Detection of damage during initiation of DNA synthesis in S-phase
PP2A mediated localization of RB1 protein in chromatin
Replication initiation regulation by Rb1/E2F1
Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
E2F mediated regulation of DNA replication
Inhibition of replication initiation of damaged DNA by RB1/E2F1
E2F-enabled inhibition of pre-replication complex formation
Activation of E2F target genes at G1/S