FASL binds FAS Receptor
Trimerization of the FASL:FAS receptor complex
FasL:Fas binds FADD
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
TNF-alpha cleavage by TACE
Soluble TNF-alpha binds TNF-R1
Membrane-anchored TNF-alpha binds TNF-R1
TNF:TNF-R1 binds TRADD, TRAF2 and RIP
TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
TRADD:TRAF2:RIP1 complex binds FADD
TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
TRAIL Binds TRAIL-Receptor2
Trimerization of TRAIL: TRAIL receptor-2 complex
TRAIL:TRAIL receptor-2 Trimer Binds FADD
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
FAS-mediated dimerization of procaspase-8
TRAIL-mediated dimerization of procaspase-8
TNF-mediated dimerization of procaspase-8
Caspase-8 processing
FLIP(L) and procaspase-8 form heterodimer in TNF signaling
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
Caspase-8 and FLIP(L) processing at DISC
FLIP(S) and procaspase-8 form heterodimer
Extrinsic Pathway for Apoptosis
Death Receptor Signalling
FasL/ CD95L signaling
TNF signaling
TRAIL signaling
Caspase-8 activation
Dimerization of procaspase-8
Regulation by c-FLIP