@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (46)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P30291
	rdfs:label "UniProt:P30291 WEE1"@em ,
		   "WEE1"@em .

obo:UniProtKB_P30304
	rdfs:label "CDC25A"@em ,
		   "UniProt:P30304 CDC25A"@em .

obo:UniProtKB_Q99640
	rdfs:label "MYT1"@em ,
		   "PKMYT1"@em ,
		   "UniProt:Q99640 PKMYT1"@em .

biopax:BiochemicalReaction15
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction16 ,
			       biopax:BiochemicalReaction17 ;
	rdfs:label "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7"@em .

biopax:BiochemicalReaction16
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction50 ;
	rdfs:label "Cdt1 is displaced from the pre-replicative complex."@em .

biopax:BiochemicalReaction17
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction18 ,
			       biopax:BiochemicalReaction19 ,
			       biopax:Catalysis4 ;
	rdfs:label "CDK and DDK associate with the Mcm10:pre-replicative complex"@em .

biopax:BiochemicalReaction18
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	rdfs:label "Mcm2-7 is phosphorylated by DDK"@em .

biopax:BiochemicalReaction1840
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004861 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1894 ,
			       biopax:Catalysis831 ;
	rdfs:label "Inactivation of Cyclin E:Cdk2 complexes by p27/p21"@em .

biopax:BiochemicalReaction1890
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1891 ;
	rdfs:label "Formation of Cyclin E:Cdk2 complexes"@em .

biopax:BiochemicalReaction1891
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1840 ,
			       biopax:BiochemicalReaction1899 ,
			       biopax:BiochemicalReaction1903 ,
			       biopax:Catalysis808 ,
			       biopax:Catalysis834 ,
			       biopax:Catalysis838 ;
	rdfs:label "Translocation of Cyclin E:Cdk2 complex to the nucleus"@em .

biopax:BiochemicalReaction1892
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1840 ,
			       biopax:BiochemicalReaction1917 ,
			       biopax:Catalysis808 ,
			       biopax:Catalysis845 ;
	rdfs:label "Translocation of p21 to the nucleus"@em .

biopax:BiochemicalReaction1893
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1840 ,
			       biopax:BiochemicalReaction1917 ,
			       biopax:Catalysis808 ,
			       biopax:Catalysis845 ;
	rdfs:label "Translocation of p27 to the nucleoplasm"@em .

biopax:BiochemicalReaction1894
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway446 ;
	obo:directly_activates biopax:BiochemicalReaction1896 ;
	rdfs:label "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21"@em .

biopax:BiochemicalReaction1895
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway446 ;
	obo:directly_activates biopax:BiochemicalReaction1896 ;
	rdfs:label "Association of Cks1 with SCF(Skp2) complex"@em .

biopax:BiochemicalReaction1896
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway446 ;
	obo:directly_activates biopax:BiochemicalReaction1897 ,
			       biopax:Catalysis832 ;
	rdfs:label "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex"@em .

biopax:BiochemicalReaction1897
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway446 ;
	obo:directly_activates biopax:BiochemicalReaction1898 ,
			       biopax:Catalysis833 ;
	rdfs:label "Ubiquitination of phospho-p27/p21"@em .

biopax:BiochemicalReaction1898
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004175 ;
	obo:BFO_0000050 biopax:Pathway446 ;
	obo:directly_activates biopax:BiochemicalReaction1903 ,
			       biopax:BiochemicalReaction1915 ,
			       biopax:Catalysis838 ,
			       biopax:Catalysis843 ;
	rdfs:label "Degradation of ubiquitinated p27/p21 by the 26S proteasome"@em .

biopax:BiochemicalReaction1899
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P30291
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P30291
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1902 ,
			       biopax:Catalysis837 ;
	rdfs:label "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1"@em .

biopax:BiochemicalReaction19
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction20 ;
	rdfs:label "Cdc45 associates with the pre-replicative complex at the origin"@em .

biopax:BiochemicalReaction1900
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q99640
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q99640
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	rdfs:label "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1"@em .

biopax:BiochemicalReaction1901
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q99640
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_Q99640
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	rdfs:label "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1"@em .

