@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (25)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P04180
	rdfs:label "LCAT"@em ,
		   "UniProt:P04180 LCAT"@em .

biopax:BiochemicalReaction1580
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0017127 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4702 ,
			       biopax:BiochemicalReaction4706 ,
			       biopax:Control384 ;
	rdfs:label "ABCG1-mediated transport of intracellular cholesterol to the cell surface"@em .

biopax:BiochemicalReaction4696
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  obo:GO_0004222 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4697 ;
	rdfs:label "Conversion of pro-apoA-I to apoA-I"@em .

biopax:BiochemicalReaction4697
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4698 ,
			       biopax:BiochemicalReaction4699 ,
			       biopax:Catalysis2083 ,
			       biopax:Catalysis2084 ;
	rdfs:label "ABCA1 tetramer binds apoA-I"@em .

biopax:BiochemicalReaction4698
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0017127 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4700 ,
			       biopax:BiochemicalReaction4701 ;
	rdfs:label "ABCA1-mediated transport of intracellular cholesterol to the cell surface"@em .

biopax:BiochemicalReaction4699
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0005548 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4700 ,
			       biopax:BiochemicalReaction4701 ;
	rdfs:label "ABCA1-mediated transport of intracellular phospholipid to the cell surface"@em .

biopax:BiochemicalReaction4700
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4702 ,
			       biopax:BiochemicalReaction4703 ;
	rdfs:label "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle"@em .

biopax:BiochemicalReaction4701
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle"@em .

biopax:BiochemicalReaction4702
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "Discoidal HDL binds membrane-associated free cholesterol"@em .

biopax:BiochemicalReaction4703
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4704 ;
	rdfs:label "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex"@em .

biopax:BiochemicalReaction4704
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL"@em .

biopax:BiochemicalReaction4705
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "Spherical HDL binds C and E apolipoproteins"@em .

biopax:BiochemicalReaction4706
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "Spherical HDL binds membrane-associated free cholesterol and phospholipids"@em .

biopax:BiochemicalReaction4707
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005576
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P04180
	  ] ,
	  obo:GO_0004607 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4708 ;
	rdfs:label "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)"@em .

biopax:BiochemicalReaction4708
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "2 2-lysophosphatidylcholine + serum albumin => albumin:2-lysophosphatidylcholine complex"@em ,
		   "Serum albumin binds 2-lysophosphatidylcholine"@em .

biopax:BiochemicalReaction4709
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4710 ;
	rdfs:label "LCAT + spherical HDL <=> LCAT:spherical HDL complex"@em .

biopax:BiochemicalReaction4710
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "LCAT:spherical HDL complex <=> LCAT + spherical HDL"@em .

biopax:BiochemicalReaction4711
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4716 ;
	rdfs:label "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol"@em ,
		   "CETP:triacylglycerol complex + spherical HDL <=> CETP:cholesterol ester complex + spherical HDL:triacylglycerol"@em .

biopax:BiochemicalReaction4712
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex"@em .

biopax:BiochemicalReaction4713
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4714 ;
	rdfs:label "spherical HDL and SR-BI receptor form a complex at the cell surface"@em .

biopax:BiochemicalReaction4714
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:BiochemicalReaction4701 ;
	rdfs:label "Disassembly of SR-BI-bound spherical HDL"@em .

biopax:BiochemicalReaction4715
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	obo:directly_activates biopax:Degradation18 ;
	rdfs:label "apoA-I binds to CUBN:AMN"@em .

biopax:Degradation18
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1153 ;
	rdfs:label "Endocytosis and degradation of apoA-I"@em .

biopax:Pathway1153
	a obo:GO_0008150 ;
	rdfs:label "HDL-mediated lipid transport"@em .