FASL binds FAS Receptor
type: GO_0097190
BFO_0000050: FasL/ CD95L signaling
directly activates: Trimerization of the FASL:FAS receptor complex

Trimerization of the FASL:FAS receptor complex
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FasL:Fas binds FADD

FasL:Fas binds FADD
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
directly activates: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
directly activates: Control490

FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling
directly activates: FAS-mediated dimerization of procaspase-8
directly activates: TRAIL-mediated dimerization of procaspase-8
directly activates: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer
directly activates: Control494
directly activates: Control495

FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10
type: GO_0003674
BFO_0000050: FasL/ CD95L signaling

TNF-alpha cleavage by TACE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004222
BFO_0000050: TNF signaling
directly activates: Soluble TNF-alpha binds TNF-R1

Soluble TNF-alpha binds TNF-R1
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF:TNF-R1 binds TRADD, TRAF2 and RIP
directly activates: Control491

Membrane-anchored TNF-alpha binds TNF-R1
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF:TNF-R1 binds TRADD, TRAF2 and RIP
directly activates: Control491

TNF:TNF-R1 binds TRADD, TRAF2 and RIP
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.

TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1 complex binds FADD

TRADD:TRAF2:RIP1 complex binds FADD
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8

TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
type: GO_0003674
BFO_0000050: TNF signaling
directly activates: TNF-mediated dimerization of procaspase-8
directly activates: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer
directly activates: Control496

TRAIL Binds TRAIL-Receptor2
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: Trimerization of TRAIL: TRAIL receptor-2 complex
directly activates: TRAIL:TRAIL receptor-2 Trimer Binds FADD
directly activates: Control492

Trimerization of TRAIL: TRAIL receptor-2 complex
type: GO_0003674
BFO_0000050: TRAIL signaling

TRAIL:TRAIL receptor-2 Trimer Binds FADD
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
directly activates: TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
directly activates: Control493

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8
type: GO_0003674
BFO_0000050: TRAIL signaling
directly activates: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
directly activates: FLIP(S) and procaspase-8 form heterodimer

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10
type: GO_0003674
BFO_0000050: TRAIL signaling

FAS-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

TRAIL-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

TNF-mediated dimerization of procaspase-8
type: GO_0003674
BFO_0000050: Dimerization of procaspase-8
directly activates: Caspase-8 processing
directly activates: Catalysis3105
directly activates: Control497

Caspase-8 processing
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Caspase-8 activation
directly activates: BiochemicalReaction6000
directly activates: BiochemicalReaction6042
directly activates: BiochemicalReaction6045
directly activates: BiochemicalReaction6088
directly activates: Catalysis3107
directly activates: Catalysis3121
directly activates: Catalysis3124

FLIP(L) and procaspase-8 form heterodimer in TNF signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
type: GO_0003674
BFO_0000050: Regulation by c-FLIP
directly activates: Caspase-8 and FLIP(L) processing at DISC
directly activates: Catalysis3106

Caspase-8 and FLIP(L) processing at DISC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004197
BFO_0000050: Regulation by c-FLIP

FLIP(S) and procaspase-8 form heterodimer
type: GO_1902042
BFO_0000050: Regulation by c-FLIP

Extrinsic Pathway for Apoptosis
type: GO_0008150

Death Receptor Signalling
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis

FasL/ CD95L signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

TNF signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

TRAIL signaling
type: GO_0008150
BFO_0000050: Death Receptor Signalling

Caspase-8 activation
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis

Dimerization of procaspase-8
type: GO_0008150
BFO_0000050: Caspase-8 activation

Regulation by c-FLIP
type: GO_0008150
BFO_0000050: Extrinsic Pathway for Apoptosis