@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (10)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction2321
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1097 ;
	obo:directly_activates biopax:BiochemicalReaction2322 ;
	rdfs:label "PIP3 recruits PDK1 and AKT to the membrane"@em .

biopax:BiochemicalReaction3945
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1097 ;
	rdfs:label "PIP3 binds to RhoA and activates it"@em .

biopax:BiochemicalReaction4384
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1097 ;
	obo:directly_activates biopax:BiochemicalReaction4385 ,
			       biopax:Catalysis1894 ;
	rdfs:label "Gbeta:gamma recruits PI3K gamma"@em .

biopax:BiochemicalReaction4385
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0046934 ;
	obo:BFO_0000050 biopax:Pathway1097 ;
	obo:directly_activates biopax:BiochemicalReaction2321 ,
			       biopax:BiochemicalReaction3945 ,
			       biopax:BiochemicalReaction679 ,
			       biopax:BiochemicalReaction680 ,
			       biopax:Control158 ;
	rdfs:label "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3"@em .

biopax:BiochemicalReaction4386
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1098 ;
	obo:directly_activates biopax:BiochemicalReaction4387 ,
			       biopax:Catalysis1895 ;
	rdfs:label "Gbeta:gamma activation of PLC beta"@em .

biopax:BiochemicalReaction4387
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004629 ;
	obo:BFO_0000050 biopax:Pathway1098 ;
	obo:directly_activates biopax:BiochemicalReaction2349 ,
			       biopax:BiochemicalReaction2350 ,
			       biopax:BiochemicalReaction2351 ,
			       biopax:BiochemicalReaction2352 ,
			       biopax:BiochemicalReaction2353 ,
			       biopax:BiochemicalReaction2355 ,
			       biopax:BiochemicalReaction2356 ,
			       biopax:BiochemicalReaction715 ,
			       biopax:Catalysis1036 ,
			       biopax:Catalysis1038 ,
			       biopax:Control159 ;
	rdfs:label "PLC beta-mediated PIP2 hydrolysis"@em .

biopax:Pathway1096
	a obo:GO_0008150 ;
	rdfs:label "G-protein beta:gamma signalling"@em .

biopax:Pathway1097
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1096 ;
	rdfs:label "G beta:gamma signalling through PI3Kgamma"@em .

biopax:Pathway1098
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1096 ;
	rdfs:label "G beta:gamma signalling through PLC beta"@em .