GLCE
KIAA0836
UniProt:O94923 GLCE
HFRC
SLC35D2
UGTREL8
UniProt:Q76EJ3 SLC35D2
HS2ST
HS2ST1
KIAA0448
UniProt:Q7LGA3 HS2ST1
SLC35D2 exchanges UDP-sugars for UMP
The addition of GlcNAc to the terminal glucuronate residue creates heparan
Glucuronate is added to the heparan chain
Another GlcNAc addition extends the heparan chain
Another GlcA addition extends the heparan chain
NDST1-4 N-deacetylates GlcNAc residues in heparan
NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
GLCE epimerises GlcA to IdoA
HS2ST1 sulfates IdoA at C2 in heparan sulfate
HS3STs sulfate GlcN at C3 in heparan sulfate
HS3ST1 sulfates GlcN at C3 in heparan sulfate
GLCE epimerises more GlcA to IdoA as sulfate content rises
HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
Some HSPGs are secreted to the plasma membrane
HS-GAG biosynthesis