@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (35)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction5974
	a obo:GO_0097190 ;
	obo:BFO_0000050 biopax:Pathway1372 ;
	obo:directly_activates biopax:BiochemicalReaction5975 ;
	rdfs:label "FASL binds FAS Receptor"@em .

biopax:BiochemicalReaction5975
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1372 ;
	obo:directly_activates biopax:BiochemicalReaction5976 ;
	rdfs:label "Trimerization of the FASL:FAS receptor complex"@em .

biopax:BiochemicalReaction5976
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1372 ;
	obo:directly_activates biopax:BiochemicalReaction5977 ,
			       biopax:BiochemicalReaction5978 ,
			       biopax:Control490 ;
	rdfs:label "FasL:Fas binds FADD"@em .

biopax:BiochemicalReaction5977
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1372 ;
	obo:directly_activates biopax:BiochemicalReaction5991 ,
			       biopax:BiochemicalReaction5992 ,
			       biopax:BiochemicalReaction5997 ,
			       biopax:BiochemicalReaction5999 ,
			       biopax:Control494 ,
			       biopax:Control495 ;
	rdfs:label "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8"@em .

biopax:BiochemicalReaction5978
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1372 ;
	rdfs:label "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-10"@em .

biopax:BiochemicalReaction5979
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005886
	  ] ,
	  obo:GO_0004222 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5980 ;
	rdfs:label "TNF-alpha cleavage by TACE"@em .

biopax:BiochemicalReaction5980
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5982 ,
			       biopax:Control491 ;
	rdfs:label "Soluble TNF-alpha binds TNF-R1"@em .

biopax:BiochemicalReaction5981
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5982 ,
			       biopax:Control491 ;
	rdfs:label "Membrane-anchored TNF-alpha binds TNF-R1"@em .

biopax:BiochemicalReaction5982
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5983 ;
	rdfs:label "TNF:TNF-R1 binds TRADD, TRAF2 and RIP"@em .

biopax:BiochemicalReaction5983
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5984 ;
	rdfs:label "TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex."@em .

biopax:BiochemicalReaction5984
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5985 ;
	rdfs:label "TRADD:TRAF2:RIP1 complex binds FADD"@em .

biopax:BiochemicalReaction5985
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1373 ;
	obo:directly_activates biopax:BiochemicalReaction5993 ,
			       biopax:BiochemicalReaction5995 ,
			       biopax:BiochemicalReaction5999 ,
			       biopax:Control496 ;
	rdfs:label "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8"@em .

biopax:BiochemicalReaction5986
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1374 ;
	obo:directly_activates biopax:BiochemicalReaction5987 ,
			       biopax:BiochemicalReaction5988 ,
			       biopax:Control492 ;
	rdfs:label "TRAIL Binds TRAIL-Receptor2"@em .

biopax:BiochemicalReaction5987
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1374 ;
	rdfs:label "Trimerization of TRAIL: TRAIL receptor-2 complex"@em .

biopax:BiochemicalReaction5988
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1374 ;
	obo:directly_activates biopax:BiochemicalReaction5989 ,
			       biopax:BiochemicalReaction5990 ,
			       biopax:Control493 ;
	rdfs:label "TRAIL:TRAIL receptor-2 Trimer Binds FADD"@em .

biopax:BiochemicalReaction5989
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1374 ;
	obo:directly_activates biopax:BiochemicalReaction5996 ,
			       biopax:BiochemicalReaction5999 ;
	rdfs:label "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-8"@em .

biopax:BiochemicalReaction5990
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1374 ;
	rdfs:label "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds Caspase-10"@em .

biopax:BiochemicalReaction5991
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1376 ;
	obo:directly_activates biopax:BiochemicalReaction5994 ,
			       biopax:Catalysis3105 ,
			       biopax:Control497 ;
	rdfs:label "FAS-mediated dimerization of procaspase-8"@em .

biopax:BiochemicalReaction5992
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1376 ;
	obo:directly_activates biopax:BiochemicalReaction5994 ,
			       biopax:Catalysis3105 ,
			       biopax:Control497 ;
	rdfs:label "TRAIL-mediated dimerization of procaspase-8"@em .

biopax:BiochemicalReaction5993
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1376 ;
	obo:directly_activates biopax:BiochemicalReaction5994 ,
			       biopax:Catalysis3105 ,
			       biopax:Control497 ;
	rdfs:label "TNF-mediated dimerization of procaspase-8"@em .

biopax:BiochemicalReaction5994
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004197 ;
	obo:BFO_0000050 biopax:Pathway1375 ;
	obo:directly_activates biopax:BiochemicalReaction6000 ,
			       biopax:BiochemicalReaction6042 ,
			       biopax:BiochemicalReaction6045 ,
			       biopax:BiochemicalReaction6088 ,
			       biopax:Catalysis3107 ,
			       biopax:Catalysis3121 ,
			       biopax:Catalysis3124 ;
	rdfs:label "Caspase-8 processing"@em .

biopax:BiochemicalReaction5995
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1377 ;
	obo:directly_activates biopax:BiochemicalReaction5998 ,
			       biopax:Catalysis3106 ;
	rdfs:label "FLIP(L) and procaspase-8 form heterodimer in TNF signaling"@em .

biopax:BiochemicalReaction5996
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1377 ;
	obo:directly_activates biopax:BiochemicalReaction5998 ,
			       biopax:Catalysis3106 ;
	rdfs:label "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling"@em .

biopax:BiochemicalReaction5997
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway1377 ;
	obo:directly_activates biopax:BiochemicalReaction5998 ,
			       biopax:Catalysis3106 ;
	rdfs:label "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling"@em .

biopax:BiochemicalReaction5998
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0004197 ;
	obo:BFO_0000050 biopax:Pathway1377 ;
	rdfs:label "Caspase-8 and FLIP(L) processing at DISC"@em .

biopax:BiochemicalReaction5999
	a obo:GO_1902042 ;
	obo:BFO_0000050 biopax:Pathway1377 ;
	rdfs:label "FLIP(S) and procaspase-8 form heterodimer"@em .

biopax:Pathway1370
	a obo:GO_0008150 ;
	rdfs:label "Extrinsic Pathway for Apoptosis"@em .

biopax:Pathway1371
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1370 ;
	rdfs:label "Death Receptor  Signalling"@em .

biopax:Pathway1372
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1371 ;
	rdfs:label "FasL/ CD95L signaling"@em .

biopax:Pathway1373
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1371 ;
	rdfs:label "TNF signaling"@em .

biopax:Pathway1374
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1371 ;
	rdfs:label "TRAIL  signaling"@em .

biopax:Pathway1375
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1370 ;
	rdfs:label "Caspase-8 activation"@em .

biopax:Pathway1376
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1375 ;
	rdfs:label "Dimerization of procaspase-8"@em .

biopax:Pathway1377
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway1370 ;
	rdfs:label "Regulation by c-FLIP"@em .