@prefix    owl: <http://www.w3.org/2002/07/owl#> .
@prefix   rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix    rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biopax: <http://www.reactome.org/biopax/48887#> .
@prefix    obo: <http://purl.obolibrary.org/obo/> .

# Named toplevel resources (10)

<http://example.org>
	a owl:Ontology ;
	owl:imports <http://purl.obolibrary.org/obo/go.owl> ,
		    <http://purl.obolibrary.org/obo/go/extensions/lego-relations.owl> .

biopax:BiochemicalReaction15
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction16 ,
			       biopax:BiochemicalReaction17 ;
	rdfs:label "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7"@em .

biopax:BiochemicalReaction16
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction50 ;
	rdfs:label "Cdt1 is displaced from the pre-replicative complex."@em .

biopax:BiochemicalReaction17
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction18 ,
			       biopax:BiochemicalReaction19 ,
			       biopax:Catalysis4 ;
	rdfs:label "CDK and DDK associate with the Mcm10:pre-replicative complex"@em .

biopax:BiochemicalReaction18
	a [ a owl:Restriction ;
	    owl:onProperty obo:BFO_0000066 ;
	    owl:someValuesFrom obo:GO_0005654
	  ] ,
	  obo:GO_0016301 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	rdfs:label "Mcm2-7 is phosphorylated by DDK"@em .

biopax:BiochemicalReaction19
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction20 ;
	rdfs:label "Cdc45 associates with the pre-replicative complex at the origin"@em .

biopax:BiochemicalReaction20
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction21 ,
			       biopax:BiochemicalReaction22 ,
			       biopax:Control1 ,
			       biopax:Control2 ;
	rdfs:label "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin"@em .

biopax:BiochemicalReaction21
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	obo:directly_activates biopax:BiochemicalReaction23 ,
			       biopax:Catalysis5 ;
	rdfs:label "DNA polymerase alpha:primase binds at the origin"@em .

biopax:BiochemicalReaction22
	a obo:GO_0003674 ;
	obo:BFO_0000050 biopax:Pathway8 ;
	rdfs:label "DNA polymerase epsilon binds at the origin"@em .

biopax:Pathway8
	a obo:GO_0008150 ;
	rdfs:label "Activation of the pre-replicative complex"@em .