@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (14)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction1879
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1880 ;
	rdfs:label "Formation of Cyclin D:Cdk4/6 complexes"@em .

biopax:BiochemicalReaction1880
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1881 ,
			       biopax:Catalysis824 ;
	rdfs:label "Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus"@em .

biopax:BiochemicalReaction1881
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1882 ,
			       biopax:Catalysis825 ;
	rdfs:label "Phosphorylation of Cyclin D:Cdk4/6 complexes"@em .

biopax:BiochemicalReaction1882
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:Pathway449 ,
			       biopax:Pathway456 ,
			       biopax:TemplateReaction1 ,
			       biopax:TemplateReaction150 ,
			       biopax:TemplateReaction152 ,
			       biopax:TemplateReactionRegulation1 ,
			       biopax:TemplateReactionRegulation174 ,
			       biopax:TemplateReactionRegulation176 ;
	rdfs:label "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes"@em .

biopax:BiochemicalReaction1883
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	rdfs:label "Association of INK4A with Cdk4/6"@em .

biopax:BiochemicalReaction1884
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1885 ,
			       biopax:Catalysis827 ;
	rdfs:label "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex"@em .

biopax:BiochemicalReaction1885
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004721 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	rdfs:label "Dephosphorylation of p107 (RBL1) by PP2A"@em ,
		   "Dephosphorylation of p107 by PP2A"@em .

biopax:BiochemicalReaction1886
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004693 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1887 ,
			       biopax:BiochemicalReaction1888 ,
			       biopax:Catalysis829 ;
	rdfs:label "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex"@em .

biopax:BiochemicalReaction1887
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004721 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	rdfs:label "Dephosphorylation of p107 by PP2A"@em ,
		   "Dephosphorylation of p130 (RBL2) by PP2A"@em .

biopax:BiochemicalReaction1888
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	obo:directly_activates biopax:BiochemicalReaction1889 ,
			       biopax:Catalysis830 ;
	rdfs:label "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex"@em .

biopax:BiochemicalReaction1889
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0004842 ;
	obo:BFO_0000050 biopax:Pathway443 ;
	rdfs:label "Ubiquitination of p130 (RBL2) by SCF (Skp2)"@em .

biopax:Pathway442
	a obo:GO_0008150 ;
	rdfs:label "G1 Phase"@em .

biopax:Pathway443
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway442 ;
	rdfs:label "Cyclin D associated events in G1"@em .