ERK2
label: MAPK1
label: PRKM1
label: PRKM2
label: UniProt:P28482 MAPK1

Adenylate cyclase produces cAMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008294
BFO_0000050: PKA activation
directly activates: cAMP induces dissociation of inactive PKA tetramers
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: BiochemicalReaction4409
directly activates: Catalysis1906
directly activates: Catalysis457
directly activates: Control92
directly activates: Control93

cAMP induces dissociation of inactive PKA tetramers
type: GO_0003674
BFO_0000050: PKA activation
directly activates: PKA catalytic subunit translocates to the nucleus
directly activates: BiochemicalReaction1772
directly activates: BiochemicalReaction4565
directly activates: BiochemicalReaction4724
directly activates: BiochemicalReaction5354
directly activates: Catalysis1982
directly activates: Catalysis2086
directly activates: Catalysis2578
directly activates: Catalysis748
directly activates: Control369
directly activates: Control433

PKA catalytic subunit translocates to the nucleus
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: PKA phosphorylates CREB
directly activates: BiochemicalReaction5352
directly activates: Catalysis2577
directly activates: Catalysis454
directly activates: Control432

PKA phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: PKA-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB

Dimerisation of CREB
type: GO_0003674
BFO_0000050: PKA-mediated phosphorylation of CREB
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

Calmodulin binds CaMK IV
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CamKIV enters the nucleus

CamKIV enters the nucleus
type: GO_0003674
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: CaMK IV autophosphorylation
directly activates: Catalysis455

CaMK IV autophosphorylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB

CaMK IV phosphorylates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004683
BFO_0000050: CaMK IV-mediated phosphorylation of CREB
directly activates: Dimerisation of CREB
directly activates: TemplateReaction23
directly activates: TemplateReactionRegulation31
directly activates: TemplateReactionRegulation32
directly activates: TemplateReactionRegulation33
directly activates: TemplateReactionRegulation34
directly activates: TemplateReactionRegulation35

Calmodulin activates Cam-PDE 1
type: GO_0003674
BFO_0000050: Cam-PDE 1 activation
directly activates: cAMP hydrolysis by Cam-PDE 1
directly activates: Catalysis457

cAMP hydrolysis by Cam-PDE 1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004117
BFO_0000050: Cam-PDE 1 activation

Inhibition of GRK2 by calmodulin
type: GO_0003674
BFO_0000050: Calmodulin induced events

PKC phosphorylates GRK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004672
BFO_0000050: Calmodulin induced events

Calcium binds calmodulin
type: GO_0003674
BFO_0000050: CaM pathway
directly activates: Adenylate cyclase produces cAMP
directly activates: Calmodulin binds CaMK IV
directly activates: Calmodulin activates Cam-PDE 1
directly activates: Inhibition of GRK2 by calmodulin
directly activates: BiochemicalReaction1324
directly activates: BiochemicalReaction243
directly activates: BiochemicalReaction4415
directly activates: BiochemicalReaction5368
directly activates: Catalysis453
directly activates: Control94
directly activates: Control95
directly activates: Modulation7
directly activates: Modulation8
directly activates: CaMK IV-mediated phosphorylation of CREB

Phosphorylation of cPLA2 by ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ERK2
type: Restriction
  on property: enabled by
  some values from: ERK2
type: GO_0016301
BFO_0000050: phospho-PLA2 pathway
directly activates: Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase

Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
type: GO_0003674
BFO_0000050: phospho-PLA2 pathway
directly activates: Hydrolysis of phosphatidylcholine
directly activates: Catalysis1901

Hydrolysis of phosphatidylcholine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047498
BFO_0000050: phospho-PLA2 pathway
directly activates: BiochemicalReaction5188
directly activates: BiochemicalReaction5192
directly activates: BiochemicalReaction5193
directly activates: BiochemicalReaction5258
directly activates: BiochemicalReaction5259
directly activates: BiochemicalReaction5260
directly activates: Catalysis2453
directly activates: Catalysis2454
directly activates: Catalysis2506
directly activates: Catalysis2507
directly activates: Catalysis2508

Ca-dependent events
type: GO_0008150

phospho-PLA2 pathway
type: GO_0008150
BFO_0000050: Ca-dependent events

CaM pathway
type: GO_0008150
BFO_0000050: Ca-dependent events

Calmodulin induced events
type: GO_0008150
BFO_0000050: CaM pathway

PKA-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

PKA activation
type: GO_0008150
BFO_0000050: PKA-mediated phosphorylation of CREB

CaMK IV-mediated phosphorylation of CREB
type: GO_0008150
BFO_0000050: Calmodulin induced events

Cam-PDE 1 activation
type: GO_0008150
BFO_0000050: Calmodulin induced events