemicalReaction2679
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0003924 ;
	obo:BFO_0000050 biopax:Pathway617 ;
	rdfs:label "Hydrolysis of Ran:GTP to Ran:GDP"@em .

biopax:BiochemicalReaction2695
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway624 ;
	obo:directly_activates biopax:BiochemicalReaction2696 ;
	rdfs:label "Translocation of Vpr to the mitochondria"@em .

biopax:BiochemicalReaction2696
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway624 ;
	obo:directly_activates biopax:BiochemicalReaction6024 ,
			       biopax:BiochemicalReaction6025 ;
	rdfs:label "Association of Vpr with ANT1"@em .

biopax:BiochemicalReaction2697
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway625 ;
	rdfs:label "Vpr binds nucleoporins"@em .

biopax:BiochemicalReaction2698
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway625 ;
	rdfs:label "Interaction of Vpr with importin alpha"@em .

biopax:BiochemicalReaction2699
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2700 ;
	rdfs:label "Association of multimerized Rev with beta-importin"@em .

biopax:BiochemicalReaction2700
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2701 ;
	rdfs:label "Rev associates with B23"@em .

biopax:BiochemicalReaction2701
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2702 ;
	rdfs:label "Rev:importin beta:B23 recruited to the nuclear pore"@em .

biopax:BiochemicalReaction2702
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2703 ,
			       biopax:BiochemicalReaction2704 ;
	rdfs:label "Translocation of Rev:importin-beta:B23 to the nucleus"@em .

biopax:BiochemicalReaction2703
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	rdfs:label "Association of Ran-GTP with importin-beta"@em .

biopax:BiochemicalReaction2704
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway627 ;
	obo:directly_activates biopax:BiochemicalReaction2670 ;
	rdfs:label "Disassembly of the Rev-importin beta-B23:Ran-GTP complex"@em .

biopax:BiochemicalReaction2705
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway628 ;
	rdfs:label "Association of APOBEC3G with Gag"@em .

biopax:BiochemicalReaction2706
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway628 ;
	obo:directly_activates biopax:BiochemicalReaction2707 ,
			       biopax:Catalysis1155 ;
	rdfs:label "Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand"@em .

biopax:BiochemicalReaction2707
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0008829 ;
	obo:BFO_0000050 biopax:Pathway628 ;
	rdfs:label "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand"@em .

biopax:BiochemicalReaction2708
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway629 ;
	obo:directly_activates biopax:BiochemicalReaction2709 ;
	rdfs:label "Association of Vif with APOBEC3G"@em .

biopax:BiochemicalReaction2709
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway629 ;
	obo:directly_activates biopax:BiochemicalReaction2710 ,
			       biopax:Catalysis1156 ;
	rdfs:label "Association of APOBEC3G:Vif with the Cul5-SCF complex"@em .

biopax:BiochemicalReaction2710
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway629 ;
	obo:directly_activates biopax:BiochemicalReaction2711 ,
			       biopax:Catalysis1157 ;
	rdfs:label "Multi-ubiquitination of APOBEC3G"@em .

biopax:BiochemicalReaction2711
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway629 ;
	rdfs:label "Proteosome-mediated degradation of APOBEC3G"@em .

biopax:BiochemicalReaction2712
	a obo:GO_0050690 ;
	obo:BFO_0000050 biopax:Pathway632 ;
	rdfs:label "Nef mediated activation of the T-cell receptor"@em .

biopax:BiochemicalReaction2713
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway632 ;
	rdfs:label "Nef Binds and activates the Src-family tyrosine kinase Hck"@em .

biopax:BiochemicalReaction2714
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway632 ;
	rdfs:label "Nef Binds and activates the Src-family tyrosine kinase Fyn"@em .

biopax:BiochemicalReaction2715
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway632 ;
	rdfs:label "Nef Binds and activates the Src-family tyrosine kinase Lck"@em .

biopax:BiochemicalReaction2716
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway632 ;
	rdfs:label "Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction"@em .

biopax:BiochemicalReaction2717
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway634 ;
	obo:directly_activates biopax:BiochemicalReaction2718 ;
	rdfs:label "Formation of Nef CD28 cytoplasmic tail complex"@em .

biopax:BiochemicalReaction2718
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway634 ;
	obo:directly_activates biopax:BiochemicalReaction2719 ;
	rdfs:label "Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex"@em .

biopax:BiochemicalReaction2719
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway634 ;
	rdfs:label "Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex"@em .

biopax:BiochemicalReaction2720
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway635 ;
	obo:directly_activates biopax:BiochemicalReaction2721 ;
	rdfs:label "Formation of MHC I:Nef Complex"@em .

biopax:BiochemicalReaction2721
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway635 ;
	obo:directly_activates biopax:BiochemicalReaction2722 ;
	rdfs:label "Formation of MHC I:Nef:AP-1:PACS-1 Complex"@em .

biopax:BiochemicalReaction2722
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway635 ;
	obo:directly_activates biopax:BiochemicalReaction2723 ;
	rdfs:label "Transport of MHC I:Nef:AP-1:PACS-1 Complex"@em .

biopax:BiochemicalReaction2723
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway635 ;
	rdfs:label "Degradation of MHC I Complex"@em .

biopax:BiochemicalReaction2724
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway636 ;
	obo:directly_activates biopax:BiochemicalReaction2725 ;
	rdfs:label "Nef mediated disruption of CD4:Lck Complex"@em .

biopax:BiochemicalReaction2725
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway636 ;
	obo:directly_activates biopax:BiochemicalReaction2726 ,
			       biopax:BiochemicalReaction2730 ;
	rdfs:label "Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex"@em .

biopax:BiochemicalReaction2726
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway636 ;
	obo:directly_activates biopax:BiochemicalReaction2728 ,
			       biopax:BiochemicalReaction2731 ;
	rdfs:label "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex"@em .

biopax:BiochemicalReaction2727
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway636 ;
	obo:directly_activates biopax:BiochemicalReaction2728 ;
	rdfs:label "Formation of a Nef:ARF1:CD4 complex"@em .

biopax:BiochemicalReaction2728
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway636 ;
	rdfs:label "Degradation of CD4"@em .

biopax:BiochemicalReaction2729
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway637 ;
	obo:directly_activates biopax:BiochemicalReaction2730 ;
	rdfs:label "Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex"@em .

biopax:BiochemicalReaction2730
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway637 ;
	obo:directly_activates biopax:BiochemicalReaction2731 ;
	rdfs:label "Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex"@em .

biopax:BiochemicalReaction2731
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway637 ;
	rdfs:label "Degradation of CD8"@em .

biopax:BiochemicalReaction2732
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway638 ;
	obo:directly_activates biopax:BiochemicalReaction2733 ;
	rdfs:label "Association of Vpu with CD4"@em .

biopax:BiochemicalReaction2733
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway638 ;
	obo:directly_activates biopax:BiochemicalReaction2734 ;
	rdfs:label "Vpu:CD4 associates with beta-TrCP"@em .

biopax:BiochemicalReaction2734
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway638 ;
	obo:directly_activates biopax:BiochemicalReaction2735 ,
			       biopax:Catalysis1158 ;
	rdfs:label "The Vpu:CD4:beta-TrCP complex recruits SKP1"@em .

biopax:BiochemicalReaction2735
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway638 ;
	obo:directly_activates biopax:BiochemicalReaction2736 ,
			       biopax:Catalysis1159 ;
	rdfs:label "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex"@em .

biopax:BiochemicalReaction2736
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway638 ;
	rdfs:label "Degradation of ubiquitinated CD4"@em .

biopax:Pathway617
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway626 ;
	rdfs:label "Rev-mediated nuclear export of HIV RNA"@em .

biopax:Pathway622
	a obo:GO_0008150 ;
	rdfs:label "Host Interactions of HIV factors"@em .

biopax:Pathway623
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "Interactions of Vpr with host cellular proteins"@em .

biopax:Pathway624
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway623 ;
	rdfs:label "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization"@em .

biopax:Pathway625
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway623 ;
	rdfs:label "Vpr-mediated nuclear import of PICs"@em .

biopax:Pathway626
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "Interactions of Rev with host cellular proteins"@em .

biopax:Pathway627
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway626 ;
	rdfs:label "Nuclear import of Rev protein"@em .

biopax:Pathway628
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "APOBEC3G mediated resistance to HIV-1 infection"@em .

biopax:Pathway629
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "Vif-mediated degradation of APOBEC3G"@em .

biopax:Pathway630
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "Interactions of Tat with host cellular proteins"@em .

biopax:Pathway631
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "The role of Nef in HIV-1 replication and disease pathogenesis"@em .

biopax:Pathway632
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway631 ;
	rdfs:label "Nef and signal transduction"@em .

biopax:Pathway633
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway631 ;
	rdfs:label "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters"@em .

biopax:Pathway634
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway633 ;
	rdfs:label "Nef mediated downregulation of CD28 cell surface expression"@em .

biopax:Pathway635
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway633 ;
	rdfs:label "Nef mediated downregulation of MHC class I complex cell surface expression"@em .

biopax:Pathway636
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway633 ;
	rdfs:label "Nef Mediated CD4 Down-regulation"@em .

biopax:Pathway637
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway633 ;
	rdfs:label "Nef Mediated CD8 Down-regulation"@em .

biopax:Pathway638
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway622 ;
	rdfs:label "Vpu mediated degradation of CD4"@em .