CYP17
CYP17A1
S17AH
UniProt:P05093 CYP17A1
EDH17B3
HSD17B3
UniProt:P37058 HSD17B3
Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA
DHA isomerizes to 4-Androstene3,17-dione
Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone
progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione
Reduction of androstenedione to testosterone
Testosterone is converted to 5-alpha-dihydroxytestosterone
Androgen biosynthesis