CDC6 association with ORC:origin complexes mediated by MCM8
type: GO_0003674
BFO_0000050: CDC6 association with the ORC:origin complex
directly activates: Free CDT1 associates with CDC6:ORC:origin complexes

The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
type: GO_0003674
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex
directly activates: Ubiquitinated geminin is degraded by the proteasome
directly activates: Free CDT1 associates with CDC6:ORC:origin complexes
directly activates: Catalysis3

Ubiquitinated geminin is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex

Free CDT1 associates with CDC6:ORC:origin complexes
type: GO_0003674
BFO_0000050: CDT1 association with the CDC6:ORC:origin complex

Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)
type: GO_0003674
BFO_0000050: Assembly of the pre-replicative complex
directly activates: BiochemicalReaction15
directly activates: BiochemicalReaction34
directly activates: BiochemicalReaction35
directly activates: Catalysis12
directly activates: Catalysis13

Orc3 associates with Orc2 constitutively bound at origins of replication
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc5 associates with Orc3:Orc2:origin complexes

Orc5 associates with Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc4 associates with Orc5:Orc3:Orc2:origin complexes

Orc4 associates with Orc5:Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes

Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes

Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes
type: GO_0003674
BFO_0000050: Assembly of the ORC complex at the origin of replication
directly activates: BiochemicalReaction1910

Association of MCM8 with ORC:origin complex
type: GO_0003674
BFO_0000050: Assembly of the pre-replicative complex
directly activates: CDC6 association with ORC:origin complexes mediated by MCM8
directly activates: CDC6 association with the ORC:origin complex

Assembly of the pre-replicative complex
type: GO_0008150

Assembly of the ORC complex at the origin of replication
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

CDC6 association with the ORC:origin complex
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

CDT1 association with the CDC6:ORC:origin complex
type: GO_0008150
BFO_0000050: Assembly of the pre-replicative complex

CDC6 protein is synthesized under the control of E2F transcription factors
type: GO_0003674
BFO_0000050: CDC6 association with the ORC:origin complex
directly activates: CDC6 association with ORC:origin complexes mediated by MCM8