biopax:BiochemicalReaction1902
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P30304
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:enabled_by ;
	    owl:someValuesFrom obo:UniProtKB_P30304
	  ] ,
	  obo:GO_0004721 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1840 ,
			       biopax:BiochemicalReaction1841 ,
			       biopax:BiochemicalReaction1903 ,
			       biopax:Catalysis808 ,
			       biopax:Catalysis809 ,
			       biopax:Catalysis838 ,
			       biopax:Pathway447 ;
	rdfs:label "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"@em .

biopax:BiochemicalReaction1903
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1904 ,
			       biopax:Pathway447 ;
	rdfs:label "CAK-mediated phosphorylation of Cyclin E:Cdk2"@em .

biopax:BiochemicalReaction1904
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1905 ,
			       biopax:Catalysis839 ;
	rdfs:label "Association of Rb with Cyclin E:Cdk2 complexes"@em .

biopax:BiochemicalReaction1905
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway447 ;
	rdfs:label "Cyclin E:Cdk2-mediated phosphorylation of Rb"@em .

biopax:BiochemicalReaction1906
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway451 ;
	obo:directly_activates biopax:BiochemicalReaction1907 ,
			       biopax:Catalysis840 ;
	rdfs:label "Detection of damage during initiation of DNA synthesis in S-phase"@em .

biopax:BiochemicalReaction1907
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004721 ;
	obo:BFO_0000050 biopax:Pathway451 ;
	obo:directly_activates biopax:BiochemicalReaction1908 ;
	rdfs:label "PP2A mediated localization of RB1 protein in chromatin"@em .

biopax:BiochemicalReaction1908
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway451 ;
	rdfs:label "Replication initiation regulation by Rb1/E2F1"@em .

biopax:BiochemicalReaction1909
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway452 ;
	obo:directly_activates biopax:BiochemicalReaction1910 ;
	rdfs:label "Activation of Cyclin B/Cdk1 by Cdc25a (string) protein"@em .

biopax:BiochemicalReaction1910
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway452 ;
	rdfs:label "Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation"@em .

biopax:BiochemicalReaction20
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction21 ,
			       biopax:BiochemicalReaction22 ,
			       biopax:Control1 ,
			       biopax:Control2 ;
	rdfs:label "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin"@em .

biopax:BiochemicalReaction21
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction23 ,
			       biopax:Catalysis5 ;
	rdfs:label "DNA polymerase alpha:primase binds at the origin"@em .

biopax:BiochemicalReaction22
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	rdfs:label "DNA polymerase epsilon binds at the origin"@em .

biopax:Pathway444
	a obo:GO_0008150 ;
	rdfs:label "G1/S Transition"@em .

biopax:Pathway445
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway444 ;
	rdfs:label "Cyclin E associated events during G1/S transition"@em .

biopax:Pathway446
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	rdfs:label "SCF(Skp2)-mediated degradation of p27/p21"@em .

biopax:Pathway447
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	rdfs:label "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes"@em .

biopax:Pathway448
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	rdfs:label "Ubiquitin-Dependent Degradation of Cyclin E"@em .

biopax:Pathway449
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway444 ;
	rdfs:label "G1/S-Specific Transcription"@em .

biopax:Pathway450
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway444 ;
	rdfs:label "E2F mediated regulation of DNA replication"@em .

biopax:Pathway451
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway450 ;
	rdfs:label "Inhibition of replication initiation of damaged DNA by RB1/E2F1"@em .

biopax:Pathway452
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway450 ;
	rdfs:label "E2F-enabled inhibition of pre-replication complex formation"@em .

biopax:Pathway8
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway444 ;
	rdfs:label "Activation of the pre-replicative complex"@em .

biopax:TemplateReaction33
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway445 ;
	obo:directly_activates biopax:BiochemicalReaction1902 ,
			       biopax:BiochemicalReaction1914 ,
			       biopax:Catalysis837 ,
			       biopax:Catalysis842 ;
	rdfs:label "Activation of Cdc25A by c-myc"@em .

biopax:TemplateReaction34
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway449 ,
			biopax:Pathway450 ;
	obo:directly_activates biopax:BiochemicalReaction1890 ,
			       biopax:BiochemicalReaction19 ,
			       biopax:BiochemicalReaction1909 ,
			       biopax:BiochemicalReaction2018 ,
			       biopax:BiochemicalReaction21 ,
			       biopax:BiochemicalReaction7 ,
			       biopax:Control1 ;
	rdfs:label "Activation of E2F target genes at G1/S"@em .