@prefix owl: . @prefix rdfs: . @prefix rdf: . @prefix biopax: . @prefix obo: . # Named toplevel resources (68) a owl:Ontology ; owl:imports , . biopax:BiochemicalReaction1003 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway287 ; obo:directly_activates biopax:BiochemicalReaction1007 ; rdfs:label "Ficolin-1 binds to molecular patterns on the target cell surface"@em . biopax:BiochemicalReaction1004 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway287 ; obo:directly_activates biopax:BiochemicalReaction1007 ; rdfs:label "Ficolin-2 binds to molecular patterns on the target cell surface"@em . biopax:BiochemicalReaction1005 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway287 ; obo:directly_activates biopax:BiochemicalReaction1007 ; rdfs:label "Ficolin-3 binds to molecular patterns on the target cell surface"@em . biopax:BiochemicalReaction1006 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway286 ; obo:directly_activates biopax:BiochemicalReaction1007 ; rdfs:label "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa"@em . biopax:BiochemicalReaction1007 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway286 ; obo:directly_activates biopax:BiochemicalReaction1010 , biopax:BiochemicalReaction1012 , biopax:Catalysis383 , biopax:Catalysis384 ; rdfs:label "Activation of MASPs"@em . biopax:BiochemicalReaction1008 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway288 ; obo:directly_activates biopax:BiochemicalReaction1009 , biopax:Catalysis382 ; rdfs:label "Activation of C1R"@em . biopax:BiochemicalReaction1009 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway288 ; obo:directly_activates biopax:BiochemicalReaction1010 , biopax:Catalysis383 ; rdfs:label "Activation of C1S"@em . biopax:BiochemicalReaction1010 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway284 ; obo:directly_activates biopax:BiochemicalReaction1011 , biopax:BiochemicalReaction1059 ; rdfs:label "Conversion of C4 into C4a and C4b"@em . biopax:BiochemicalReaction1011 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway284 ; obo:directly_activates biopax:BiochemicalReaction1013 ; rdfs:label "C4b binds to cell surface"@em . biopax:BiochemicalReaction1012 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway284 ; obo:directly_activates biopax:BiochemicalReaction1013 ; rdfs:label "Conversion of C2 into C2a and C2b"@em . biopax:BiochemicalReaction1013 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway284 ; obo:directly_activates biopax:BiochemicalReaction1028 , biopax:BiochemicalReaction1031 , biopax:BiochemicalReaction1043 , biopax:BiochemicalReaction1048 , biopax:Catalysis389 ; rdfs:label "Formation of Classical C3 convertase (C4b:C2a complex)"@em . biopax:BiochemicalReaction1014 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1015 ; rdfs:label "Spontaneous hydrolysis of C3 thioester"@em . biopax:BiochemicalReaction1015 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1016 , biopax:Catalysis385 ; rdfs:label "Factor B binds to C3(H2O)"@em . biopax:BiochemicalReaction1016 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1017 , biopax:BiochemicalReaction1035 , biopax:BiochemicalReaction1043 , biopax:BiochemicalReaction1048 , biopax:Catalysis386 , biopax:Control77 ; rdfs:label "Factor D cleaves C3(H2O)-bound Factor B"@em . biopax:BiochemicalReaction1017 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1018 ; rdfs:label "C3(H2O):Factor Bb cleaves C3 to C3b and C3a"@em . biopax:BiochemicalReaction1018 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1019 , biopax:BiochemicalReaction1034 , biopax:Control76 ; rdfs:label "C3b binds to cell surface"@em . biopax:BiochemicalReaction1019 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1020 , biopax:Catalysis387 ; rdfs:label "Factor B binds to surface-associated C3b"@em . biopax:BiochemicalReaction1020 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1021 , biopax:BiochemicalReaction1035 , biopax:BiochemicalReaction1043 , biopax:BiochemicalReaction1048 , biopax:Control77 ; rdfs:label "Factor D cleaves C3b-bound Factor B"@em . biopax:BiochemicalReaction1021 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1022 , biopax:BiochemicalReaction1028 , biopax:BiochemicalReaction1031 , biopax:Catalysis388 , biopax:Catalysis389 ; rdfs:label "Properdin stabilizes C3b:Bb bound to cell surfaces"@em . biopax:BiochemicalReaction1022 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway289 ; obo:directly_activates biopax:BiochemicalReaction1028 , biopax:BiochemicalReaction1030 , biopax:BiochemicalReaction1031 , biopax:Catalysis389 , biopax:Catalysis390 ; rdfs:label "Formation of alternative pathway C5 convertase"@em . biopax:BiochemicalReaction1023 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway290 ; obo:directly_activates biopax:BiochemicalReaction1024 ; rdfs:label "Formation of C5b:C6 complex"@em . biopax:BiochemicalReaction1024 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway290 ; obo:directly_activates biopax:BiochemicalReaction1025 , biopax:BiochemicalReaction1058 ; rdfs:label "Formation of C5b:C6:C7 complex"@em . biopax:BiochemicalReaction1025 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway290 ; obo:directly_activates biopax:BiochemicalReaction1026 ; rdfs:label "C7 allows complex to insert into membrane under attack"@em . biopax:BiochemicalReaction1026 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway290 ; obo:directly_activates biopax:BiochemicalReaction1027 , biopax:BiochemicalReaction1056 ; rdfs:label "Formation of C5b:C6:C7:C8 complex"@em . biopax:BiochemicalReaction1027 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway290 ; rdfs:label "Creation of the Membrane Attack Complex (MAC)"@em . biopax:BiochemicalReaction1028 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway291 ; obo:directly_activates biopax:BiochemicalReaction1029 , biopax:BiochemicalReaction1032 , biopax:BiochemicalReaction4196 , biopax:Pathway290 ; rdfs:label "Cleavage of C3 by C3 convertases"@em . biopax:BiochemicalReaction1029 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway291 ; obo:directly_activates biopax:BiochemicalReaction1030 , biopax:BiochemicalReaction1031 , biopax:Catalysis390 ; rdfs:label "Formation of classic pathway C5 convertase"@em . biopax:BiochemicalReaction1030 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway291 ; obo:directly_activates biopax:BiochemicalReaction1023 , biopax:BiochemicalReaction4195 ; rdfs:label "Activation of C5"@em . biopax:BiochemicalReaction1031 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "C3 convertases spontaneously dissociate"@em . biopax:BiochemicalReaction1032 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1038 ; rdfs:label "Factor H binds to C3b"@em . biopax:BiochemicalReaction1033 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1034 , biopax:Control76 ; rdfs:label "Factor H binds host cell surface markers"@em . biopax:BiochemicalReaction1034 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1040 ; rdfs:label "Factor H binds to membrane-associated C3b"@em . biopax:BiochemicalReaction1035 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1036 ; rdfs:label "Factor H binds to C3bBb"@em . biopax:BiochemicalReaction1036 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Factor H displaces Bb"@em . biopax:BiochemicalReaction1037 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1038 , biopax:BiochemicalReaction1040 ; rdfs:label "Complement factor I complex formation"@em . biopax:BiochemicalReaction1038 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1039 , biopax:Catalysis391 ; rdfs:label "Complement factor I binds to extracellular Factor H:C3b"@em . biopax:BiochemicalReaction1039 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005576 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Factor I inactivates plasma Factor H-bound C3b"@em . biopax:BiochemicalReaction1040 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1041 , biopax:Catalysis392 ; rdfs:label "Complement factor I binds to membrane-associated Factor H:C3b"@em . biopax:BiochemicalReaction1041 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Factor I inactivates Factor H-boundC3b"@em . biopax:BiochemicalReaction1042 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "iC3b proteolysis"@em . biopax:BiochemicalReaction1043 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1044 ; rdfs:label "CR1 binds C3bBb/C4bC2a"@em . biopax:BiochemicalReaction1044 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1046 ; rdfs:label "Displacement of C2a/Bb by CR1"@em . biopax:BiochemicalReaction1045 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1046 ; rdfs:label "MCP binds C3b, C4b"@em . biopax:BiochemicalReaction1046 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1047 , biopax:Catalysis393 ; rdfs:label "Complement factor I binds to MCP, CR1:C4b, C3b"@em . biopax:BiochemicalReaction1047 a [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , [ a owl:Restriction ; owl:onProperty obo:BFO_0000066 ; owl:someValuesFrom obo:GO_0005886 ] , obo:GO_0004252 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1042 ; rdfs:label "Factor I inactivates MCP/CR1-bound C4b/C3b"@em . biopax:BiochemicalReaction1048 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1049 ; rdfs:label "DAF binds C3bBb, C4bC2a"@em . biopax:BiochemicalReaction1049 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "DAF accelerates C3bBb/C4bC2a dissociation"@em . biopax:BiochemicalReaction1050 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1051 ; rdfs:label "C4b-binding protein binds C4b"@em . biopax:BiochemicalReaction1051 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1052 ; rdfs:label "Complement factor I binds C4BP"@em . biopax:BiochemicalReaction1052 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Complement factor I inactivates C4BP-bound C4b"@em . biopax:BiochemicalReaction1053 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; obo:directly_activates biopax:BiochemicalReaction1054 ; rdfs:label "C4b binding protein binds C4bC2a"@em . biopax:BiochemicalReaction1054 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "C4b binding protein displaces C2a"@em . biopax:BiochemicalReaction1055 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "C4b binding protein binds Protein S"@em . biopax:BiochemicalReaction1056 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "CD59 inhibits MAC formation"@em . biopax:BiochemicalReaction1057 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Formation of soluble VTN:C5b-C9"@em . biopax:BiochemicalReaction1058 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Vitronectin(VTN) binds to C5b:C6:C7"@em . biopax:BiochemicalReaction1059 a obo:GO_0003674 ; obo:BFO_0000050 biopax:Pathway292 ; rdfs:label "Hydrolysis of internal thioester in C4b"@em . biopax:Pathway283 a obo:GO_0008150 ; rdfs:label "Complement cascade"@em . biopax:Pathway284 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway283 ; rdfs:label "Initial triggering of complement"@em . biopax:Pathway285 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway284 ; rdfs:label "Creation of C4 and C2 activators"@em . biopax:Pathway286 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway285 ; rdfs:label "Lectin pathway of complement activation"@em . biopax:Pathway287 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway286 ; rdfs:label "Ficolins bind to repetitive carbohydrate structures on the target cell surface"@em . biopax:Pathway288 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway285 ; rdfs:label "Classical antibody-mediated complement activation"@em . biopax:Pathway289 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway284 ; rdfs:label "Alternative complement activation"@em . biopax:Pathway290 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway283 ; rdfs:label "Terminal pathway of complement"@em . biopax:Pathway291 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway283 ; rdfs:label "Activation of C3 and C5"@em . biopax:Pathway292 a obo:GO_0008150 ; obo:BFO_0000050 biopax:Pathway283 ; rdfs:label "Regulation of Complement cascade"@em .