@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (29)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

obo:UniProtKB_P23588
	rdfs:label "EIF4B"@em ,
		   "UniProt:P23588 EIF4B"@em .

obo:UniProtKB_Q15056
	rdfs:label "EIF4H"@em ,
		   "KIAA0038"@em ,
		   "UniProt:Q15056 EIF4H"@em ,
		   "WBSCR1"@em ,
		   "WSCR1"@em .

biopax:BiochemicalReaction582
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway194 ;
	obo:directly_activates biopax:BiochemicalReaction583 ,
			       biopax:BiochemicalReaction597 ;
	rdfs:label "Release of 40S and 60S subunits from the 80S ribosome"@em .

biopax:BiochemicalReaction583
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway194 ;
	obo:directly_activates biopax:Pathway195 ;
	rdfs:label "eIF3 and eIF1A bind to the 40S subunit"@em .

biopax:BiochemicalReaction584
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway195 ;
	obo:directly_activates biopax:BiochemicalReaction585 ,
			       biopax:Control44 ;
	rdfs:label "De novo formation of eIF2:GTP"@em .

biopax:BiochemicalReaction585
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway195 ;
	obo:directly_activates biopax:BiochemicalReaction586 ;
	rdfs:label "Met-tRNAi binds to eIF2:GTP to form the ternary complex"@em .

biopax:BiochemicalReaction586
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway195 ;
	rdfs:label "Formation of the 43S pre-initiation complex"@em .

biopax:BiochemicalReaction587
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway196 ;
	obo:directly_activates biopax:BiochemicalReaction588 ;
	rdfs:label "Release of eIF4E from the inactive eIF4E:4E-BP complex"@em .

biopax:BiochemicalReaction588
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway196 ;
	obo:directly_activates biopax:BiochemicalReaction589 ;
	rdfs:label "Formation of the cap-binding eIF4F complex"@em .

biopax:BiochemicalReaction589
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway196 ;
	obo:directly_activates biopax:BiochemicalReaction590 ,
			       biopax:Catalysis212 ,
			       biopax:Catalysis213 ,
			       biopax:Catalysis214 ;
	rdfs:label "eIF4F binds to mRNP"@em .

biopax:BiochemicalReaction590
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0003724 ,
	  obo:GO_0004386 ;
	obo:BFO_0000050 biopax:Pathway196 ;
	obo:directly_activates biopax:BiochemicalReaction591 ,
			       biopax:BiochemicalReaction592 ,
			       biopax:Pathway197 ;
	rdfs:label "Cap-bound mRNA is activated by helicases"@em .

biopax:BiochemicalReaction591
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway197 ;
	rdfs:label "Formation of translation initiation complexes containing mRNA that does not circularize"@em .

biopax:BiochemicalReaction592
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway197 ;
	obo:directly_activates biopax:Pathway88 ;
	rdfs:label "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation"@em .

biopax:BiochemicalReaction593
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0003743 ;
	obo:BFO_0000050 biopax:Pathway198 ;
	obo:directly_activates biopax:BiochemicalReaction594 ,
			       biopax:Catalysis216 ;
	rdfs:label "Ribosomal scanning"@em .

biopax:BiochemicalReaction594
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0003743 ;
	obo:BFO_0000050 biopax:Pathway198 ;
	obo:directly_activates biopax:BiochemicalReaction595 ,
			       biopax:Control46 ;
	rdfs:label "Start codon recognition"@em .

biopax:BiochemicalReaction595
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway199 ;
	obo:directly_activates biopax:BiochemicalReaction597 ,
			       biopax:BiochemicalReaction598 ;
	rdfs:label "eIF2:GTP is hydrolyzed, eIFs are released"@em .

biopax:BiochemicalReaction596
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway199 ;
	obo:directly_activates biopax:BiochemicalReaction607 ;
	rdfs:label "eIF5B:GTP is hydrolyzed and released"@em .

biopax:BiochemicalReaction597
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway199 ;
	obo:directly_activates biopax:BiochemicalReaction596 ;
	rdfs:label "The 60S subunit joins the translation initiation complex"@em .

biopax:BiochemicalReaction598
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway200 ;
	obo:directly_activates biopax:BiochemicalReaction599 ,
			       biopax:Catalysis217 ;
	rdfs:label "Formation of eIF2:GDP:eIF2B intermediate"@em .

biopax:BiochemicalReaction599
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005829
	  ] ,
	  obo:GO_0003743 ;
	obo:BFO_0000050 biopax:Pathway200 ;
	obo:directly_activates biopax:BiochemicalReaction585 ,
			       biopax:Control44 ;
	rdfs:label "eIF2 activation"@em .

biopax:Pathway193
	a obo:GO_0008150 ;
	rdfs:label "Cap-dependent Translation Initiation"@em .

biopax:Pathway194
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "Formation of a pool of free 40S subunits"@em .

biopax:Pathway195
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "Formation of the ternary complex, and subsequently, the 43S complex"@em .

biopax:Pathway196
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"@em .

biopax:Pathway197
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway196 ;
	rdfs:label "Translation initiation complex formation"@em .

biopax:Pathway198
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "Ribosomal scanning and start codon recognition"@em .

biopax:Pathway199
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "GTP hydrolysis and joining of the 60S ribosomal subunit"@em .

biopax:Pathway200
	a obo:GO_0008150 ;
	obo:BFO_0000050 biopax:Pathway193 ;
	rdfs:label "Recycling of eIF2:GDP"@em .