Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Cdt1 is displaced from the pre-replicative complex.
directly activates: CDK and DDK associate with the Mcm10:pre-replicative complex

Cdt1 is displaced from the pre-replicative complex.
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: BiochemicalReaction50

CDK and DDK associate with the Mcm10:pre-replicative complex
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: Mcm2-7 is phosphorylated by DDK
directly activates: Cdc45 associates with the pre-replicative complex at the origin
directly activates: Catalysis4

Mcm2-7 is phosphorylated by DDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Activation of the pre-replicative complex

Cdc45 associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin

DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: DNA polymerase alpha:primase binds at the origin
directly activates: DNA polymerase epsilon binds at the origin
directly activates: Control1
directly activates: Control2

DNA polymerase alpha:primase binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex
directly activates: BiochemicalReaction23
directly activates: Catalysis5

DNA polymerase epsilon binds at the origin
type: GO_0003674
BFO_0000050: Activation of the pre-replicative complex

Activation of the pre-replicative complex
type: GO_0008150