CHEK1
label: CHK1
label: UniProt:O14757 CHEK1

UniProt:P30291 WEE1
label: WEE1

ATM
label: UniProt:Q13315 ATM

Recruitment and activation of Chk1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
type: GO_0006260
BFO_0000050: G2/M DNA damage checkpoint
directly activates: BiochemicalReaction1846
directly activates: BiochemicalReaction1861
directly activates: Catalysis814
directly activates: Catalysis822

Phosphorylation and activation of CHK2 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: G2/M DNA damage checkpoint
directly activates: BiochemicalReaction1842
directly activates: Catalysis810

Phosphorylation of Cdc25C at Ser216
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins

Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins
type: GO_0003674
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm

Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm
type: GO_0003674
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Phosphorylation of Wee1 kinase by Chk1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: enabled by
  some values from: CHEK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
directly activates: Catalysis819

Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: enabled by
  some values from: UniProt:P30291 WEE1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
directly activates: BiochemicalReaction1942
directly activates: Control139

G2/M DNA damage checkpoint
type: GO_0008150

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
type: GO_0008150
BFO_0000050: G2/M DNA damage checkpoint