GLCE
label: KIAA0836
label: UniProt:O94923 GLCE

HFRC
label: SLC35D2
label: UGTREL8
label: UniProt:Q76EJ3 SLC35D2

HS2ST
label: HS2ST1
label: KIAA0448
label: UniProt:Q7LGA3 HS2ST1

SLC35D2 exchanges UDP-sugars for UMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: GO_0005338
BFO_0000050: HS-GAG biosynthesis
directly activates: BiochemicalReaction3069
directly activates: The addition of GlcNAc to the terminal glucuronate residue creates heparan
directly activates: Catalysis1303
directly activates: Catalysis1318

The addition of GlcNAc to the terminal glucuronate residue creates heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Glucuronate is added to the heparan chain
directly activates: Catalysis1319

Glucuronate is added to the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcNAc addition extends the heparan chain
directly activates: Catalysis1320

Another GlcNAc addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050508
BFO_0000050: HS-GAG biosynthesis
directly activates: Another GlcA addition extends the heparan chain
directly activates: Catalysis1321

Another GlcA addition extends the heparan chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050509
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 N-deacetylates GlcNAc residues in heparan
directly activates: Catalysis1322

NDST1-4 N-deacetylates GlcNAc residues in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050119
BFO_0000050: HS-GAG biosynthesis
directly activates: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
directly activates: Catalysis1323

NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0015016
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises GlcA to IdoA
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1324

GLCE epimerises GlcA to IdoA
type: Restriction
  on property: enabled by
  some values from: GLCE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS2ST1 sulfates IdoA at C2 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1325

HS2ST1 sulfates IdoA at C2 in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HS2ST
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004394
BFO_0000050: HS-GAG biosynthesis
directly activates: HS3STs sulfate GlcN at C3 in heparan sulfate
directly activates: HS3ST1 sulfates GlcN at C3 in heparan sulfate
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1326
directly activates: Catalysis1327

HS3STs sulfate GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

HS3ST1 sulfates GlcN at C3 in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005796
type: GO_0008467
BFO_0000050: HS-GAG biosynthesis
directly activates: GLCE epimerises more GlcA to IdoA as sulfate content rises
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1328

GLCE epimerises more GlcA to IdoA as sulfate content rises
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: GLCE
type: GO_0050379
BFO_0000050: HS-GAG biosynthesis
directly activates: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
directly activates: Some HSPGs are secreted to the plasma membrane
directly activates: Catalysis1329

HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0017095
BFO_0000050: HS-GAG biosynthesis
directly activates: Some HSPGs are secreted to the plasma membrane

Some HSPGs are secreted to the plasma membrane
type: GO_0003674
BFO_0000050: HS-GAG biosynthesis
directly activates: BiochemicalReaction3099
directly activates: BiochemicalReaction3101
directly activates: Catalysis1331

HS-GAG biosynthesis
type: GO_0008150