Detection of damage during initiation of DNA synthesis in S-phase
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: PP2A mediated localization of RB1 protein in chromatin
directly activates: Catalysis840

PP2A mediated localization of RB1 protein in chromatin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004721
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1
directly activates: Replication initiation regulation by Rb1/E2F1

Replication initiation regulation by Rb1/E2F1
type: GO_0003674
BFO_0000050: Inhibition of replication initiation of damaged DNA by RB1/E2F1

Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation
directly activates: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation

Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
type: GO_0003674
BFO_0000050: E2F-enabled inhibition of pre-replication complex formation

E2F mediated regulation of DNA replication
type: GO_0008150

Inhibition of replication initiation of damaged DNA by RB1/E2F1
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

E2F-enabled inhibition of pre-replication complex formation
type: GO_0008150
BFO_0000050: E2F mediated regulation of DNA replication

Activation of E2F target genes at G1/S
type: GO_0003674
BFO_0000050: E2F mediated regulation of DNA replication
directly activates: BiochemicalReaction1890
directly activates: BiochemicalReaction19
directly activates: Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
directly activates: BiochemicalReaction2018
directly activates: BiochemicalReaction21
directly activates: BiochemicalReaction7
directly activates: Control1