@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (30)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P08034
	rdfs:label "CX32"@em ,
		   "GJB1"@em ,
		   "UniProt:P08034 GJB1"@em .

biopax:BiochemicalReaction3415
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway807 ;
	obo:directly_activates biopax:BiochemicalReaction3418 ;
	rdfs:label "Transport of connexins to the ER-Golgi intermediate compartment"@em .

biopax:BiochemicalReaction3416
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway807 ;
	obo:directly_activates biopax:BiochemicalReaction3419 ;
	rdfs:label "Transport of connexins to the Trans-Golgi Network (TGN)"@em .

biopax:BiochemicalReaction3417
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005789
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P08034
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P08034
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P08034
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P08034
	  ] ,
	  obo:GO_0005243 ;
	obo:BFO_0000050 biopax:Pathway808 ;
	rdfs:label "Connexin oligomerization in endoplasmic reticulum membrane"@em .

biopax:BiochemicalReaction3418
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway808 ;
	rdfs:label "Connexin oligomerization in  ER-Golgi-Intermediate Compartment"@em .

biopax:BiochemicalReaction3419
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway808 ;
	obo:directly_activates biopax:BiochemicalReaction3421 ;
	rdfs:label "Connexin oligomerization in Trans-Golgi Network (TGN)"@em .

biopax:BiochemicalReaction3420
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway809 ;
	rdfs:label "Microtubule-independent trafficking of connexons to the plasma membrane"@em .

biopax:BiochemicalReaction3421
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway810 ;
	obo:directly_activates biopax:BiochemicalReaction3422 ;
	rdfs:label "Budding of connexon-containing transport vesicles from the Golgi"@em .

biopax:BiochemicalReaction3422
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway810 ;
	obo:directly_activates biopax:BiochemicalReaction3423 ;
	rdfs:label "Association of Golgi  transport vesicles with microtubules"@em .

biopax:BiochemicalReaction3423
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3424 ;
	rdfs:label "Docking of connexons into junctional, double-membrane spanning channels"@em .

biopax:BiochemicalReaction3424
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3425 ;
	rdfs:label "Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels"@em .

biopax:BiochemicalReaction3425
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3426 ;
	rdfs:label "Formation of junctional channels"@em .

biopax:BiochemicalReaction3426
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	rdfs:label "Assembly of gap junction plaques"@em .

biopax:BiochemicalReaction3427
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway812 ;
	obo:directly_activates biopax:BiochemicalReaction3428 ;
	rdfs:label "Dab2 is recruited to the junctional plaques"@em .

biopax:BiochemicalReaction3428
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway812 ;
	obo:directly_activates biopax:BiochemicalReaction3429 ;
	rdfs:label "Dynamin is recruited to the gap junction plaque"@em .

biopax:BiochemicalReaction3429
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway811 ;
	obo:directly_activates biopax:Degradation9 ;
	rdfs:label "Internalization of gap junction plaques"@em .

biopax:Degradation9
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway811 ;
	rdfs:label "Lysosomal degradation of gap junction plaques"@em .

biopax:Pathway805
	a obo:GO_0008150 ;
	rdfs:label "Gap junction trafficking"@em .

biopax:Pathway806
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway805 ;
	rdfs:label "Gap junction assembly"@em .

biopax:Pathway807
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	rdfs:label "Transport of connexins along the secretory pathway"@em .

biopax:Pathway808
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	rdfs:label "Oligomerization of connexins into connexons"@em .

biopax:Pathway809
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	rdfs:label "Transport of connexons to the plasma membrane"@em .

biopax:Pathway810
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway809 ;
	rdfs:label "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane"@em .

biopax:Pathway811
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway805 ;
	rdfs:label "Gap junction degradation"@em .

biopax:Pathway812
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway811 ;
	rdfs:label "Formation of annular gap junctions"@em .

biopax:TemplateReaction43
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	rdfs:label "Connexin synthesis (generic)"@em .

biopax:TemplateReaction44
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3415 ;
	rdfs:label "Synthesis of Cx26"@em .

biopax:TemplateReaction45
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3415 ,
			       biopax:BiochemicalReaction3417 ,
			       biopax:Catalysis1456 ;
	rdfs:label "Synthesis of Cx32"@em .

biopax:TemplateReaction46
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway806 ;
	obo:directly_activates biopax:BiochemicalReaction3416 ;
	rdfs:label "Synthesis of Cx43"@em .