CYP17
label: CYP17A1
label: S17AH
label: UniProt:P05093 CYP17A1

EDH17B3
label: HSD17B3
label: UniProt:P37058 HSD17B3

Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Androgen biosynthesis
directly activates: BiochemicalReaction2559
directly activates: 17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
directly activates: Catalysis1103
directly activates: Catalysis1114
directly activates: Control175
label: pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O

17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP17
type: GO_0004508
BFO_0000050: Androgen biosynthesis
directly activates: DHA isomerizes to 4-Androstene3,17-dione
directly activates: Catalysis1115
directly activates: Control176
label: Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA

DHA isomerizes to 4-Androstene3,17-dione
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004769
BFO_0000050: Androgen biosynthesis
directly activates: Reduction of androstenedione to testosterone
directly activates: Catalysis1118
directly activates: Control177
directly activates: Control178

Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004508
BFO_0000050: Androgen biosynthesis
directly activates: 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
directly activates: Catalysis1117
label: progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O

17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
type: Restriction
  on property: enabled by
  some values from: CYP17
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004508
BFO_0000050: Androgen biosynthesis
directly activates: Reduction of androstenedione to testosterone
directly activates: BiochemicalReaction2580
directly activates: Catalysis1118
directly activates: Catalysis1121
directly activates: Control177
directly activates: Control178
label: Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione

Reduction of androstenedione to testosterone
type: Restriction
  on property: enabled by
  some values from: EDH17B3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0050327
BFO_0000050: Androgen biosynthesis
directly activates: Testosterone is converted to 5-alpha-dihydroxytestosterone
directly activates: BiochemicalReaction2579
directly activates: Catalysis1119
directly activates: Catalysis1120
directly activates: Control179

Testosterone is converted to 5-alpha-dihydroxytestosterone
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003865
BFO_0000050: Androgen biosynthesis

Androgen biosynthesis
type: GO_0008150