CHEK1
CHK1
UniProt:O14757 CHEK1
UniProt:P30291 WEE1
WEE1
ATM
UniProt:Q13315 ATM
Recruitment and activation of Chk1
Phosphorylation and activation of CHK2 by ATM
Phosphorylation of Cdc25C at Ser216
Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins
Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm
Phosphorylation of Wee1 kinase by Chk1
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
G2/M DNA damage checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex