CHEK1
CHK1
UniProt:O14757 CHEK1
CDS1
CHEK2
CHK2
RAD53
UniProt:O96017-12 CHEK2
LIG1
UniProt:P18858 LIG1
UniProt:P30291 WEE1
WEE1
CDC25A
UniProt:P30304 CDC25A
FEN1
RAD2
UniProt:P39748 FEN1
PLK
PLK1
UniProt:P53350 PLK1
ATM
UniProt:Q13315 ATM
DYRK
DYRK1A
MNB
MNBH
UniProt:Q13627 DYRK1A
ESP1
ESPL1
KIAA0165
UniProt:Q14674 ESPL1
COP1
RFWD2
RNF200
UniProt:Q8NHY2 RFWD2
GWL
MASTL
THC2
UniProt:Q96GX5 MASTL
MYT1
PKMYT1
UniProt:Q99640 PKMYT1
MCM8
UniProt:Q9UJA3 MCM8
CDC6 association with ORC:origin complexes mediated by MCM8
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Ubiquitinated geminin is degraded by the proteasome
Free CDT1 associates with CDC6:ORC:origin complexes
Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
Cdt1 is displaced from the pre-replicative complex.
CDK and DDK associate with the Mcm10:pre-replicative complex
Mcm2-7 is phosphorylated by DDK
Phosphorylation of p53 at ser-15 by ATM kinase
Phosphorylation of MDM2 at serine-395 by ATM kinase
Phosphorylation of COP1 at Ser-387 by ATM
Dissociation of the COP1-p53 complex
Translocation of COP1 from the nucleus to the cytoplasm
Autoubiquitination of phospho-COP1(Ser-387 )
Proteasome mediated degradation of COP1
Inactivation of Cyclin E:Cdk2 complexes by p27/p21
Phosphorylation of Cdc25A at Ser-123 in response to DNA damage
Phosphorylation of Cdc25A at Ser-123 by Chk2
Ubiquitination of phosphorylated Cdc25A
Proteolytic degradation of ubiquitinated-Cdc25A
Phosphorylation and activation of Chk1 by ATM
Phosphorylation of Cdc25A at Ser-123 by Chk1
Recruitment and activation of Chk1
Phosphorylation and activation of CHK2 by ATM
Phosphorylation of Cdc25C at Ser216
Association of phospho-Cdc25C(Ser 216) with 14-3-3 proteins
Retention of phospho-Cdc25C:14-3-3 complexes within the cytoplasm
Phosphorylation of Wee1 kinase by Chk1
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
Stalling of DNA replication fork and RPA binding
Binding of ATR-ATRIP to the RPA-ssDNA complex
Recruitment of Rad17-RFC complex to DNA
Recruitment of the 9-1-1 complex to DNA
Recruitment of the Rad9-Hus1-Rad1 complex to DNA
Loading of claspin onto DNA during replication origin firing
Activation of claspin
Phosphorylation of Cdc25C at Ser 216 by Chk1
Mad1 binds kinetochore
MAD2 associates with the Mad1 kinetochore complex
MAD2 converted to an inhibitory state via interaction with Mad1
Release of activated MAD2 from kinetochores
Inactivation of APC/C via CDC20 sequestration
Formation of the MCC complex
Binding of the MCC complex to the APC/C complex
Phosphorylation of LIN52 component of MuvB by DYRK1A
p130 (RBL2) associates with MuvB to form DREAM complex
Transcription of E2F targets under negative control by DREAM complex
HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
Recruitment of HDAC1 by p107 (RBL1)
HDAC1 + p130(RBL2):E2F4/5:DP1 => HDAC1-p130(RBL2):E2F4/5:DP1
Recruitment of HDAC1 by p130 (RBL2)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
p107 (RBL1) binds CyclinE/A:CDK2
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
p130 (RBL2) binds Cyclin E/A:CDK2
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2
Formation of Cyclin D:Cdk4/6 complexes
Translocation of Cyclin D:Cdk4/6 complexes from the cytoplasm to the nucleus
Phosphorylation of Cyclin D:Cdk4/6 complexes
Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes
Association of INK4A with Cdk4/6
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
Dephosphorylation of p107 (RBL1) by PP2A
Dephosphorylation of p107 by PP2A
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
Dephosphorylation of p130 (RBL2) by PP2A
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
Ubiquitination of p130 (RBL2) by SCF (Skp2)
Formation of Cyclin E:Cdk2 complexes
Translocation of Cyclin E:Cdk2 complex to the nucleus
Translocation of p21 to the nucleus
Translocation of p27 to the nucleoplasm
Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
Association of Cks1 with SCF(Skp2) complex
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Ubiquitination of phospho-p27/p21
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1
Cdc45 associates with the pre-replicative complex at the origin
Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1
Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
CAK-mediated phosphorylation of Cyclin E:Cdk2
Association of Rb with Cyclin E:Cdk2 complexes
Cyclin E:Cdk2-mediated phosphorylation of Rb
Detection of damage during initiation of DNA synthesis in S-phase
PP2A mediated localization of RB1 protein in chromatin
Replication initiation regulation by Rb1/E2F1
Activation of Cyclin B/Cdk1 by Cdc25a (string) protein
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation
Formation of Cyclin A:Cdk2 complexes
Translocation of Cyclin A:Cdk2 complexes to the nucleus
Phosphorylation of Cyclin A:Cdk2 at Tyr 15
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
CAK-mediated phosphorylation of Cyclin A:Cdk2
Cyclin A:Cdk2 mediated phosphorylation of p27/p21
Inactivation of Cyclin A:Cdk2 complexes by p27/p21
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
Relocalization of nuclearly localized Cyclin D1 to the cytoplasm
Ubiquitination of Cyclin D1
Proteasome mediated degradation of Cyclin D1
Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
CDCA5 (Sororin) enables cohesion of sister chromosomal arms
CDCA5 (Sororin) enables cohesion of sister centromeres
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)
Formation of Cyclin A:Cdc2 complexes
Myt-1 mediated phosphorylation of Cyclin A:Cdc2
Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
Translocation of active Cdc25C to the nucleus
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes
Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes
Formation of Cyclin B:Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
Translocation of Cdc25B to the cytoplasm
Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases
Phosphorylation of Cyclin B1 in the CRS domain
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
Translocation of Cdc25 to the nucleus
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes
Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25
Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes
PLK1 phosphorylates OPTN
Phosphorylated OPTN translocates to the nucleus
Cytosolic PLK1 translocates to the nucleus
Myosin phosphatase dephosphorylates PLK1
Inactivation of Wee1 kinase
Activation of Cdc25C
Inactivation of Myt1 kinase
Recruitment of CDK11p58 to the centrosomes
Recruitment of Plk1 to centrosomes
Cyclin B/Cdk1 mediate phosphorylation of NuMA
Translocation of NuMA to the centrosomes
Association of NuMA with microtubules
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Plk1-mediated phosphorylation of Nlp
Dissociation of Phospho-Nlp from the centrosome
Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi
Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65)
Activation of the Anaphase Promoting Complex (APC) by PLK1
PLK1 phosphorylates GORASP1
MAPK3-3 or MAPK1 phosphorylate GORASP2
GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking
CDK1 phosphorylates MASTL
MASTL (GWL) phosphorylates ARPP19
MASTL phosphorylates ENSA
p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
CDK1:CCNB phosphorylates NEK9
PLK1 phosphorylates NEK9
NEK9 binds NEK6/NEK7 in the cytosol
NEK9 phosphorylates NEK6/NEK7
CDK1 phosphorylates NUP98
NEK6/NEK7 phosphorylates NUP98
VRK1/VRK2 phosphorylate BANF1
Kinetochore capture of astral microtubules
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
Phosphorylation of cohesin by PLK1 at chromosomal arms
Resolution of sister chromatids
Deacetylation of cohesin
Kinetochore assembly
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
CK2 phosphorylates condensin I subunits
Dephosphorylation of CK2-modified condensin I
CDK1 phosphorylates condensin I
Phosphorylated condensin I promotes condensation of prometaphase chromosomes
Down Regulation of Emi1 through Phosphorylation of Emi1
Association of Securin with Cdc20:APC/C complex
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Degradation of multiubiquitinated Securin
PTTG1 (Securin) sequesters ESPL1 (Separase)
Securin sequesters Separase
Autocleavage of ESPL1 (Separase)
Autocleavage of Separin
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
Deacetylation of cleaved cohesin
ANKLE2 binds VRK1 or VRK2
PP2A dephosphorylates BANF1
BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins
Regulation of KIF23 (MKLP1) by phosphorylation
Regulation of KIF20A (MKL2) by phosphorylation
Regulation of NUDC by phosphorylation
Cohesin binds PDS5 and WAPAL
Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2
Association of Cyclin A:Cdk2 with Cdh1
Phosphorylation of Cdh1 by Cyclin A:Cdk2
Dissociation of phospho-Cdh1 from the APC/C complex
Association of Emi1 with Cdh1
Association of Emi1 with Cdc20
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
Phosphorylation of the Emi1 DSGxxS degron by Plk1
Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
Ubiquitination of Emi1 by SCF-beta-TrCP
SCF-mediated degradation of Emi1
Phosphorylation of Cdh1 by Cyclin B1:Cdc2
Free APC/C phosphorylated by Plk1
Free APC/C phosphorylated by Cyclin B:Cdc2
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Degradation of multiubiquitinated Cyclin B
Dephosphorylation of phospho-Cdh1
Dissociation of Cdc20 from APC/C complex
Association of Cdh1 with the APC/C
Association of cell cycle proteins with the APC/C:Cdh1 complex
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Degradation of multiubiquitinated cell cycle proteins
APC/C:Cdh1-mediated degradation of Skp2
Multiubiquitination of APC/C-associated Cdh1
Degradation of multiubiquitinated Cdh1
Mis18 Complex Binds the Centromere.
HJURP:CENPA Complex Localizes to the Centromere.
Deposition of New CENPA-containing Nucleosomes at the Centromere.
RSF Complex Binds the Centromere.
Biogenesis And Assembly Of The Telomerase RNP
TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP
Recruitment of Telomerase RNP to the Telomeric Chromosome End
Alignment Of The RNA Template On The Telomeric Chromosome End
Elongation Of The Telomeric Chromosome End
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End
Elongation of Extended Telomeric Chromosome End
Disassociation of Telomerase RNP and the Chromosome End
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
RFC binding displaces Pol Alpha on the C-strand of the telomere
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
RFC dissociates after sliding clamp formation on the C-strand of the telomere
Formation of Processive Complex on the C-strand of the telomere
Formation of C-strand Okazaki fragments
Formation of the Flap Intermediate on the C-strand
RPA binds to the Flap on the C-strand
Recruitment of Dna2 endonuclease to the C strand
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
Removal of remaining Flap from the C-strand
Joining of adjacent Okazaki fragments of the C-strand
Disassociation of Processive Complex and Completed Telomere End
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure
Formation of Axial/Lateral Elements of Synaptonemal Complex
Formation of the telomere bouquet
Telomere clustering at the nuclear membrane
Formation of Central Elements of the Synaptonemal Complex
Synapsis
Recruitment of BRCA1 to Unsynapsed Regions
Recruitment of ATR Kinase to Unsynapsed Regions
ATR Phosphorylates Histone H2A.X at Unsynapsed Regions
DNA polymerase alpha:primase binds at the origin
DNA polymerase epsilon binds at the origin
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
Orc1 is phosphorylated by cyclin A/CDK2
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
Ubiquitinated Orc1 enters the cytosol
Ubiquitinated Orc1 is degraded by the proteasome
Cdc6 protein is phosphorylated by CDK
Phosphorylated Cdc6 is exported from the nucleus
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
Ubiquitinated Cdc6 is degraded by the proteasome
Mcm4,6,7 trimer forms and associates with the replication fork
Rearrangement and mobilization of Mcm2-7
MCM2-7 mediated fork unwinding
MCM8 mediated fork unwinding
Formation of GINS complex
Multiple proteins are localized at replication fork
RFC binding displaces Pol Alpha
Loading of PCNA - Sliding Clamp Formation
Orc3 associates with Orc2 constitutively bound at origins of replication
RFC dissociates after sliding clamp formation
Formation of Processive Complex
Processive synthesis on the leading strand
Formation of Okazaki fragments
Formation of the Flap Intermediate
RPA binds to the Flap
Recruitment of Dna2 endonuclease
Removal of RNA primer and dissociation of RPA and Dna2
Removal of remaining Flap
Joining of adjacent Okazaki fragments
Orc5 associates with Orc3:Orc2:origin complexes
Cdt1 associates with geminin
Orc4 associates with Orc5:Orc3:Orc2:origin complexes
Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes
Association of MCM8 with ORC:origin complex
DNA replication initiation
Switching of origins to a post-replicative state
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
DNA strand elongation
Unwinding of DNA
Leading Strand Synthesis
Polymerase switching
Lagging Strand Synthesis
Processive synthesis on the lagging strand
M/G1 Transition
Removal of the Flap Intermediate
Regulation of DNA replication
Association of licensing factors with the pre-replicative complex
Removal of licensing factors from origins
DNA Replication Pre-Initiation
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
G1/S DNA Damage Checkpoints
p53-Dependent G1/S DNA damage checkpoint
p53-Dependent G1 DNA Damage Response
Stabilization of p53
Autodegradation of the E3 ubiquitin ligase COP1
Transcriptional activation of p53 responsive genes
Transcriptional activation of cell cycle inhibitor p21
p53-Independent G1/S DNA damage checkpoint
p53-Independent DNA Damage Response
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
G2/M Checkpoints
G2/M DNA damage checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
G2/M DNA replication checkpoint
Activation of ATR in response to replication stress
Mitotic Spindle Checkpoint
Amplification of signal from the kinetochores
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Cell Cycle, Mitotic
Mitotic G1-G1/S phases
G0 and Early G1
G1 Phase
Cyclin D associated events in G1
G1/S Transition
Cyclin E associated events during G1/S transition
SCF(Skp2)-mediated degradation of p27/p21
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Ubiquitin-Dependent Degradation of Cyclin E
G1/S-Specific Transcription
E2F mediated regulation of DNA replication
Inhibition of replication initiation of damaged DNA by RB1/E2F1
E2F-enabled inhibition of pre-replication complex formation
S Phase
Cyclin A:Cdk2-associated events at S phase entry
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D1
Establishment of Sister Chromatid Cohesion
Mitotic G2-G2/M phases
G2 Phase
G2/M Transition
Cyclin A/B1 associated events during G2/M transition
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cyclin B2 mediated events
Regulation of PLK1 Activity at G2/M Transition
Polo-like kinase mediated events
Centrosome maturation
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes
Loss of proteins required for interphase microtubule organizationÂ from the centrosome
Loss of Nlp from mitotic centrosomes
M Phase
Mitotic Prophase
Golgi Cisternae Pericentriolar Stack Reorganization
MASTL Facilitates Mitotic Progression
Nuclear Envelope Breakdown
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Clearance of Nuclear Envelope Membranes from Chromatin
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Mitotic Metaphase and Anaphase
Mitotic Metaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Anaphase
Separation of Sister Chromatids
Nuclear Envelope Reassembly
Initiation of Nuclear Envelope Reformation
Mitotic Telophase/Cytokinesis
cell division
Cohesin Loading onto Chromatin
Regulation of mitotic cell cycle
APC/C-mediated degradation of cell cycle proteins
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
SCF-beta-TrCP mediated degradation of Emi1
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC/C:Cdc20 mediated degradation of mitotic proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Assembly of the ORC complex at the origin of replication
APC/C:Cdc20 mediated degradation of Securin
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Autodegradation of Cdh1 by Cdh1:APC/C
Chromosome Maintenance
Nucleosome assembly
Deposition of New CENPA-containing Nucleosomes at the Centromere
Maintenance of Telomeres
Telomere Maintenance
Extension of Telomeres
Telomere Extension By Telomerase
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Removal of the Flap Intermediate from the C-strand
Packaging Of Telomere Ends
Meiotic Synapsis
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Activation of the pre-replicative complex
Synthesis of DNA
CDC6 protein is synthesized under the control of E2F transcription factors
Transcriptional activation of p21 by p53 after DNA damage
Activation of Cdc25A by c-myc
Activation of E2F target genes at G1/S