@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (10)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction2590
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2591 ;
	rdfs:label "Binding of gp120 of ENV oligomer to the host CD4"@em .

biopax:BiochemicalReaction2591
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2592 ;
	rdfs:label "Conformational change in gp120 of Env oligomer"@em .

biopax:BiochemicalReaction2592
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2593 ;
	rdfs:label "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4"@em .

biopax:BiochemicalReaction2593
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2594 ;
	rdfs:label "Conformational changes in gp120 exposes gp41"@em .

biopax:BiochemicalReaction2594
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2595 ;
	rdfs:label "Fusogenic activation of gp41"@em ,
		   "gp41 N terminal fusion peptide released from viral membrane"@em .

biopax:BiochemicalReaction2595
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2596 ;
	rdfs:label "Insertion of gp41 fusion peptide into the target membrane"@em .

biopax:BiochemicalReaction2596
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2597 ;
	rdfs:label "N and C terminal heptad repeat helices of gp41 form six-helix bundle"@em .

biopax:BiochemicalReaction2597
	a obo:GO_0019064 ;
	obo:BFO_0000050 biopax:Pathway592 ;
	obo:directly_activates biopax:BiochemicalReaction2598 ;
	rdfs:label "Fusion of viral membrane with host cell membrane"@em .

biopax:Pathway592
	a obo:GO_0008150 ;
	rdfs:label "Binding and entry of HIV virion"@em .