@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (31)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P78536
	rdfs:label "ADAM17"@em ,
		   "CSVP"@em ,
		   "TACE"@em ,
		   "UniProt:P78536 ADAM17"@em .

biopax:BiochemicalReaction1449
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1450 ;
	rdfs:label "Phosphorylated STAT5 forms dimers"@em .

biopax:BiochemicalReaction1450
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "STAT5 dimers translocate to the nucleus and bind to specific DNA sequences"@em .

biopax:BiochemicalReaction1511
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "Growth hormone forms dimers and oligomers"@em .

biopax:BiochemicalReaction1512
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1513 ,
			       biopax:Control111 ;
	rdfs:label "Growth hormone receptor binds JAK2"@em .

biopax:BiochemicalReaction1513
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1514 ;
	rdfs:label "Growth hormone receptor dimerizes"@em .

biopax:BiochemicalReaction1514
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1515 ,
			       biopax:BiochemicalReaction1522 ;
	rdfs:label "Growth hormone binds the growth hormone receptor"@em .

biopax:BiochemicalReaction1515
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1516 ,
			       biopax:Control112 ;
	rdfs:label "GH:GHR:JAK2 complex undergoes a conformational change"@em .

biopax:BiochemicalReaction1516
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1517 ,
			       biopax:BiochemicalReaction1518 ,
			       biopax:BiochemicalReaction1524 ,
			       biopax:BiochemicalReaction1542 ,
			       biopax:Catalysis535 ,
			       biopax:Catalysis536 ;
	rdfs:label "JAK2 phosphorylation"@em .

biopax:BiochemicalReaction1517
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004715 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "JAK2 phosphorylation of IRS-1/2"@em .

biopax:BiochemicalReaction1518
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004713 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1519 ,
			       biopax:BiochemicalReaction1526 ,
			       biopax:BiochemicalReaction1527 ,
			       biopax:BiochemicalReaction1528 ,
			       biopax:BiochemicalReaction1531 ;
	rdfs:label "JAK2 phosphorylation of GHR"@em .

biopax:BiochemicalReaction1519
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1520 ,
			       biopax:Catalysis537 ;
	rdfs:label "STAT5 association with GHR"@em .

biopax:BiochemicalReaction1520
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004713 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1521 ;
	rdfs:label "STAT5 tyrosine phosphorylation"@em .

biopax:BiochemicalReaction1521
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1449 ;
	rdfs:label "Phosphorylated STAT5 is released"@em .

biopax:BiochemicalReaction1522
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1523 ,
			       biopax:Catalysis538 ;
	rdfs:label "Growth hormone receptor binds Lyn"@em .

biopax:BiochemicalReaction1523
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004715 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "Lyn activates ERK"@em .

biopax:BiochemicalReaction1524
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1525 ,
			       biopax:Catalysis539 ;
	rdfs:label "JAK2 binds STAT1/3"@em .

biopax:BiochemicalReaction1525
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004715 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "JAK2 phosphorylates STAT1/STAT3"@em .

biopax:BiochemicalReaction1526
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "SOCS binding to GHR"@em .

biopax:BiochemicalReaction1527
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "SOCS binding to JAK2"@em .

biopax:BiochemicalReaction1528
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1529 ,
			       biopax:BiochemicalReaction1530 ,
			       biopax:Catalysis540 ,
			       biopax:Catalysis541 ;
	rdfs:label "PTP1B binds the GH receptor complex"@em .

biopax:BiochemicalReaction1529
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004725 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "PTP1B dephosphorylates GHR"@em .

biopax:BiochemicalReaction1530
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004725 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "PTP1B dephosphorylates JAK2"@em .

biopax:BiochemicalReaction1531
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	obo:directly_activates biopax:BiochemicalReaction1532 ,
			       biopax:Catalysis542 ;
	rdfs:label "SHP1 (PTPN6) binds JAK2 in the receptor complex"@em .

biopax:BiochemicalReaction1532
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004725 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "SHP1 (PTPN6) dephosphorylates JAK2"@em .

biopax:BiochemicalReaction1533
	a [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P78536
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004222 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "Metalloprotease cleavage of GHR"@em .

biopax:BiochemicalReaction1534
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "GHBP binds GH"@em .

biopax:BiochemicalReaction1535
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "GHBP binds GHR"@em .

biopax:BiochemicalReaction1536
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway360 ;
	rdfs:label "GHR internalization"@em .

biopax:Pathway360
	a obo:GO_0008150 ;
	rdfs:label "Growth hormone receptor signaling"@em .