format-version: 1.2 subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_yeast "Yeast GO slim" synonymtypedef: syngo_official_label "label approved by the SynGO project" synonymtypedef: systematic_synonym "Systematic synonym" EXACT ontology: go/subsets/goslim_metagenomics [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics synonym: "enolase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: goslim_metagenomics synonym: "strand transferase" NARROW [] xref: Reactome:REACT_27300 "Formation of Meiotic Heteroduplex, Homo sapiens" is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0006259 ! DNA metabolic process [Term] id: GO:0000160 name: phosphorelay signal transduction system namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: goslim_metagenomics synonym: "histidyl-aspartyl phosphorelay" EXACT [] synonym: "phosphorelay signal transduction system" NARROW [] is_a: GO:0007165 ! signal transduction relationship: occurs_in GO:0005622 ! intracellular [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0003674 ! molecular_function [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0003674 ! molecular_function [Term] id: GO:0003700 name: DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 alt_id: GO:0001071 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Changed definition see https://github.com/geneontology/go-ontology/issues/15704 subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "DNA binding transcription factor activity" EXACT [] synonym: "gene-specific transcription factor activity" EXACT [] synonym: "nucleic acid binding transcription factor activity" BROAD [] synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0019222 ! regulation of metabolic process created_by: kchris creation_date: 2010-10-21T04:37:54Z [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: goslim_metagenomics synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: KEGG:R03532 xref: MetaCyc:PEROXID-RXN xref: Reactome:REACT_100373 "Peroxidative reduction of PGG2 to PGH2, Bos taurus" xref: Reactome:REACT_101046 "DIT and MIT combine to form triiodothyronine, Sus scrofa" xref: Reactome:REACT_101589 "Tyrosine is diiodinated, Rattus norvegicus" xref: Reactome:REACT_102144 "Peroxidative reduction of PGG2 to PGH2, Taeniopygia guttata" xref: Reactome:REACT_104442 "Tyrosine is diiodinated, Canis familiaris" xref: Reactome:REACT_105725 "Peroxidative reduction of PGG2 to PGH2, Mus musculus" xref: Reactome:REACT_106670 "Tyrosine is diiodinated, Mus musculus" xref: Reactome:REACT_108020 "Iodide is organified, Rattus norvegicus" xref: Reactome:REACT_108229 "Peroxidative reduction of PGG2 to PGH2, Gallus gallus" xref: Reactome:REACT_111983 "Tyrosine is monoiodinated, Dictyostelium discoideum" xref: Reactome:REACT_112213 "Iodide is organified, Danio rerio" xref: Reactome:REACT_112249 "Tyrosine is diiodinated, Dictyostelium discoideum" xref: Reactome:REACT_113235 "Tyrosine is diiodinated, Danio rerio" xref: Reactome:REACT_113904 "DIT and MIT combine to form triiodothyronine, Dictyostelium discoideum" xref: Reactome:REACT_113988 "Two DITs combine to form thyroxine, Dictyostelium discoideum" xref: Reactome:REACT_114100 "Iodide is organified, Dictyostelium discoideum" xref: Reactome:REACT_114351 "Tyrosine is monoiodinated, Danio rerio" xref: Reactome:REACT_114796 "DIT and MIT combine to form triiodothyronine, Danio rerio" xref: Reactome:REACT_115058 "Two DITs combine to form thyroxine, Danio rerio" xref: Reactome:REACT_15360 "DIT and MIT combine to form triiodothyronine, Homo sapiens" xref: Reactome:REACT_15430 "Two DITs combine to form thyroxine, Homo sapiens" xref: Reactome:REACT_15445 "Tyrosine is monoiodinated, Homo sapiens" xref: Reactome:REACT_15455 "Tyrosine is diiodinated, Homo sapiens" xref: Reactome:REACT_15539 "Iodide is organified, Homo sapiens" xref: Reactome:REACT_28086 "Tyrosine is monoiodinated, Canis familiaris" xref: Reactome:REACT_28372 "Two DITs combine to form thyroxine, Taeniopygia guttata" xref: Reactome:REACT_29881 "Peroxidative reduction of PGG2 to PGH2, Canis familiaris" xref: Reactome:REACT_30736 "Two DITs combine to form thyroxine, Rattus norvegicus" xref: Reactome:REACT_30826 "DIT and MIT combine to form triiodothyronine, Rattus norvegicus" xref: Reactome:REACT_31807 "Peroxidative reduction of PGG2 to PGH2, Sus scrofa" xref: Reactome:REACT_32140 "Peroxidative reduction of PGG2 to PGH2, Xenopus tropicalis" xref: Reactome:REACT_32854 "Peroxidative reduction of PGG2 to PGH2, Danio rerio" xref: Reactome:REACT_33827 "Two DITs combine to form thyroxine, Sus scrofa" xref: Reactome:REACT_33837 "Tyrosine is monoiodinated, Taeniopygia guttata" xref: Reactome:REACT_76985 "Iodide is organified, Mus musculus" xref: Reactome:REACT_78273 "DIT and MIT combine to form triiodothyronine, Xenopus tropicalis" xref: Reactome:REACT_78937 "Iodide is organified, Gallus gallus" xref: Reactome:REACT_79084 "Tyrosine is diiodinated, Xenopus tropicalis" xref: Reactome:REACT_79114 "DIT and MIT combine to form triiodothyronine, Canis familiaris" xref: Reactome:REACT_810 "Peroxidative reduction of PGG2 to PGH2, Homo sapiens" xref: Reactome:REACT_81922 "Two DITs combine to form thyroxine, Canis familiaris" xref: Reactome:REACT_82000 "Tyrosine is monoiodinated, Rattus norvegicus" xref: Reactome:REACT_85332 "Two DITs combine to form thyroxine, Mus musculus" xref: Reactome:REACT_85339 "Iodide is organified, Xenopus tropicalis" xref: Reactome:REACT_85899 "Tyrosine is diiodinated, Taeniopygia guttata" xref: Reactome:REACT_86613 "Tyrosine is monoiodinated, Mus musculus" xref: Reactome:REACT_87489 "Iodide is organified, Canis familiaris" xref: Reactome:REACT_87731 "Tyrosine is diiodinated, Gallus gallus" xref: Reactome:REACT_88313 "Iodide is organified, Taeniopygia guttata" xref: Reactome:REACT_90277 "Two DITs combine to form thyroxine, Gallus gallus" xref: Reactome:REACT_90987 "Tyrosine is diiodinated, Sus scrofa" xref: Reactome:REACT_91636 "Tyrosine is monoiodinated, Gallus gallus" xref: Reactome:REACT_91853 "Tyrosine is monoiodinated, Xenopus tropicalis" xref: Reactome:REACT_92128 "DIT and MIT combine to form triiodothyronine, Mus musculus" xref: Reactome:REACT_94963 "Tyrosine is monoiodinated, Sus scrofa" xref: Reactome:REACT_96008 "DIT and MIT combine to form triiodothyronine, Taeniopygia guttata" xref: Reactome:REACT_97146 "Iodide is organified, Sus scrofa" xref: Reactome:REACT_97248 "Two DITs combine to form thyroxine, Xenopus tropicalis" xref: Reactome:REACT_97539 "Peroxidative reduction of PGG2 to PGH2, Rattus norvegicus" xref: Reactome:REACT_98848 "DIT and MIT combine to form triiodothyronine, Gallus gallus" xref: RHEA:23637 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004803 name: transposase activity namespace: molecular_function alt_id: GO:0004804 def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "P-element encoded transposase activity" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "carrier" RELATED [] xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: Reactome:REACT_100287 "Formation of the IGF:IGFBP-4 Complex, Canis familiaris" xref: Reactome:REACT_101129 "Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_102084 "Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus" xref: Reactome:REACT_102457 "An anchoring protein, SARA, recruits SMAD2/3, Canis familiaris" xref: Reactome:REACT_103972 "Type II receptor recruits type I receptor, Xenopus tropicalis" xref: Reactome:REACT_104029 "Formation of the IGF:IGFBP-6 Complex, Bos taurus" xref: Reactome:REACT_104599 "Type II receptor recruits type I receptor, Sus scrofa" xref: Reactome:REACT_105776 "Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio" xref: Reactome:REACT_105895 "Formation of the IGF:IGFBP-4 Complex, Bos taurus" xref: Reactome:REACT_106168 "Formation of the IGF:IGFBP-2 Complex, Bos taurus" xref: Reactome:REACT_106189 "Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus" xref: Reactome:REACT_107402 "Formation of the IGF:IGFBP-4 Complex, Mus musculus" xref: Reactome:REACT_108283 "Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis" xref: Reactome:REACT_109392 "Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus" xref: Reactome:REACT_110419 "Type II receptor recruits type I receptor, Bos taurus" xref: Reactome:REACT_110570 "Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa" xref: Reactome:REACT_15321 "Formation of the IGF:IGFBP-1 Complex, Homo sapiens" xref: Reactome:REACT_15325 "Formation of the IGF:IGFBP-4 Complex, Homo sapiens" xref: Reactome:REACT_15355 "Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens" xref: Reactome:REACT_15417 "Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens" xref: Reactome:REACT_15419 "Formation of the IGF:IGFBP-2 Complex, Homo sapiens" xref: Reactome:REACT_15506 "Formation of the IGF:IGFBP-6 Complex, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus" xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus" xref: Reactome:REACT_28794 "Formation of the IGF:IGFBP-4 Complex, Sus scrofa" xref: Reactome:REACT_30571 "Formation of the IGF:IGFBP-6 Complex, Danio rerio" xref: Reactome:REACT_30672 "Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata" xref: Reactome:REACT_31305 "Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_31537 "Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus" xref: Reactome:REACT_31641 "Type II receptor recruits type I receptor, Danio rerio" xref: Reactome:REACT_31648 "An anchoring protein, SARA, recruits SMAD2/3, Mus musculus" xref: Reactome:REACT_32973 "Formation of the IGF:IGFBP-1 Complex, Canis familiaris" xref: Reactome:REACT_33135 "An anchoring protein, SARA, recruits SMAD2/3, Rattus norvegicus" xref: Reactome:REACT_34719 "Formation of the IGF:IGFBP-1 Complex, Danio rerio" xref: Reactome:REACT_6923 "An anchoring protein, SARA, recruits SMAD2/3, Homo sapiens" xref: Reactome:REACT_6945 "Type II receptor recruits type I receptor, Homo sapiens" xref: Reactome:REACT_78382 "Formation of the IGF:IGFBP-1 Complex, Mus musculus" xref: Reactome:REACT_78466 "Formation of the IGF:IGFBP-6 Complex, Canis familiaris" xref: Reactome:REACT_79634 "Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris" xref: Reactome:REACT_80470 "Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus" xref: Reactome:REACT_80778 "Type II receptor recruits type I receptor, Mus musculus" xref: Reactome:REACT_83147 "Type II receptor recruits type I receptor, Rattus norvegicus" xref: Reactome:REACT_83165 "Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa" xref: Reactome:REACT_83532 "Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis" xref: Reactome:REACT_85250 "Formation of the IGF:IGFBP-2 Complex, Canis familiaris" xref: Reactome:REACT_85858 "Formation of the IGF:IGFBP-2 Complex, Gallus gallus" xref: Reactome:REACT_85975 "An anchoring protein, SARA, recruits SMAD2/3, Danio rerio" xref: Reactome:REACT_87187 "An anchoring protein, SARA, recruits SMAD2/3, Xenopus tropicalis" xref: Reactome:REACT_87374 "Formation of the IGF:IGFBP-6 Complex, Sus scrofa" xref: Reactome:REACT_87652 "Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus" xref: Reactome:REACT_88068 "Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris" xref: Reactome:REACT_88138 "Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio" xref: Reactome:REACT_88223 "Formation of the IGF:IGFBP-1 Complex, Sus scrofa" xref: Reactome:REACT_89261 "Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata" xref: Reactome:REACT_90027 "Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus" xref: Reactome:REACT_90105 "Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis" xref: Reactome:REACT_90666 "An anchoring protein, SARA, recruits SMAD2/3, Sus scrofa" xref: Reactome:REACT_91560 "Type II receptor recruits type I receptor, Canis familiaris" xref: Reactome:REACT_92029 "Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus" xref: Reactome:REACT_93175 "Formation of the IGF:IGFBP-1 Complex, Gallus gallus" xref: Reactome:REACT_93938 "Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_94522 "Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_94808 "Formation of the IGF:IGFBP-6 Complex, Mus musculus" xref: Reactome:REACT_95241 "Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus" xref: Reactome:REACT_95561 "Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis" xref: Reactome:REACT_95647 "Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus" xref: Reactome:REACT_96236 "Formation of the IGF:IGFBP-2 Complex, Mus musculus" xref: Reactome:REACT_96264 "Formation of the IGF:IGFBP-2 Complex, Danio rerio" xref: Reactome:REACT_98028 "Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata" xref: Reactome:REACT_98807 "An anchoring protein, SARA, recruits SMAD2/3, Bos taurus" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao-1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao-1337158144 xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cell_wall is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005727 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: goslim_metagenomics is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005839 name: proteasome core complex namespace: cellular_component alt_id: GO:0000503 def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] subset: goslim_metagenomics synonym: "20S core complex" NARROW [] synonym: "20S proteasome" NARROW [GOC:cjk] synonym: "macropain" EXACT [] synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular relationship: part_of GO:1902494 ! catalytic complex [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: Reactome:REACT_102834 "Metabolism of carbohydrates, Mus musculus" xref: Reactome:REACT_103806 "Metabolism of carbohydrates, Mycobacterium tuberculosis" xref: Reactome:REACT_104502 "Metabolism of carbohydrates, Gallus gallus" xref: Reactome:REACT_105321 "Metabolism of carbohydrates, Escherichia coli" xref: Reactome:REACT_106046 "Metabolism of carbohydrates, Drosophila melanogaster" xref: Reactome:REACT_107409 "Metabolism of carbohydrates, Caenorhabditis elegans" xref: Reactome:REACT_115733 "Carbohydrate metabolism, Gallus gallus" xref: Reactome:REACT_28218 "Metabolism of carbohydrates, Xenopus tropicalis" xref: Reactome:REACT_32291 "Metabolism of carbohydrates, Staphylococcus aureus N315" xref: Reactome:REACT_33141 "Metabolism of carbohydrates, Taeniopygia guttata" xref: Reactome:REACT_33953 "Metabolism of carbohydrates, Rattus norvegicus" xref: Reactome:REACT_34800 "Metabolism of carbohydrates, Danio rerio" xref: Reactome:REACT_474 "Metabolism of carbohydrates, Homo sapiens" xref: Reactome:REACT_77669 "Metabolism of carbohydrates, Plasmodium falciparum" xref: Reactome:REACT_81945 "Metabolism of carbohydrates, Schizosaccharomyces pombe" xref: Reactome:REACT_83038 "Metabolism of carbohydrates, Arabidopsis thaliana" xref: Reactome:REACT_83329 "Metabolism of carbohydrates, Saccharomyces cerevisiae" xref: Reactome:REACT_88330 "Metabolism of carbohydrates, Bos taurus" xref: Reactome:REACT_88558 "Metabolism of carbohydrates, Canis familiaris" xref: Reactome:REACT_90099 "Metabolism of carbohydrates, Sus scrofa" xref: Reactome:REACT_96375 "Metabolism of carbohydrates, Dictyostelium discoideum" xref: Reactome:REACT_98394 "Metabolism of carbohydrates, Oryza sativa" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0006282 name: regulation of DNA repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0006259 ! DNA metabolic process relationship: regulates GO:0006950 ! response to stress [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: Wikipedia:Transcription_(genetics) is_a: GO:0009058 ! biosynthetic process is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:REACT_100338 "Translation, Sus scrofa" xref: Reactome:REACT_100851 "Translation, Saccharomyces cerevisiae" xref: Reactome:REACT_101045 "Translation, Dictyostelium discoideum" xref: Reactome:REACT_101324 "Translation, Canis familiaris" xref: Reactome:REACT_1014 "Translation, Homo sapiens" xref: Reactome:REACT_103420 "Translation, Plasmodium falciparum" xref: Reactome:REACT_105544 "Translation, Arabidopsis thaliana" xref: Reactome:REACT_29980 "Translation, Bos taurus" xref: Reactome:REACT_33559 "Translation, Rattus norvegicus" xref: Reactome:REACT_77710 "Translation, Drosophila melanogaster" xref: Reactome:REACT_79784 "Translation, Danio rerio" xref: Reactome:REACT_81734 "Translation, Schizosaccharomyces pombe" xref: Reactome:REACT_81833 "Translation, Caenorhabditis elegans" xref: Reactome:REACT_82171 "Translation, Xenopus tropicalis" xref: Reactome:REACT_83429 "Translation, Taeniopygia guttata" xref: Reactome:REACT_83530 "Translation, Gallus gallus" xref: Reactome:REACT_86996 "Translation, Oryza sativa" xref: Reactome:REACT_95535 "Translation, Mus musculus" xref: Reactome:REACT_96394 "Translation, Escherichia coli" xref: Wikipedia:Translation_(genetics) is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0009058 ! biosynthetic process relationship: has_part GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:REACT_100411 "Chaperonin-mediated protein folding, Arabidopsis thaliana" xref: Reactome:REACT_104912 "Chaperonin-mediated protein folding, Caenorhabditis elegans" xref: Reactome:REACT_105663 "Chaperonin-mediated protein folding, Rattus norvegicus" xref: Reactome:REACT_106009 "Chaperonin-mediated protein folding, Canis familiaris" xref: Reactome:REACT_106427 "Chaperonin-mediated protein folding, Mus musculus" xref: Reactome:REACT_106894 "Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris" xref: Reactome:REACT_106927 "Chaperonin-mediated protein folding, Drosophila melanogaster" xref: Reactome:REACT_107029 "Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster" xref: Reactome:REACT_108248 "Chaperonin-mediated protein folding, Gallus gallus" xref: Reactome:REACT_109411 "Formation of tubulin folding intermediates by CCT/TriC, Bos taurus" xref: Reactome:REACT_110417 "Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus" xref: Reactome:REACT_16956 "Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens" xref: Reactome:REACT_17001 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_17004 "Chaperonin-mediated protein folding, Homo sapiens" xref: Reactome:REACT_17056 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus" xref: Reactome:REACT_23878 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens" xref: Reactome:REACT_30906 "Chaperonin-mediated protein folding, Oryza sativa" xref: Reactome:REACT_32155 "Chaperonin-mediated protein folding, Saccharomyces cerevisiae" xref: Reactome:REACT_32255 "Chaperonin-mediated protein folding, Schizosaccharomyces pombe" xref: Reactome:REACT_33395 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_77627 "Chaperonin-mediated protein folding, Plasmodium falciparum" xref: Reactome:REACT_77963 "Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae" xref: Reactome:REACT_78530 "Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus" xref: Reactome:REACT_81155 "Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans" xref: Reactome:REACT_83906 "Chaperonin-mediated protein folding, Dictyostelium discoideum" xref: Reactome:REACT_85492 "Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa" xref: Reactome:REACT_85496 "Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum" xref: Reactome:REACT_86318 "Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana" xref: Reactome:REACT_91676 "Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe" xref: Reactome:REACT_92785 "Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum" xref: Reactome:REACT_92961 "Chaperonin-mediated protein folding, Xenopus tropicalis" xref: Reactome:REACT_92981 "Chaperonin-mediated protein folding, Taeniopygia guttata" xref: Reactome:REACT_94123 "Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata" xref: Reactome:REACT_94443 "Formation of tubulin folding intermediates by CCT/TriC, Danio rerio" xref: Reactome:REACT_94772 "Chaperonin-mediated protein folding, Sus scrofa" xref: Reactome:REACT_96773 "Chaperonin-mediated protein folding, Danio rerio" xref: Reactome:REACT_97016 "Chaperonin-mediated protein folding, Bos taurus" xref: Reactome:REACT_97220 "Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis" xref: Reactome:REACT_98132 "Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa" xref: Wikipedia:Protein_folding is_a: GO:0008150 ! biological_process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Reactome:REACT_105459 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Gallus gallus" xref: Reactome:REACT_106013 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Canis familiaris" xref: Reactome:REACT_106377 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Mus musculus" xref: Reactome:REACT_107219 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Danio rerio" xref: Reactome:REACT_110326 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Bos taurus" xref: Reactome:REACT_733 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Homo sapiens" xref: Reactome:REACT_84556 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Xenopus tropicalis" xref: Reactome:REACT_92566 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Sus scrofa" xref: Reactome:REACT_95969 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Taeniopygia guttata" xref: Reactome:REACT_98959 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Rattus norvegicus" xref: Wikipedia:Proteolysis is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:REACT_104930 "Lipid digestion, mobilization, and transport, Drosophila melanogaster" xref: Reactome:REACT_107479 "Lipid digestion, mobilization, and transport, Xenopus tropicalis" xref: Reactome:REACT_108775 "Lipid digestion, mobilization, and transport, Canis familiaris" xref: Reactome:REACT_114669 "Lipid digestion, mobilization, and transport, Staphylococcus aureus N315" xref: Reactome:REACT_115652 "Lipid metabolism, Gallus gallus" xref: Reactome:REACT_28745 "Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae" xref: Reactome:REACT_31395 "Lipid digestion, mobilization, and transport, Sus scrofa" xref: Reactome:REACT_32539 "Lipid digestion, mobilization, and transport, Bos taurus" xref: Reactome:REACT_33836 "Lipid digestion, mobilization, and transport, Rattus norvegicus" xref: Reactome:REACT_602 "Lipid digestion, mobilization, and transport, Homo sapiens" xref: Reactome:REACT_77176 "Lipid digestion, mobilization, and transport, Danio rerio" xref: Reactome:REACT_77191 "Lipid digestion, mobilization, and transport, Arabidopsis thaliana" xref: Reactome:REACT_79244 "Lipid digestion, mobilization, and transport, Plasmodium falciparum" xref: Reactome:REACT_81778 "Lipid digestion, mobilization, and transport, Oryza sativa" xref: Reactome:REACT_82512 "Lipid digestion, mobilization, and transport, Taeniopygia guttata" xref: Reactome:REACT_82723 "Lipid digestion, mobilization, and transport, Escherichia coli" xref: Reactome:REACT_87884 "Lipid digestion, mobilization, and transport, Caenorhabditis elegans" xref: Reactome:REACT_90757 "Lipid digestion, mobilization, and transport, Mus musculus" xref: Reactome:REACT_94607 "Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis" xref: Reactome:REACT_97906 "Lipid digestion, mobilization, and transport, Gallus gallus" xref: Reactome:REACT_98129 "Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe" xref: Reactome:REACT_99706 "Lipid digestion, mobilization, and transport, Dictyostelium discoideum" xref: Wikipedia:Lipid_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006808 name: regulation of nitrogen utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0008150 ! biological_process created_by: janelomax creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0008150 ! biological_process created_by: davidos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Reactome:REACT_100624 "EGFR interacts with phospholipase C-gamma, Gallus gallus" xref: Reactome:REACT_102354 "EGFR interacts with phospholipase C-gamma, Canis familiaris" xref: Reactome:REACT_112130 "EGFR interacts with phospholipase C-gamma, Oryza sativa" xref: Reactome:REACT_112549 "EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana" xref: Reactome:REACT_113151 "EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis" xref: Reactome:REACT_113601 "EGFR interacts with phospholipase C-gamma, Drosophila melanogaster" xref: Reactome:REACT_113964 "EGFR interacts with phospholipase C-gamma, Bos taurus" xref: Reactome:REACT_114657 "EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum" xref: Reactome:REACT_114690 "EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae" xref: Reactome:REACT_114820 "EGFR interacts with phospholipase C-gamma, Sus scrofa" xref: Reactome:REACT_114910 "EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans" xref: Reactome:REACT_115037 "EGFR interacts with phospholipase C-gamma, Plasmodium falciparum" xref: Reactome:REACT_115147 "EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe" xref: Reactome:REACT_12478 "EGFR interacts with phospholipase C-gamma, Homo sapiens" xref: Reactome:REACT_31232 "EGFR interacts with phospholipase C-gamma, Rattus norvegicus" xref: Reactome:REACT_78535 "EGFR interacts with phospholipase C-gamma, Xenopus tropicalis" xref: Reactome:REACT_89740 "EGFR interacts with phospholipase C-gamma, Taeniopygia guttata" xref: Reactome:REACT_93680 "EGFR interacts with phospholipase C-gamma, Danio rerio" xref: Reactome:REACT_98872 "EGFR interacts with phospholipase C-gamma, Mus musculus" xref: Wikipedia:Signal_transduction is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process created_by: janelomax creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process created_by: janelomax creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Bioluminescence is_a: GO:0008152 ! metabolic process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: Reactome:REACT_106748 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus" xref: Reactome:REACT_110349 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus" xref: Reactome:REACT_13710 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens" xref: Reactome:REACT_19284 "Proteolytic processing of Slit, Homo sapiens" xref: Reactome:REACT_93020 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus" xref: Reactome:REACT_99630 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus" is_a: GO:0016787 ! hydrolase activity relationship: part_of GO:0006508 ! proteolysis [Term] id: GO:0008658 name: penicillin binding namespace: molecular_function def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: goslim_metagenomics is_a: GO:0043167 ! ion binding [Term] id: GO:0009055 name: electron transfer activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transporter activity" RELATED [] xref: Reactome:REACT_100606 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Caenorhabditis elegans" xref: Reactome:REACT_107372 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Xenopus tropicalis" xref: Reactome:REACT_107740 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mus musculus" xref: Reactome:REACT_107845 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Rattus norvegicus" xref: Reactome:REACT_108215 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Saccharomyces cerevisiae" xref: Reactome:REACT_109222 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Danio rerio" xref: Reactome:REACT_28440 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Escherichia coli" xref: Reactome:REACT_29712 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Bos taurus" xref: Reactome:REACT_31774 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Dictyostelium discoideum" xref: Reactome:REACT_6154 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Homo sapiens" xref: Reactome:REACT_78399 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Sus scrofa" xref: Reactome:REACT_81671 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Arabidopsis thaliana" xref: Reactome:REACT_89868 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Taeniopygia guttata" xref: Reactome:REACT_94498 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Drosophila melanogaster" xref: Reactome:REACT_98413 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Canis familiaris" xref: Reactome:REACT_98930 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Schizosaccharomyces pombe" xref: Reactome:REACT_99683 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mycobacterium tuberculosis" xref: Reactome:REACT_99848 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Oryza sativa" is_a: GO:0016491 ! oxidoreductase activity relationship: part_of GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009276 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] subset: goslim_metagenomics synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall inner membrane" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009288 name: bacterial-type flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] subset: goslim_metagenomics subset: goslim_pir synonym: "flagellin-based flagellum" EXACT [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0009317 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] subset: goslim_metagenomics subset: goslim_pir synonym: "ACCase complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009341 name: beta-galactosidase complex namespace: cellular_component def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161] subset: goslim_metagenomics is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009346 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: goslim_metagenomics is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009349 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: goslim_metagenomics is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0009372 name: quorum sensing namespace: biological_process def: "The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518] subset: goslim_metagenomics subset: goslim_pir synonym: "quorum sensing system" EXACT [] xref: Wikipedia:Quorum_sensing is_a: GO:0008150 ! biological_process [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics synonym: "virulence" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0008150 ! biological_process [Term] id: GO:0015238 name: drug transmembrane transporter activity namespace: molecular_function alt_id: GO:0015239 alt_id: GO:0015559 alt_id: GO:0015564 alt_id: GO:0090484 def: "Enables the transfer of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732] subset: goslim_metagenomics synonym: "drug transporter activity" RELATED [] synonym: "multidrug efflux pump activity" RELATED [] synonym: "multidrug transporter activity" RELATED [] synonym: "multidrug, alkane resistant pump activity" RELATED [] is_a: GO:0005215 ! transporter activity relationship: part_of GO:0006810 ! transport relationship: part_of GO:0042221 ! response to chemical created_by: tanyaberardini creation_date: 2012-10-04T15:29:23Z [Term] id: GO:0015948 name: methanogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir synonym: "methane biosynthesis" EXACT [] synonym: "methane biosynthetic process" EXACT [] xref: UM-BBD_pathwayID:meth xref: Wikipedia:Methanogenesis is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant xref: Wikipedia:Photosynthesis is_a: GO:0008152 ! metabolic process [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Biological_membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016032 name: viral process namespace: biological_process alt_id: GO:0022415 def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. subset: goslim_metagenomics subset: goslim_pir synonym: "viral infection" RELATED [] synonym: "virulence" RELATED [] synonym: "virus process" EXACT [GOC:bf, GOC:jl] xref: Reactome:REACT_6145 "Influenza Life Cycle, Homo sapiens" xref: Reactome:REACT_6185 "HIV Infection, Homo sapiens" xref: Reactome:REACT_6256 "HIV Life Cycle, Homo sapiens" xref: Wikipedia:Viral_life_cycle is_a: GO:0008150 ! biological_process [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir synonym: "RNA metabolism" EXACT [] xref: Reactome:REACT_107259 "Metabolism of RNA, Sus scrofa" xref: Reactome:REACT_107652 "Metabolism of RNA, Schizosaccharomyces pombe" xref: Reactome:REACT_110289 "Metabolism of RNA, Danio rerio" xref: Reactome:REACT_21257 "Metabolism of RNA, Homo sapiens" xref: Reactome:REACT_30579 "Metabolism of RNA, Xenopus tropicalis" xref: Reactome:REACT_31367 "Metabolism of RNA, Dictyostelium discoideum" xref: Reactome:REACT_33720 "Metabolism of RNA, Plasmodium falciparum" xref: Reactome:REACT_80071 "Metabolism of RNA, Caenorhabditis elegans" xref: Reactome:REACT_83630 "Metabolism of RNA, Taeniopygia guttata" xref: Reactome:REACT_84169 "Metabolism of RNA, Canis familiaris" xref: Reactome:REACT_85788 "Metabolism of RNA, Oryza sativa" xref: Reactome:REACT_88316 "Metabolism of RNA, Mus musculus" xref: Reactome:REACT_89992 "Metabolism of RNA, Saccharomyces cerevisiae" xref: Reactome:REACT_91556 "Metabolism of RNA, Bos taurus" xref: Reactome:REACT_92152 "Metabolism of RNA, Drosophila melanogaster" xref: Reactome:REACT_94876 "Metabolism of RNA, Arabidopsis thaliana" xref: Reactome:REACT_99403 "Metabolism of RNA, Rattus norvegicus" xref: Reactome:REACT_99885 "Metabolism of RNA, Gallus gallus" is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0016209 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0003674 ! molecular_function relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0016226 name: iron-sulfur cluster assembly namespace: biological_process def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] subset: goslim_metagenomics synonym: "iron-sulfur cluster biosynthesis" RELATED [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0071840 ! cellular component organization or biogenesis relationship: part_of GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:REACT_100073 "Activation of S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_100078 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus" xref: Reactome:REACT_100260 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Taeniopygia guttata" xref: Reactome:REACT_100298 "Phosphorylation of L1 by CK-II, Rattus norvegicus" xref: Reactome:REACT_100305 "Regulation of NUDC by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris" xref: Reactome:REACT_100390 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Canis familiaris" xref: Reactome:REACT_100465 "Phosphorylation and inactivation of eEF2K by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_100495 "Cdc6 protein is phosphorylated by CDK, Xenopus tropicalis" xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus" xref: Reactome:REACT_100636 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_100637 "Phosphorylation of the Scc1:Cohesion Complex, Mus musculus" xref: Reactome:REACT_101024 "Phosphorylation and inactivation of eEF2K by activated S6K1, Bos taurus" xref: Reactome:REACT_101170 "Phosphorylation of APC component of the destruction complex, Drosophila melanogaster" xref: Reactome:REACT_101303 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Mus musculus" xref: Reactome:REACT_101431 "Mcm2-7 is phosphorylated by DDK, Danio rerio" xref: Reactome:REACT_101543 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Canis familiaris" xref: Reactome:REACT_101596 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Canis familiaris" xref: Reactome:REACT_101638 "Phosphorylation and activation of CHK2 by ATM, Bos taurus" xref: Reactome:REACT_101667 "Down Regulation of Emi1 through Phosphorylation of Emi1, Bos taurus" xref: Reactome:REACT_101841 "Phosphorylation of Cdc25C at Ser216, Rattus norvegicus" xref: Reactome:REACT_101862 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Xenopus tropicalis" xref: Reactome:REACT_101914 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_102090 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_102093 "Phosphorylation and activation of eIF4G by activated S6K1, Danio rerio" xref: Reactome:REACT_102154 "Autophosphorylation of PAK-2p34 in the activation loop, Schizosaccharomyces pombe" xref: Reactome:REACT_102322 "RAF1 phosphorylates MEK2, Danio rerio" xref: Reactome:REACT_102330 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_102380 "Regulation of KIF23 (MKLP1) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus" xref: Reactome:REACT_102499 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_102552 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Canis familiaris" xref: Reactome:REACT_102607 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Drosophila melanogaster" xref: Reactome:REACT_102711 "Phosphorylation of L1 by CK-II, Caenorhabditis elegans" xref: Reactome:REACT_102729 "RAF1 phosphorylates MEK1, Xenopus tropicalis" xref: Reactome:REACT_102817 "Phosphorylation of L1 by ERK, Mus musculus" xref: Reactome:REACT_102887 "Mcm2-7 is phosphorylated by DDK, Rattus norvegicus" xref: Reactome:REACT_102908 "Phosphorylation of the Scc1:Cohesion Complex, Rattus norvegicus" xref: Reactome:REACT_102915 "Activation of S6K1, Arabidopsis thaliana" xref: Reactome:REACT_103060 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Arabidopsis thaliana" xref: Reactome:REACT_103291 "Phosphorylation of complexed TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_103327 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_103359 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster" xref: Reactome:REACT_103691 "Phosphorylation of COP1 at Ser-387 by ATM, Xenopus tropicalis" xref: Reactome:REACT_103727 "Phosphorylation of NBS1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_103804 "Phosphorylation of AKT2 by PDK1, Canis familiaris" xref: Reactome:REACT_103989 "Phosphorylation of NBS1 by ATM, Danio rerio" xref: Reactome:REACT_104022 "Phosphorylation of p53 at ser-15 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_104044 "Phosphorylation and activation of Chk1 by ATM, Sus scrofa" xref: Reactome:REACT_104109 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_104209 "Activation of S6K1, Caenorhabditis elegans" xref: Reactome:REACT_104323 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_104386 "Phosphorylation and activation of eIF4B by activated S6K1, Bos taurus" xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus" xref: Reactome:REACT_104644 "Regulation of KIF20A (MKL2) by phosphorylation, Bos taurus" xref: Reactome:REACT_104687 "Phosphorylation of L1 by CK-II, Canis familiaris" xref: Reactome:REACT_104730 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Schizosaccharomyces pombe" xref: Reactome:REACT_104822 "Phosphorylation of COP1 at Ser-387 by ATM, Rattus norvegicus" xref: Reactome:REACT_104837 "SOS phosphorylation and dissociation (SHC), Mus musculus" xref: Reactome:REACT_104878 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Xenopus tropicalis" xref: Reactome:REACT_105254 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Danio rerio" xref: Reactome:REACT_105274 "Regulation of KIF20A (MKL2) by phosphorylation, Danio rerio" xref: Reactome:REACT_105345 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_105373 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Gallus gallus" xref: Reactome:REACT_105503 "Phosphorylation of L1 by ERK, Bos taurus" xref: Reactome:REACT_105561 "Phosphorylation of complexed TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_105569 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_105589 "Phosphorylation of p53 at ser-15 by ATM kinase, Canis familiaris" xref: Reactome:REACT_105664 "Akt1 phosphorylates BAD protein, Rattus norvegicus" xref: Reactome:REACT_105700 "Phosphorylation of PDE3B, Rattus norvegicus" xref: Reactome:REACT_105971 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Xenopus tropicalis" xref: Reactome:REACT_105976 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Xenopus tropicalis" xref: Reactome:REACT_106075 "Akt1 phosphorylates BAD protein, Canis familiaris" xref: Reactome:REACT_106144 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_106159 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_106186 "Phosphorylation of TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_106225 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Canis familiaris" xref: Reactome:REACT_1063 "Phosphorylation of Wee1 kinase by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus" xref: Reactome:REACT_106383 "Phosphorylation of L1 by ERK, Xenopus tropicalis" xref: Reactome:REACT_106411 "Phosphorylation and inactivation of eEF2K by activated S6K1, Gallus gallus" xref: Reactome:REACT_106420 "Regulation of KIF23 (MKLP1) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_106500 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Drosophila melanogaster" xref: Reactome:REACT_106505 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Rattus norvegicus" xref: Reactome:REACT_106514 "Phosphorylation of NBS1 by ATM, Mus musculus" xref: Reactome:REACT_106567 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Mus musculus" xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis" xref: Reactome:REACT_106681 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Rattus norvegicus" xref: Reactome:REACT_106722 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_106738 "SOS phosphorylation and dissociation (IRS, Crk), Canis familiaris" xref: Reactome:REACT_106897 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Danio rerio" xref: Reactome:REACT_107009 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_107055 "Phosphorylation of Cdc25C at Ser216, Bos taurus" xref: Reactome:REACT_107102 "SOS phosphorylation and dissociation (IRS, Crk), Danio rerio" xref: Reactome:REACT_107243 "Phosphorylation of APC component of the destruction complex, Mus musculus" xref: Reactome:REACT_107247 "Phosphorylation of TSC2 by PKB, Mus musculus" xref: Reactome:REACT_107310 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris" xref: Reactome:REACT_107623 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Mus musculus" xref: Reactome:REACT_107685 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Sus scrofa" xref: Reactome:REACT_107732 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Danio rerio" xref: Reactome:REACT_107736 "Phosphorylation of Cdc25C at Ser216, Sus scrofa" xref: Reactome:REACT_107787 "Phosphorylation and activation of CHK2 by ATM, Drosophila melanogaster" xref: Reactome:REACT_107849 "Phosphorylation of DLC2 by MAPK-8, Bos taurus" xref: Reactome:REACT_107854 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Canis familiaris" xref: Reactome:REACT_108002 "Plk1-mediated phosphorylation of Nlp, Bos taurus" xref: Reactome:REACT_108096 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Rattus norvegicus" xref: Reactome:REACT_108132 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Gallus gallus" xref: Reactome:REACT_108362 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio" xref: Reactome:REACT_108520 "Phosphorylation and activation of Chk1 by ATM, Danio rerio" xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis" xref: Reactome:REACT_108776 "Free APC/C phosphorylated by Plk1, Taeniopygia guttata" xref: Reactome:REACT_108840 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Canis familiaris" xref: Reactome:REACT_108871 "Free APC/C phosphorylated by Plk1, Mus musculus" xref: Reactome:REACT_108971 "Phosphorylation of Cyclin B1 in the CRS domain, Xenopus tropicalis" xref: Reactome:REACT_108985 "Phosphorylation of cPLA2 by ERK-2, Gallus gallus" xref: Reactome:REACT_109045 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_109065 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Taeniopygia guttata" xref: Reactome:REACT_109117 "Phosphorylation of 4E-BP1 by activated mTORC1, Dictyostelium discoideum" xref: Reactome:REACT_109197 "SOS phosphorylation and dissociation (IRS), Mus musculus" xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe" xref: Reactome:REACT_109260 "Free APC/C phosphorylated by Plk1, Xenopus tropicalis" xref: Reactome:REACT_109264 "SOS phosphorylation and dissociation (IRS), Canis familiaris" xref: Reactome:REACT_109331 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Drosophila melanogaster" xref: Reactome:REACT_109367 "Phosphorylation of APC component of the destruction complex, Gallus gallus" xref: Reactome:REACT_109549 "Regulation of KIF20A (MKL2) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_109641 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_109769 "Free APC/C phosphorylated by Plk1, Gallus gallus" xref: Reactome:REACT_109799 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Mus musculus" xref: Reactome:REACT_110175 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Mus musculus" xref: Reactome:REACT_110254 "Phosphorylation of APC component of the destruction complex, Rattus norvegicus" xref: Reactome:REACT_110296 "Phosphorylation and activation of Chk1 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_110351 "Phosphorylation and inactivation of eEF2K by activated S6K1, Canis familiaris" xref: Reactome:REACT_110382 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Oryza sativa" xref: Reactome:REACT_110530 "Down Regulation of Emi1 through Phosphorylation of Emi1, Mus musculus" xref: Reactome:REACT_110583 "Phosphorylation of DLC2 by MAPK-8, Mus musculus" xref: Reactome:REACT_110643 "Mcm2-7 is phosphorylated by DDK, Xenopus tropicalis" xref: Reactome:REACT_110679 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Danio rerio" xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster" xref: Reactome:REACT_110775 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Rattus norvegicus" xref: Reactome:REACT_110947 "Regulation of KIF23 (MKLP1) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_110995 "Phosphorylation and activation of eIF4G by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_111124 "FGFR associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_111171 "FGFR-associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens" xref: Reactome:REACT_111930 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Caenorhabditis elegans" xref: Reactome:REACT_1120 "Regulation of KIF20A (MKL2) by phosphorylation, Homo sapiens" xref: Reactome:REACT_112075 "Mcm2-7 is phosphorylated by DDK, Drosophila melanogaster" xref: Reactome:REACT_112101 "Phosphorylation of L1 by CK-II, Xenopus tropicalis" xref: Reactome:REACT_112156 "Phosphorylation of AKT2 by PDK1, Saccharomyces cerevisiae" xref: Reactome:REACT_112214 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Schizosaccharomyces pombe" xref: Reactome:REACT_112270 "Akt1 phosphorylates BAD protein, Xenopus tropicalis" xref: Reactome:REACT_112298 "Autophosphorylation of DNA-PKcs, Dictyostelium discoideum" xref: Reactome:REACT_112324 "Phosphorylation and activation of eIF4G by activated S6K1, Oryza sativa" xref: Reactome:REACT_112360 "Regulation of KIF23 (MKLP1) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_112413 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_112545 "Phosphorylation and activation of eIF4G by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_112633 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112709 "Phosphorylation of L1 by ERK, Saccharomyces cerevisiae" xref: Reactome:REACT_112722 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Drosophila melanogaster" xref: Reactome:REACT_112790 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Caenorhabditis elegans" xref: Reactome:REACT_112846 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Saccharomyces cerevisiae" xref: Reactome:REACT_112892 "Phosphorylation of BRCA1 at multiple sites by ATM, Oryza sativa" xref: Reactome:REACT_112948 "Autophosphorylation of DNA-PKcs, Rattus norvegicus" xref: Reactome:REACT_113022 "Phosphorylation of Cyclin B1 in the CRS domain, Schizosaccharomyces pombe" xref: Reactome:REACT_113051 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Arabidopsis thaliana" xref: Reactome:REACT_113121 "Phosphorylation and activation of eIF4B by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_113227 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113244 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_113269 "Activation of S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113435 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Oryza sativa" xref: Reactome:REACT_113527 "Autophosphorylation of DNA-PKcs, Bos taurus" xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae" xref: Reactome:REACT_113811 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Bos taurus" xref: Reactome:REACT_113820 "Phosphorylation of Cyclin B1 in the CRS domain, Saccharomyces cerevisiae" xref: Reactome:REACT_113894 "PIP2 conversion to PIP3, Caenorhabditis elegans" xref: Reactome:REACT_113929 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Caenorhabditis elegans" xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe" xref: Reactome:REACT_114160 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_114198 "Phosphorylation of the Scc1:Cohesion Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_114207 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_114227 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Schizosaccharomyces pombe" xref: Reactome:REACT_114233 "Autophosphorylation of DNA-PKcs, Sus scrofa" xref: Reactome:REACT_114255 "Autophosphorylation of DNA-PKcs, Mus musculus" xref: Reactome:REACT_114268 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Schizosaccharomyces pombe" xref: Reactome:REACT_114280 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Saccharomyces cerevisiae" xref: Reactome:REACT_114319 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Caenorhabditis elegans" xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans" xref: Reactome:REACT_114395 "Phosphorylation of DLC1 by MAPK 8, Xenopus tropicalis" xref: Reactome:REACT_114434 "Autophosphorylation of DNA-PKcs, Taeniopygia guttata" xref: Reactome:REACT_114461 "Phosphorylation of AKT2 by PDK1, Schizosaccharomyces pombe" xref: Reactome:REACT_114522 "Phosphorylation of BRCA1 at multiple sites by ATM, Arabidopsis thaliana" xref: Reactome:REACT_114553 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Saccharomyces cerevisiae" xref: Reactome:REACT_114599 "Phosphorylation of TSC2 by PKB, Schizosaccharomyces pombe" xref: Reactome:REACT_114624 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Drosophila melanogaster" xref: Reactome:REACT_114771 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Canis familiaris" xref: Reactome:REACT_114906 "Phosphorylation and activation of eIF4G by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_114984 "Autophosphorylation of DNA-PKcs, Xenopus tropicalis" xref: Reactome:REACT_115006 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Caenorhabditis elegans" xref: Reactome:REACT_115135 "Phosphorylation and activation of eIF4G by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_115168 "Autophosphorylation of DNA-PKcs, Gallus gallus" xref: Reactome:REACT_115199 "Autophosphorylation of DNA-PKcs, Canis familiaris" xref: Reactome:REACT_115358 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Drosophila melanogaster" xref: Reactome:REACT_115384 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_115440 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Danio rerio" xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_115475 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115521 "Autophosphorylation of DNA-PKcs, Danio rerio" xref: Reactome:REACT_115527 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115747 "Phosphorylation of H2AX at S139 by ATM at the site of DSB, Gallus gallus" xref: Reactome:REACT_116149 "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members, Gallus gallus" xref: Reactome:REACT_118137 "Phosphorylation of the Scc1:Cohesion Complex, Taeniopygia guttata" xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata" xref: Reactome:REACT_118284 "Phosphorylation of the Scc1:Cohesion Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus" xref: Reactome:REACT_118367 "Phosphorylation of the Scc1:Cohesion Complex, Gallus gallus" xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_1185 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_1279 "Cdc6 protein is phosphorylated by CDK, Homo sapiens" xref: Reactome:REACT_128 "Phosphorylation of Cdc25C at Ser216, Homo sapiens" xref: Reactome:REACT_132 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Homo sapiens" xref: Reactome:REACT_1326 "Regulation of NUDC by phosphorylation, Homo sapiens" xref: Reactome:REACT_13431 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Homo sapiens" xref: Reactome:REACT_13581 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Oryctolagus cuniculus" xref: Reactome:REACT_1362 "Phosphorylation of the Scc1:Cohesion Complex, Homo sapiens" xref: Reactome:REACT_13817 "Autophosphorylation of PAK-2p34, Oryctolagus cuniculus" xref: Reactome:REACT_1382 "Phosphorylation of PDE3B by AKT-1, Mus musculus" xref: Reactome:REACT_13820 "Autophosphorylation of PAK-2p34 in the activation loop, Homo sapiens" xref: Reactome:REACT_1420 "SOS phosphorylation and dissociation (SHC), Homo sapiens" xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens" xref: Reactome:REACT_1517 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Homo sapiens" xref: Reactome:REACT_15386 "Plk1-mediated phosphorylation of Nlp, Homo sapiens" xref: Reactome:REACT_1603 "Phosphorylation and activation of CHK2 by ATM, Homo sapiens" xref: Reactome:REACT_1657 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_1680 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Homo sapiens" xref: Reactome:REACT_169 "SOS phosphorylation and dissociation (IRS), Homo sapiens" xref: Reactome:REACT_1727 "RAF1 phosphorylates MEK2, Homo sapiens" xref: Reactome:REACT_1756 "Phosphorylation of p53 at ser-15 by ATM kinase, Homo sapiens" xref: Reactome:REACT_1782 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Homo sapiens" xref: Reactome:REACT_1808 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Homo sapiens" xref: Reactome:REACT_1878 "Phosphorylation of PDE3B, Homo sapiens" xref: Reactome:REACT_188 "Akt1 phosphorylates BAD protein, Homo sapiens" xref: Reactome:REACT_1888 "Phosphorylation of DLC1 by MAPK 8, Homo sapiens" xref: Reactome:REACT_1930 "Regulation of KIF23 (MKLP1) by phosphorylation, Homo sapiens" xref: Reactome:REACT_19312 "Phosphorylation of PD-1, Homo sapiens" xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens" xref: Reactome:REACT_1981 "Phosphorylation of DLC2 by MAPK-8, Homo sapiens" xref: Reactome:REACT_2009 "Phosphorylation of NBS1 by ATM, Homo sapiens" xref: Reactome:REACT_203 "Raf1 phosphorylates MEK1, Rattus norvegicus" xref: Reactome:REACT_20503 "Phosphorylation of CREB by ribosomal protein S6 kinase, Homo sapiens" xref: Reactome:REACT_20543 "Phosphorylation of COP1 at Ser-387 by ATM, Homo sapiens" xref: Reactome:REACT_20562 "Phosphorylation by MAPK/ERK, Homo sapiens" xref: Reactome:REACT_20578 "Raf activation, Homo sapiens" xref: Reactome:REACT_20583 "Phosphorylation of CREB by PKA, Homo sapiens" xref: Reactome:REACT_20631 "Activation of MAPK, Homo sapiens" xref: Reactome:REACT_20640 "Phophorylation by PDK1, Homo sapiens" xref: Reactome:REACT_2066 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_2111 "Orc1 is phosphorylated by cyclin A/CDK2, Homo sapiens" xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens" xref: Reactome:REACT_215 "Autophosphorylation of DNA-PKcs, Homo sapiens" xref: Reactome:REACT_22099 "Phosphorylation of L1 by ERK, Homo sapiens" xref: Reactome:REACT_22378 "Phosphorylation of L1 by CK-II, Homo sapiens" xref: Reactome:REACT_23976 "Raf1 phosphorylates MEK2, Rattus norvegicus" xref: Reactome:REACT_23990 "Phosphorylation of cPLA2 by ERK-2, Homo sapiens" xref: Reactome:REACT_244 "PIP2 conversion to PIP3, Homo sapiens" xref: Reactome:REACT_26 "SOS phosphorylation and dissociation (IRS, Crk), Homo sapiens" xref: Reactome:REACT_264 "Phosphorylation of Wee1 kinase by Chk1, Homo sapiens" xref: Reactome:REACT_28054 "Phosphorylation of BRCA1 at multiple sites by ATM, Mus musculus" xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris" xref: Reactome:REACT_28113 "RAF1 phosphorylates MEK1, Taeniopygia guttata" xref: Reactome:REACT_28163 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Canis familiaris" xref: Reactome:REACT_28264 "Phosphorylation of Wee1 kinase by Chk1, Arabidopsis thaliana" xref: Reactome:REACT_28480 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Danio rerio" xref: Reactome:REACT_28555 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Xenopus tropicalis" xref: Reactome:REACT_28681 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Rattus norvegicus" xref: Reactome:REACT_28719 "Phosphorylation and activation of eIF4B by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_28743 "RAF1 phosphorylates MEK2, Mus musculus" xref: Reactome:REACT_28746 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Danio rerio" xref: Reactome:REACT_28824 "Down Regulation of Emi1 through Phosphorylation of Emi1, Danio rerio" xref: Reactome:REACT_29029 "Phosphorylation of L1 by ERK, Caenorhabditis elegans" xref: Reactome:REACT_29168 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Canis familiaris" xref: Reactome:REACT_29201 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Saccharomyces cerevisiae" xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus" xref: Reactome:REACT_29277 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_29284 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Xenopus tropicalis" xref: Reactome:REACT_29289 "Activation of S6K1, Gallus gallus" xref: Reactome:REACT_29300 "Phosphorylation of L1 by ERK, Drosophila melanogaster" xref: Reactome:REACT_29334 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_29395 "Phosphorylation of AKT2 by PDK1, Xenopus tropicalis" xref: Reactome:REACT_29396 "Orc1 is phosphorylated by cyclin A/CDK2, Canis familiaris" xref: Reactome:REACT_29410 "Regulation of KIF20A (MKL2) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29451 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Bos taurus" xref: Reactome:REACT_29588 "Phosphorylation of 4E-BP1 by activated mTORC1, Taeniopygia guttata" xref: Reactome:REACT_29614 "Regulation of NUDC by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29689 "Cdc6 protein is phosphorylated by CDK, Bos taurus" xref: Reactome:REACT_29694 "Phosphorylation of PDE3B, Canis familiaris" xref: Reactome:REACT_29759 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Bos taurus" xref: Reactome:REACT_29788 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_29873 "Phosphorylation of APC component of the destruction complex, Taeniopygia guttata" xref: Reactome:REACT_29914 "Down Regulation of Emi1 through Phosphorylation of Emi1, Canis familiaris" xref: Reactome:REACT_30020 "Phosphorylation (Ser5) of RNA pol II CTD, Rattus norvegicus" xref: Reactome:REACT_30023 "Phosphorylation (Ser5) of RNA pol II CTD, Xenopus tropicalis" xref: Reactome:REACT_30052 "Phosphorylation of BRCA1 at multiple sites by ATM, Bos taurus" xref: Reactome:REACT_30070 "Phosphorylation of L1 by CK-II, Mus musculus" xref: Reactome:REACT_30084 "PIP2 conversion to PIP3, Canis familiaris" xref: Reactome:REACT_30113 "SOS phosphorylation and dissociation (IRS, Crk), Drosophila melanogaster" xref: Reactome:REACT_30116 "Phosphorylation and activation of eIF4B by activated S6K1, Canis familiaris" xref: Reactome:REACT_30165 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Gallus gallus" xref: Reactome:REACT_302 "Phosphorylation and activation of Chk1 by ATM, Homo sapiens" xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans" xref: Reactome:REACT_30345 "RAF1 phosphorylates MEK1, Gallus gallus" xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio" xref: Reactome:REACT_30496 "Phosphorylation of the Scc1:Cohesion Complex, Xenopus tropicalis" xref: Reactome:REACT_30679 "Phosphorylation and inactivation of eEF2K by activated S6K1, Mus musculus" xref: Reactome:REACT_30700 "Phosphorylation of BRCA1 at multiple sites by ATM, Gallus gallus" xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus" xref: Reactome:REACT_30921 "Phosphorylation and activation of Chk1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_30938 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Canis familiaris" xref: Reactome:REACT_30948 "PIP2 conversion to PIP3, Gallus gallus" xref: Reactome:REACT_30985 "Plk1-mediated phosphorylation of Nlp, Canis familiaris" xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus" xref: Reactome:REACT_31081 "Phosphorylation of TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_31149 "Phosphorylation of the Scc1:Cohesion Complex, Danio rerio" xref: Reactome:REACT_31196 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Canis familiaris" xref: Reactome:REACT_31227 "Regulation of KIF20A (MKL2) by phosphorylation, Gallus gallus" xref: Reactome:REACT_31273 "Phosphorylation of the Scc1:Cohesion Complex, Canis familiaris" xref: Reactome:REACT_31290 "Orc1 is phosphorylated by cyclin A/CDK2, Rattus norvegicus" xref: Reactome:REACT_31293 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Danio rerio" xref: Reactome:REACT_31449 "Phosphorylation and activation of CHK2 by ATM, Danio rerio" xref: Reactome:REACT_31466 "Activation of S6K1, Bos taurus" xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio" xref: Reactome:REACT_31536 "Phosphorylation of NBS1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_31571 "Autophosphorylation of PAK-2p34 in the activation loop, Gallus gallus" xref: Reactome:REACT_31625 "Phosphorylation of L1 by ERK, Taeniopygia guttata" xref: Reactome:REACT_31639 "SOS phosphorylation and dissociation (SHC), Rattus norvegicus" xref: Reactome:REACT_31868 "Phosphorylation and activation of CHK2 by ATM, Canis familiaris" xref: Reactome:REACT_31915 "Phosphorylation of L1 by CK-II, Drosophila melanogaster" xref: Reactome:REACT_31935 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Sus scrofa" xref: Reactome:REACT_31984 "Phosphorylation (Ser5) of RNA pol II CTD, Arabidopsis thaliana" xref: Reactome:REACT_32009 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_32079 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Danio rerio" xref: Reactome:REACT_32145 "Phosphorylation of COP1 at Ser-387 by ATM, Canis familiaris" xref: Reactome:REACT_32150 "Phosphorylation of NBS1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_32271 "Phosphorylation of cPLA2 by ERK-2, Taeniopygia guttata" xref: Reactome:REACT_32358 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Canis familiaris" xref: Reactome:REACT_32374 "Mcm2-7 is phosphorylated by DDK, Canis familiaris" xref: Reactome:REACT_32438 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_32492 "Phosphorylation of BRCA1 at multiple sites by ATM, Rattus norvegicus" xref: Reactome:REACT_32565 "Phosphorylation of NBS1 by ATM, Gallus gallus" xref: Reactome:REACT_32598 "Phosphorylation and activation of eIF4B by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_32620 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Bos taurus" xref: Reactome:REACT_32845 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Rattus norvegicus" xref: Reactome:REACT_32906 "Phosphorylation and inactivation of eEF2K by activated S6K1, Sus scrofa" xref: Reactome:REACT_32956 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Mus musculus" xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum" xref: Reactome:REACT_33009 "Phosphorylation of L1 by ERK, Danio rerio" xref: Reactome:REACT_33080 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Taeniopygia guttata" xref: Reactome:REACT_33369 "Phosphorylation of NBS1 by ATM, Rattus norvegicus" xref: Reactome:REACT_33385 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Canis familiaris" xref: Reactome:REACT_33519 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Mus musculus" xref: Reactome:REACT_33532 "Phosphorylation of complexed TSC2 by PKB, Bos taurus" xref: Reactome:REACT_33692 "Phosphorylation of BRCA1 at multiple sites by ATM, Taeniopygia guttata" xref: Reactome:REACT_33840 "Regulation of KIF23 (MKLP1) by phosphorylation, Schizosaccharomyces pombe" xref: Reactome:REACT_33928 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Sus scrofa" xref: Reactome:REACT_33979 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Rattus norvegicus" xref: Reactome:REACT_34080 "Phosphorylation of PD-1, Mus musculus" xref: Reactome:REACT_34111 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Canis familiaris" xref: Reactome:REACT_34145 "Phosphorylation of cPLA2 by ERK-2, Xenopus tropicalis" xref: Reactome:REACT_34222 "Phosphorylation of L1 by ERK, Rattus norvegicus" xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus" xref: Reactome:REACT_34310 "Phosphorylation and activation of Chk1 by ATM, Bos taurus" xref: Reactome:REACT_34403 "Phosphorylation (Ser5) of RNA pol II CTD, Danio rerio" xref: Reactome:REACT_34514 "Phosphorylation and inactivation of eEF2K by activated S6K1, Danio rerio" xref: Reactome:REACT_34516 "Cdc6 protein is phosphorylated by CDK, Canis familiaris" xref: Reactome:REACT_34607 "Phosphorylation of 4E-BP1 by activated mTORC1, Bos taurus" xref: Reactome:REACT_34741 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Rattus norvegicus" xref: Reactome:REACT_34788 "Phosphorylation and inactivation of eEF2K by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_34804 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Gallus gallus" xref: Reactome:REACT_384 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens" xref: Reactome:REACT_41715 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Mus musculus" xref: Reactome:REACT_43 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Homo sapiens" xref: Reactome:REACT_496 "Down Regulation of Emi1 through Phosphorylation of Emi1, Homo sapiens" xref: Reactome:REACT_54449 "Phosphorylation and activation of eIF4G by activated S6K1, Mus musculus" xref: Reactome:REACT_545 "RAF1 phosphorylates MEK1, Homo sapiens" xref: Reactome:REACT_559 "Phosphorylation and activation of Chk1 by ATM kinase, Mus musculus" xref: Reactome:REACT_58131 "PIP2 conversion to PIP3, Mus musculus" xref: Reactome:REACT_6139 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6170 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6178 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6234 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_6297 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_6311 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6314 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6316 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex, Human immunodeficiency virus 1" xref: Reactome:REACT_6327 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6342 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Homo sapiens" xref: Reactome:REACT_6353 "Phosphorylation of Cyclin B1 in the CRS domain, Homo sapiens" xref: Reactome:REACT_6725 "Phosphorylation of TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_6778 "Phosphorylation and activation of eIF4B by activated S6K1, Homo sapiens" xref: Reactome:REACT_6859 "Free APC/C phosphorylated by Plk1, Homo sapiens" xref: Reactome:REACT_6861 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Homo sapiens" xref: Reactome:REACT_6870 "Phosphorylation and activation of eIF4G by activated S6K1, Homo sapiens" xref: Reactome:REACT_6873 "Phosphorylation of 4E-BP1 by activated mTORC1, Homo sapiens" xref: Reactome:REACT_6883 "Phosphorylation and inactivation of eEF2K by activated S6K1, Homo sapiens" xref: Reactome:REACT_6912 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Homo sapiens" xref: Reactome:REACT_6948 "Activation of S6K1, Homo sapiens" xref: Reactome:REACT_6952 "Phosphorylation of complexed TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_76979 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Danio rerio" xref: Reactome:REACT_77040 "Phosphorylation of COP1 at Ser-387 by ATM, Oryza sativa" xref: Reactome:REACT_77074 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Mus musculus" xref: Reactome:REACT_77179 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Bos taurus" xref: Reactome:REACT_77231 "Phosphorylation of DLC2 by MAPK-8, Gallus gallus" xref: Reactome:REACT_77234 "Plk1-mediated phosphorylation of Nlp, Gallus gallus" xref: Reactome:REACT_773 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Homo sapiens" xref: Reactome:REACT_77326 "RAF1 phosphorylates MEK2, Taeniopygia guttata" xref: Reactome:REACT_77362 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Rattus norvegicus" xref: Reactome:REACT_77365 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Xenopus tropicalis" xref: Reactome:REACT_77397 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Mus musculus" xref: Reactome:REACT_77407 "Regulation of NUDC by phosphorylation, Bos taurus" xref: Reactome:REACT_77443 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Danio rerio" xref: Reactome:REACT_77450 "Phosphorylation of L1 by CK-II, Sus scrofa" xref: Reactome:REACT_77535 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Mus musculus" xref: Reactome:REACT_77550 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_77566 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_77606 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Canis familiaris" xref: Reactome:REACT_77615 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Gallus gallus" xref: Reactome:REACT_77654 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_77660 "Regulation of KIF23 (MKLP1) by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_77733 "Phosphorylation of PDE3B, Danio rerio" xref: Reactome:REACT_77834 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Rattus norvegicus" xref: Reactome:REACT_77857 "Phosphorylation (Ser5) of RNA pol II CTD, Drosophila melanogaster" xref: Reactome:REACT_77897 "Phosphorylation of Wee1 kinase by Chk1, Taeniopygia guttata" xref: Reactome:REACT_77911 "Mcm2-7 is phosphorylated by DDK, Taeniopygia guttata" xref: Reactome:REACT_77928 "Autophosphorylation of PAK-2p34 in the activation loop, Sus scrofa" xref: Reactome:REACT_77949 "Phosphorylation of Wee1 kinase by Chk1, Drosophila melanogaster" xref: Reactome:REACT_77977 "Phosphorylation of Cyclin B1 in the CRS domain, Bos taurus" xref: Reactome:REACT_78014 "Plk1-mediated phosphorylation of Nlp, Taeniopygia guttata" xref: Reactome:REACT_78035 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_78087 "Phosphorylation of TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_78121 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Gallus gallus" xref: Reactome:REACT_78226 "Regulation of NUDC by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_78281 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_78427 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Danio rerio" xref: Reactome:REACT_78450 "Phosphorylation and activation of eIF4B by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_78451 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_78503 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Bos taurus" xref: Reactome:REACT_78533 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_78539 "Down Regulation of Emi1 through Phosphorylation of Emi1, Xenopus tropicalis" xref: Reactome:REACT_78556 "Free APC/C phosphorylated by Plk1, Drosophila melanogaster" xref: Reactome:REACT_78625 "Phosphorylation and inactivation of eEF2K by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_78651 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_78696 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_78748 "Cdc6 protein is phosphorylated by CDK, Drosophila melanogaster" xref: Reactome:REACT_78901 "Phosphorylation (Ser5) of RNA pol II CTD, Mus musculus" xref: Reactome:REACT_79012 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Schizosaccharomyces pombe" xref: Reactome:REACT_79039 "Autophosphorylation of PAK-2p34 in the activation loop, Caenorhabditis elegans" xref: Reactome:REACT_79087 "Phosphorylation of Wee1 kinase by Chk1, Oryza sativa" xref: Reactome:REACT_79125 "SOS phosphorylation and dissociation (IRS), Bos taurus" xref: Reactome:REACT_79182 "Phosphorylation of Cyclin B1 in the CRS domain, Canis familiaris" xref: Reactome:REACT_79208 "Mcm2-7 is phosphorylated by DDK, Bos taurus" xref: Reactome:REACT_79220 "Phosphorylation of 4E-BP1 by activated mTORC1, Canis familiaris" xref: Reactome:REACT_79255 "Phosphorylation of p53 at ser-15 by ATM kinase, Danio rerio" xref: Reactome:REACT_79372 "Cdc6 protein is phosphorylated by CDK, Danio rerio" xref: Reactome:REACT_79573 "Phosphorylation of p53 at ser-15 by ATM kinase, Mus musculus" xref: Reactome:REACT_79686 "Phosphorylation of the Scc1:Cohesion Complex, Drosophila melanogaster" xref: Reactome:REACT_79694 "Autophosphorylation of PAK-2p34 in the activation loop, Xenopus tropicalis" xref: Reactome:REACT_79700 "Activation of S6K1, Taeniopygia guttata" xref: Reactome:REACT_79709 "Orc1 is phosphorylated by cyclin A/CDK2, Mus musculus" xref: Reactome:REACT_79720 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_80110 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_80144 "Phosphorylation of complexed TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_80185 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_80213 "Activation of S6K1, Canis familiaris" xref: Reactome:REACT_80218 "Phosphorylation of the Scc1:Cohesion Complex, Dictyostelium discoideum" xref: Reactome:REACT_80239 "Regulation of KIF20A (MKL2) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_80255 "Mcm2-7 is phosphorylated by DDK, Mus musculus" xref: Reactome:REACT_80591 "Regulation of KIF20A (MKL2) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_80606 "Phosphorylation of NBS1 by ATM, Oryza sativa" xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis" xref: Reactome:REACT_80632 "Phosphorylation of L1 by ERK, Schizosaccharomyces pombe" xref: Reactome:REACT_80665 "Down Regulation of Emi1 through Phosphorylation of Emi1, Taeniopygia guttata" xref: Reactome:REACT_80684 "Phosphorylation of COP1 at Ser-387 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa" xref: Reactome:REACT_80699 "PIP2 conversion to PIP3, Danio rerio" xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa" xref: Reactome:REACT_80714 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_80804 "Phosphorylation of PDE3B, Bos taurus" xref: Reactome:REACT_80853 "Phosphorylation (Ser5) of RNA pol II CTD, Dictyostelium discoideum" xref: Reactome:REACT_80860 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_80909 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Drosophila melanogaster" xref: Reactome:REACT_81027 "PIP2 conversion to PIP3, Sus scrofa" xref: Reactome:REACT_81148 "Phosphorylation and activation of CHK2 by ATM, Taeniopygia guttata" xref: Reactome:REACT_81218 "Phosphorylation and activation of CHK2 by ATM, Rattus norvegicus" xref: Reactome:REACT_81439 "Phosphorylation of APC component of the destruction complex, Xenopus tropicalis" xref: Reactome:REACT_81458 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Bos taurus" xref: Reactome:REACT_81490 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_81590 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_81616 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_81647 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_81652 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Rattus norvegicus" xref: Reactome:REACT_81693 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Drosophila melanogaster" xref: Reactome:REACT_81715 "Orc1 is phosphorylated by cyclin A/CDK2, Drosophila melanogaster" xref: Reactome:REACT_81727 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Danio rerio" xref: Reactome:REACT_81864 "Phosphorylation of Cx43 by c-src, Bos taurus" xref: Reactome:REACT_81941 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Bos taurus" xref: Reactome:REACT_82037 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Mus musculus" xref: Reactome:REACT_82115 "Phosphorylation and activation of Chk1 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_82125 "Phosphorylation of complexed TSC2 by PKB, Danio rerio" xref: Reactome:REACT_82128 "PIP2 conversion to PIP3, Taeniopygia guttata" xref: Reactome:REACT_82261 "Phosphorylation of DLC2 by MAPK-8, Xenopus tropicalis" xref: Reactome:REACT_82270 "Autophosphorylation of PAK-2p34 in the activation loop, Rattus norvegicus" xref: Reactome:REACT_82303 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Xenopus tropicalis" xref: Reactome:REACT_82310 "Phosphorylation and activation of Chk1 by ATM, Gallus gallus" xref: Reactome:REACT_82361 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_82456 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Bos taurus" xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris" xref: Reactome:REACT_82616 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Mus musculus" xref: Reactome:REACT_82678 "Phosphorylation of complexed TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_82728 "Plk1-mediated phosphorylation of Nlp, Mus musculus" xref: Reactome:REACT_82751 "Down Regulation of Emi1 through Phosphorylation of Emi1, Rattus norvegicus" xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus" xref: Reactome:REACT_82901 "Phosphorylation of DLC2 by MAPK-8, Canis familiaris" xref: Reactome:REACT_82927 "PIP2 conversion to PIP3, Rattus norvegicus" xref: Reactome:REACT_83006 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Caenorhabditis elegans" xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae" xref: Reactome:REACT_83110 "Phosphorylation (Ser5) of RNA pol II CTD, Schizosaccharomyces pombe" xref: Reactome:REACT_83178 "Phosphorylation and activation of Chk1 by ATM, Oryza sativa" xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus" xref: Reactome:REACT_83239 "Phosphorylation and activation of eIF4G by activated S6K1, Gallus gallus" xref: Reactome:REACT_83279 "Phosphorylation of NBS1 by ATM, Canis familiaris" xref: Reactome:REACT_83297 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana" xref: Reactome:REACT_83476 "Phosphorylation and activation of CHK2 by ATM, Mus musculus" xref: Reactome:REACT_83529 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_83533 "Phosphorylation and activation of Chk1 by ATM, Rattus norvegicus" xref: Reactome:REACT_83579 "Phosphorylation of Wee1 kinase by Chk1, Gallus gallus" xref: Reactome:REACT_83582 "Plk1-mediated phosphorylation of Nlp, Danio rerio" xref: Reactome:REACT_83671 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_83696 "Free APC/C phosphorylated by Plk1, Bos taurus" xref: Reactome:REACT_83709 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Mus musculus" xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus" xref: Reactome:REACT_83899 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Sus scrofa" xref: Reactome:REACT_83979 "Phosphorylation of COP1 at Ser-387 by ATM, Mus musculus" xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis" xref: Reactome:REACT_84082 "Phosphorylation of Wee1 kinase by Chk1, Rattus norvegicus" xref: Reactome:REACT_84208 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_84273 "Phosphorylation of L1 by ERK, Sus scrofa" xref: Reactome:REACT_84348 "Phosphorylation of COP1 at Ser-387 by ATM, Taeniopygia guttata" xref: Reactome:REACT_84405 "Phosphorylation of p53 at ser-15 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_845 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Homo sapiens" xref: Reactome:REACT_84560 "Cdc6 protein is phosphorylated by CDK, Saccharomyces cerevisiae" xref: Reactome:REACT_84656 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Bos taurus" xref: Reactome:REACT_84932 "Phosphorylation of Wee1 kinase by Chk1, Sus scrofa" xref: Reactome:REACT_85009 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Taeniopygia guttata" xref: Reactome:REACT_85017 "Activation of S6K1, Dictyostelium discoideum" xref: Reactome:REACT_85044 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_85066 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Taeniopygia guttata" xref: Reactome:REACT_85256 "Phosphorylation of Cdc25C at Ser216, Mus musculus" xref: Reactome:REACT_85328 "Regulation of KIF20A (MKL2) by phosphorylation, Mus musculus" xref: Reactome:REACT_85379 "Phosphorylation of Cx43 by c-src, Sus scrofa" xref: Reactome:REACT_85449 "Phosphorylation and activation of eIF4G by activated S6K1, Bos taurus" xref: Reactome:REACT_85586 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_85699 "Phosphorylation of Cyclin B1 in the CRS domain, Rattus norvegicus" xref: Reactome:REACT_85720 "Phosphorylation of L1 by ERK, Canis familiaris" xref: Reactome:REACT_85745 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_85751 "Phosphorylation of BRCA1 at multiple sites by ATM, Canis familiaris" xref: Reactome:REACT_85812 "Phosphorylation and activation of Chk1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_85836 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Gallus gallus" xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus" xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus" xref: Reactome:REACT_86033 "Phosphorylation and activation of CHK2 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_86061 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_86092 "Phosphorylation of COP1 at Ser-387 by ATM, Bos taurus" xref: Reactome:REACT_86211 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Saccharomyces cerevisiae" xref: Reactome:REACT_86252 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Drosophila melanogaster" xref: Reactome:REACT_86261 "Regulation of NUDC by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_86277 "Phosphorylation of TSC2 by PKB, Bos taurus" xref: Reactome:REACT_86365 "Phosphorylation and activation of eIF4G by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_86372 "Akt1 phosphorylates BAD protein, Mus musculus" xref: Reactome:REACT_86415 "Phosphorylation of Cx43 by c-src, Xenopus tropicalis" xref: Reactome:REACT_86422 "Phosphorylation of PD-1, Rattus norvegicus" xref: Reactome:REACT_86533 "Cdc6 protein is phosphorylated by CDK, Sus scrofa" xref: Reactome:REACT_86736 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_86800 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Danio rerio" xref: Reactome:REACT_86867 "Phosphorylation of p53 at ser-15 by ATM kinase, Bos taurus" xref: Reactome:REACT_86952 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Sus scrofa" xref: Reactome:REACT_86967 "Phosphorylation (Ser5) of RNA pol II CTD, Gallus gallus" xref: Reactome:REACT_87010 "Regulation of NUDC by phosphorylation, Danio rerio" xref: Reactome:REACT_87121 "Phosphorylation of cPLA2 by ERK-2, Bos taurus" xref: Reactome:REACT_87149 "Phosphorylation of L1 by CK-II, Danio rerio" xref: Reactome:REACT_87212 "Phosphorylation of Cx43 by c-src, Mus musculus" xref: Reactome:REACT_87222 "Cdc6 protein is phosphorylated by CDK, Schizosaccharomyces pombe" xref: Reactome:REACT_87298 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Sus scrofa" xref: Reactome:REACT_87329 "Regulation of KIF23 (MKLP1) by phosphorylation, Mus musculus" xref: Reactome:REACT_87391 "Phosphorylation of Cx43 by c-src, Rattus norvegicus" xref: Reactome:REACT_87424 "SOS phosphorylation and dissociation (SHC), Danio rerio" xref: Reactome:REACT_87437 "Phosphorylation of AKT2 by PDK1, Caenorhabditis elegans" xref: Reactome:REACT_87485 "Activation of S6K1, Xenopus tropicalis" xref: Reactome:REACT_87497 "Akt1 phosphorylates BAD protein, Bos taurus" xref: Reactome:REACT_87503 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_87523 "Phosphorylation of Cyclin B1 in the CRS domain, Mus musculus" xref: Reactome:REACT_87534 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Gallus gallus" xref: Reactome:REACT_87593 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Gallus gallus" xref: Reactome:REACT_87650 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_87679 "Phosphorylation of PDE3B, Xenopus tropicalis" xref: Reactome:REACT_87753 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_87880 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_87967 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Xenopus tropicalis" xref: Reactome:REACT_88025 "Activation of S6K1, Mus musculus" xref: Reactome:REACT_88055 "Phosphorylation of NBS1 by ATM, Sus scrofa" xref: Reactome:REACT_88091 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Xenopus tropicalis" xref: Reactome:REACT_88220 "Regulation of KIF23 (MKLP1) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_88298 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Taeniopygia guttata" xref: Reactome:REACT_88326 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_88374 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_88421 "Phosphorylation and inactivation of eEF2K by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_88430 "Orc1 is phosphorylated by cyclin A/CDK2, Bos taurus" xref: Reactome:REACT_88440 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_88458 "Phosphorylation of cPLA2 by ERK-2, Danio rerio" xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata" xref: Reactome:REACT_88516 "Cdc6 protein is phosphorylated by CDK, Rattus norvegicus" xref: Reactome:REACT_88548 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Taeniopygia guttata" xref: Reactome:REACT_88564 "Plk1-mediated phosphorylation of Nlp, Xenopus tropicalis" xref: Reactome:REACT_88590 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Rattus norvegicus" xref: Reactome:REACT_88665 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Danio rerio" xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster" xref: Reactome:REACT_88766 "Phosphorylation (Ser5) of RNA pol II CTD, Oryza sativa" xref: Reactome:REACT_88871 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Rattus norvegicus" xref: Reactome:REACT_88928 "Autophosphorylation of PAK-2p34 in the activation loop, Drosophila melanogaster" xref: Reactome:REACT_88987 "Free APC/C phosphorylated by Plk1, Canis familiaris" xref: Reactome:REACT_89001 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Gallus gallus" xref: Reactome:REACT_89026 "Phosphorylation of PD-1, Gallus gallus" xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris" xref: Reactome:REACT_89366 "Phosphorylation of APC component of the destruction complex, Canis familiaris" xref: Reactome:REACT_89427 "Phosphorylation of AKT2 by PDK1, Bos taurus" xref: Reactome:REACT_89464 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_89547 "Phosphorylation of NBS1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_89579 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_89769 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Taeniopygia guttata" xref: Reactome:REACT_89794 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Mus musculus" xref: Reactome:REACT_89879 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Mus musculus" xref: Reactome:REACT_89988 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_9007 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_90132 "Phosphorylation of AKT2 by PDK1, Sus scrofa" xref: Reactome:REACT_90167 "Phosphorylation of Wee1 kinase by Chk1, Bos taurus" xref: Reactome:REACT_90220 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_90227 "Phosphorylation of AKT2 by PDK1, Mus musculus" xref: Reactome:REACT_90290 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Taeniopygia guttata" xref: Reactome:REACT_90364 "Regulation of NUDC by phosphorylation, Canis familiaris" xref: Reactome:REACT_90426 "Phosphorylation of Wee1 kinase by Chk1, Mus musculus" xref: Reactome:REACT_90449 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Canis familiaris" xref: Reactome:REACT_90562 "Regulation of NUDC by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_9057 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Homo sapiens" xref: Reactome:REACT_9067 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Homo sapiens" xref: Reactome:REACT_90675 "Phosphorylation (Ser5) of RNA pol II CTD, Caenorhabditis elegans" xref: Reactome:REACT_907 "Mcm2-7 is phosphorylated by DDK, Homo sapiens" xref: Reactome:REACT_9070 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_908 "Phosphorylation of AKT2 by PDK1, Homo sapiens" xref: Reactome:REACT_90917 "Phosphorylation of Wee1 kinase by Chk1, Canis familiaris" xref: Reactome:REACT_91050 "SOS phosphorylation and dissociation (IRS, Crk), Mus musculus" xref: Reactome:REACT_91062 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio" xref: Reactome:REACT_91156 "Phosphorylation and activation of CHK2 by ATM, Gallus gallus" xref: Reactome:REACT_91157 "Phosphorylation (Ser5) of RNA pol II CTD, Saccharomyces cerevisiae" xref: Reactome:REACT_91196 "Phosphorylation of 4E-BP1 by activated mTORC1, Mus musculus" xref: Reactome:REACT_91197 "Phosphorylation and activation of eIF4B by activated S6K1, Mus musculus" xref: Reactome:REACT_91240 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Xenopus tropicalis" xref: Reactome:REACT_91263 "Down Regulation of Emi1 through Phosphorylation of Emi1, Gallus gallus" xref: Reactome:REACT_91382 "SOS phosphorylation and dissociation (IRS), Danio rerio" xref: Reactome:REACT_91470 "Regulation of KIF20A (MKL2) by phosphorylation, Canis familiaris" xref: Reactome:REACT_91501 "PIP2 conversion to PIP3, Bos taurus" xref: Reactome:REACT_91541 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_91574 "Phosphorylation of DLC2 by MAPK-8, Rattus norvegicus" xref: Reactome:REACT_91643 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Drosophila melanogaster" xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster" xref: Reactome:REACT_91760 "Regulation of KIF23 (MKLP1) by phosphorylation, Danio rerio" xref: Reactome:REACT_91937 "Phosphorylation of APC component of the destruction complex, Bos taurus" xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans" xref: Reactome:REACT_92108 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Rattus norvegicus" xref: Reactome:REACT_92126 "Activation of S6K1, Oryza sativa" xref: Reactome:REACT_92148 "Autophosphorylation of PAK-2p34 in the activation loop, Danio rerio" xref: Reactome:REACT_92219 "Phosphorylation of PDE3B, Caenorhabditis elegans" xref: Reactome:REACT_92247 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Canis familiaris" xref: Reactome:REACT_92407 "Regulation of KIF23 (MKLP1) by phosphorylation, Canis familiaris" xref: Reactome:REACT_92735 "Autophosphorylation of PAK-2p34 in the activation loop, Taeniopygia guttata" xref: Reactome:REACT_92736 "Phosphorylation of L1 by ERK, Gallus gallus" xref: Reactome:REACT_92804 "Phosphorylation of Wee1 kinase by Chk1, Danio rerio" xref: Reactome:REACT_92852 "SOS phosphorylation and dissociation (SHC), Canis familiaris" xref: Reactome:REACT_92889 "Phosphorylation of TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_92915 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Danio rerio" xref: Reactome:REACT_92929 "RAF1 phosphorylates MEK1, Danio rerio" xref: Reactome:REACT_92951 "Phosphorylation and activation of Chk1 by ATM, Canis familiaris" xref: Reactome:REACT_93018 "RAF1 phosphorylates MEK1, Bos taurus" xref: Reactome:REACT_93105 "Phosphorylation of cPLA2 by ERK-2, Rattus norvegicus" xref: Reactome:REACT_93124 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93149 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_93166 "Phosphorylation and activation of Chk1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_93219 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Xenopus tropicalis" xref: Reactome:REACT_93221 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_93346 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93366 "Phosphorylation of cPLA2 by ERK-2, Canis familiaris" xref: Reactome:REACT_93414 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_93440 "Regulation of KIF20A (MKL2) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_93441 "Regulation of KIF23 (MKLP1) by phosphorylation, Gallus gallus" xref: Reactome:REACT_93613 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_93615 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Bos taurus" xref: Reactome:REACT_937 "Phosphorylation of BRCA1 at multiple sites by ATM, Homo sapiens" xref: Reactome:REACT_93706 "RAF1 phosphorylates MEK1, Canis familiaris" xref: Reactome:REACT_93746 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Mus musculus" xref: Reactome:REACT_93878 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Gallus gallus" xref: Reactome:REACT_94017 "SOS phosphorylation and dissociation (IRS, Crk), Bos taurus" xref: Reactome:REACT_94113 "Phosphorylation of Cx43 by c-src, Canis familiaris" xref: Reactome:REACT_94151 "Phosphorylation of Wee1 kinase by Chk1, Xenopus tropicalis" xref: Reactome:REACT_94248 "SOS phosphorylation and dissociation (SHC), Bos taurus" xref: Reactome:REACT_94258 "Phosphorylation of p53 at ser-15 by ATM kinase, Sus scrofa" xref: Reactome:REACT_94298 "Phosphorylation of Cyclin B1 in the CRS domain, Danio rerio" xref: Reactome:REACT_94397 "Orc1 is phosphorylated by cyclin A/CDK2, Danio rerio" xref: Reactome:REACT_94428 "Phosphorylation of PD-1, Bos taurus" xref: Reactome:REACT_94452 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Bos taurus" xref: Reactome:REACT_94464 "Phosphorylation and activation of eIF4B by activated S6K1, Danio rerio" xref: Reactome:REACT_94562 "Phosphorylation of the Scc1:Cohesion Complex, Caenorhabditis elegans" xref: Reactome:REACT_94615 "SOS phosphorylation and dissociation (IRS, Crk), Rattus norvegicus" xref: Reactome:REACT_94784 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Rattus norvegicus" xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus" xref: Reactome:REACT_94947 "Autophosphorylation of PAK-2p34 in the activation loop, Canis familiaris" xref: Reactome:REACT_95052 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Oryza sativa" xref: Reactome:REACT_95087 "Phosphorylation of the Scc1:Cohesion Complex, Bos taurus" xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus" xref: Reactome:REACT_95089 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Bos taurus" xref: Reactome:REACT_95155 "Regulation of NUDC by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_95163 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_95437 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_95461 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Bos taurus" xref: Reactome:REACT_95504 "Phosphorylation of Cdc25C at Ser216, Xenopus tropicalis" xref: Reactome:REACT_95769 "PIP2 conversion to PIP3, Xenopus tropicalis" xref: Reactome:REACT_96 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Homo sapiens" xref: Reactome:REACT_96039 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Canis familiaris" xref: Reactome:REACT_96088 "Phosphorylation of PDE3B, Sus scrofa" xref: Reactome:REACT_96097 "SOS phosphorylation and dissociation (IRS), Rattus norvegicus" xref: Reactome:REACT_96102 "Phosphorylation of Cx43 by c-src, Gallus gallus" xref: Reactome:REACT_96129 "Phosphorylation and activation of eIF4G by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_96200 "Regulation of NUDC by phosphorylation, Gallus gallus" xref: Reactome:REACT_96208 "Phosphorylation of COP1 at Ser-387 by ATM, Sus scrofa" xref: Reactome:REACT_96218 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_96356 "Free APC/C phosphorylated by Plk1, Rattus norvegicus" xref: Reactome:REACT_96461 "Phosphorylation of L1 by CK-II, Bos taurus" xref: Reactome:REACT_96468 "Autophosphorylation of PAK-2p34 in the activation loop, Mus musculus" xref: Reactome:REACT_96483 "Phosphorylation of COP1 at Ser-387 by ATM, Gallus gallus" xref: Reactome:REACT_96500 "RAF1 phosphorylates MEK2, Gallus gallus" xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis" xref: Reactome:REACT_96656 "Plk1-mediated phosphorylation of Nlp, Rattus norvegicus" xref: Reactome:REACT_96666 "Phosphorylation and activation of CHK2 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_96758 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Canis familiaris" xref: Reactome:REACT_96793 "Activation of S6K1, Danio rerio" xref: Reactome:REACT_96797 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Rattus norvegicus" xref: Reactome:REACT_96877 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Sus scrofa" xref: Reactome:REACT_96899 "Phosphorylation of TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_96968 "Cdc6 protein is phosphorylated by CDK, Mus musculus" xref: Reactome:REACT_97193 "Phosphorylation and activation of eIF4G by activated S6K1, Canis familiaris" xref: Reactome:REACT_97218 "Orc1 is phosphorylated by cyclin A/CDK2, Xenopus tropicalis" xref: Reactome:REACT_97282 "Activation of S6K1, Sus scrofa" xref: Reactome:REACT_97299 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_97458 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Dictyostelium discoideum" xref: Reactome:REACT_97577 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Bos taurus" xref: Reactome:REACT_97661 "Mcm2-7 is phosphorylated by DDK, Gallus gallus" xref: Reactome:REACT_97667 "Phosphorylation of complexed TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_97748 "Phosphorylation of cPLA2 by ERK-2, Mus musculus" xref: Reactome:REACT_97759 "Phosphorylation of Cx43 by c-src, Danio rerio" xref: Reactome:REACT_97847 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Mus musculus" xref: Reactome:REACT_97905 "Phosphorylation of BRCA1 at multiple sites by ATM, Xenopus tropicalis" xref: Reactome:REACT_98024 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Mus musculus" xref: Reactome:REACT_98050 "Phosphorylation of Cdc25C at Ser216, Canis familiaris" xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_98109 "Regulation of NUDC by phosphorylation, Mus musculus" xref: Reactome:REACT_98176 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Bos taurus" xref: Reactome:REACT_98213 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Xenopus tropicalis" xref: Reactome:REACT_98253 "RAF1 phosphorylates MEK2, Bos taurus" xref: Reactome:REACT_98296 "Phosphorylation of Cyclin B1 in the CRS domain, Drosophila melanogaster" xref: Reactome:REACT_98373 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Drosophila melanogaster" xref: Reactome:REACT_98378 "Phosphorylation of COP1 at Ser-387 by ATM, Danio rerio" xref: Reactome:REACT_98395 "Phosphorylation and activation of Chk1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_98434 "Phosphorylation and inactivation of eEF2K by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_98436 "Phosphorylation of 4E-BP1 by activated mTORC1, Gallus gallus" xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus" xref: Reactome:REACT_98493 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Drosophila melanogaster" xref: Reactome:REACT_98558 "Autophosphorylation of PAK-2p34 in the activation loop, Saccharomyces cerevisiae" xref: Reactome:REACT_98560 "Phosphorylation and activation of CHK2 by ATM, Xenopus tropicalis" xref: Reactome:REACT_98663 "Regulation of KIF23 (MKLP1) by phosphorylation, Bos taurus" xref: Reactome:REACT_98708 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_98731 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Danio rerio" xref: Reactome:REACT_98738 "Phosphorylation of TSC2 by PKB, Danio rerio" xref: Reactome:REACT_98741 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Bos taurus" xref: Reactome:REACT_98779 "Phosphorylation of Cx43 by c-src, Taeniopygia guttata" xref: Reactome:REACT_988 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Homo sapiens" xref: Reactome:REACT_98847 "Phosphorylation of complexed TSC2 by PKB, Mus musculus" xref: Reactome:REACT_98908 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_98913 "Phosphorylation of PD-1, Canis familiaris" xref: Reactome:REACT_98971 "Phosphorylation of AKT2 by PDK1, Rattus norvegicus" xref: Reactome:REACT_98996 "Free APC/C phosphorylated by Plk1, Danio rerio" xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata" xref: Reactome:REACT_99053 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Sus scrofa" xref: Reactome:REACT_99141 "Phosphorylation of NBS1 by ATM, Bos taurus" xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster" xref: Reactome:REACT_99207 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_99231 "Phosphorylation of AKT2 by PDK1, Danio rerio" xref: Reactome:REACT_99266 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Caenorhabditis elegans" xref: Reactome:REACT_99302 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Sus scrofa" xref: Reactome:REACT_99311 "RAF1 phosphorylates MEK1, Mus musculus" xref: Reactome:REACT_9955 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Homo sapiens" xref: Reactome:REACT_99556 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Mus musculus" xref: Reactome:REACT_99560 "RAF1 phosphorylates MEK2, Canis familiaris" xref: Reactome:REACT_9959 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Homo sapiens" xref: Reactome:REACT_99595 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Bos taurus" xref: Reactome:REACT_99713 "Phosphorylation of DLC2 by MAPK-8, Taeniopygia guttata" xref: Reactome:REACT_9978 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Homo sapiens" xref: Reactome:REACT_99785 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Canis familiaris" xref: Reactome:REACT_9983 "Phosphorylation of APC component of the destruction complex, Homo sapiens" xref: Reactome:REACT_9987 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Homo sapiens" xref: Reactome:REACT_99929 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Gallus gallus" xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_9997 "Phosphorylation of Cx43 by c-src, Homo sapiens" is_a: GO:0016740 ! transferase activity relationship: part_of GO:0016310 ! phosphorylation [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0016469 name: proton-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] subset: goslim_metagenomics subset: goslim_pir synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:REACT_102858 "Diiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_102973 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris" xref: Reactome:REACT_103874 "Monoiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_104604 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio" xref: Reactome:REACT_105062 "Monoiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_105121 "Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_106088 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus" xref: Reactome:REACT_106276 "Monoiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_107002 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa" xref: Reactome:REACT_107467 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus" xref: Reactome:REACT_108745 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata" xref: Reactome:REACT_109500 "Monoiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_110582 "Diiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_115316 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Drosophila melanogaster" xref: Reactome:REACT_15389 "Monoiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_15410 "Diiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_17006 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens" xref: Reactome:REACT_17042 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens" xref: Reactome:REACT_29212 "Diiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_30160 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus" xref: Reactome:REACT_31762 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus" xref: Reactome:REACT_32960 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus" xref: Reactome:REACT_34705 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus" xref: Reactome:REACT_44470 "Monoiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_78923 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata" xref: Reactome:REACT_84842 "Diiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_86178 "Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_88304 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus" xref: Reactome:REACT_89057 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus" xref: Reactome:REACT_90394 "Diiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_91638 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana" xref: Reactome:REACT_91952 "Monoiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_92075 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis" xref: Reactome:REACT_92434 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris" xref: Reactome:REACT_93539 "Diiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_93974 "Diiodinated tyrosine can be deiodinated, Taeniopygia guttata" xref: Reactome:REACT_95169 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio" xref: Reactome:REACT_95558 "Monoiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_95573 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans" xref: Reactome:REACT_97234 "Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_97568 "Diiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_97851 "Diiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_98022 "Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_99085 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa" xref: Reactome:REACT_99794 "Diiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_99989 "Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata" is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0043167 ! ion binding [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2 xref: Reactome:REACT_25050 "Molybdenum ion transfer onto molybdopterin, Homo sapiens" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3 xref: Reactome:REACT_110436 "Hydrolysis of phosphatidylcholine, Bos taurus" xref: Reactome:REACT_111159 "Partial proteolysis of antigen in phagolysosomes, Homo sapiens" xref: Reactome:REACT_15331 "Hydrolysis of phosphatidylcholine, Homo sapiens" xref: Reactome:REACT_83734 "Hydrolysis of phosphatidylcholine, Danio rerio" xref: Reactome:REACT_84047 "Hydrolysis of phosphatidylcholine, Xenopus tropicalis" xref: Reactome:REACT_87959 "Hydrolysis of phosphatidylcholine, Gallus gallus" xref: Reactome:REACT_88159 "Hydrolysis of phosphatidylcholine, Canis familiaris" xref: Reactome:REACT_90118 "Hydrolysis of phosphatidylcholine, Mus musculus" xref: Reactome:REACT_91045 "Hydrolysis of phosphatidylcholine, Taeniopygia guttata" xref: Reactome:REACT_98572 "Hydrolysis of phosphatidylcholine, Rattus norvegicus" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: RHEA:21664 is_a: GO:0016787 ! hydrolase activity relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other lyase activity" NARROW [] xref: EC:4 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 xref: Reactome:REACT_115603 "Ligation of DNA at sites of patch replacement, Gallus gallus" xref: Reactome:REACT_116018 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0017000 name: antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] subset: goslim_metagenomics synonym: "antibiotic anabolism" EXACT [] synonym: "antibiotic biosynthesis" EXACT [] synonym: "antibiotic formation" EXACT [] synonym: "antibiotic synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0017004 name: cytochrome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] subset: goslim_metagenomics synonym: "cytochrome biogenesis" BROAD [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: RHEA:23680 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019008 name: molybdopterin synthase complex namespace: cellular_component alt_id: GO:0019009 def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] subset: goslim_metagenomics synonym: "molybdopterin converting factor complex" EXACT [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0019012 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019842 name: vitamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019898 name: extrinsic component of membrane namespace: cellular_component alt_id: GO:0030396 def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. subset: goslim_metagenomics synonym: "extrinsic to membrane" EXACT [] synonym: "peripheral membrane protein" EXACT [] xref: Wikipedia:Peripheral_membrane_protein is_a: GO:0005575 ! cellular_component relationship: part_of GO:0016020 ! membrane [Term] id: GO:0030170 name: pyridoxal phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] subset: goslim_metagenomics is_a: GO:0019842 ! vitamin binding is_a: GO:0043167 ! ion binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0031224 name: intrinsic component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: goslim_metagenomics synonym: "intrinsic to membrane" NARROW [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0016020 ! membrane [Term] id: GO:0033202 name: DNA helicase complex namespace: cellular_component def: "A protein complex that possesses DNA helicase activity." [GOC:mah] subset: goslim_metagenomics subset: goslim_pir is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function alt_id: GO:0004872 alt_id: GO:0019041 def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] is_a: GO:0003674 ! molecular_function created_by: rfoulger creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042575 name: DNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] subset: goslim_metagenomics subset: goslim_pir is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0042597 name: periplasmic space namespace: cellular_component alt_id: GO:0005620 def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] subset: goslim_metagenomics subset: goslim_pir synonym: "periplasm" EXACT [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005575 ! cellular_component [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0043190 name: ATP-binding cassette (ABC) transporter complex namespace: cellular_component alt_id: GO:0043191 alt_id: GO:0043192 def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] subset: goslim_metagenomics subset: goslim_pir synonym: "ABC-type efflux permease complex" NARROW [] synonym: "ABC-type efflux porter complex" NARROW [] synonym: "ABC-type uptake permease complex" NARROW [] synonym: "ATP-binding cassette (ABC) transporter complex" RELATED [] synonym: "mating pheromone exporter" NARROW [] is_a: GO:0098796 ! membrane protein complex is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0031224 ! intrinsic component of membrane [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0008150 ! biological_process [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] xref: Reactome:REACT_111217 "Metabolism, Homo sapiens" xref: Reactome:REACT_112077 "Metabolism, Xenopus tropicalis" xref: Reactome:REACT_112140 "Metabolism, Dictyostelium discoideum" xref: Reactome:REACT_112621 "Metabolism, Mus musculus" xref: Reactome:REACT_112912 "Metabolism, Arabidopsis thaliana" xref: Reactome:REACT_113131 "Metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_113305 "Metabolism, Canis familiaris" xref: Reactome:REACT_113457 "Metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_113568 "Metabolism, Rattus norvegicus" xref: Reactome:REACT_113610 "Metabolism, Caenorhabditis elegans" xref: Reactome:REACT_113934 "Metabolism, Escherichia coli" xref: Reactome:REACT_114081 "Metabolism, Gallus gallus" xref: Reactome:REACT_114137 "Metabolism, Sus scrofa" xref: Reactome:REACT_114421 "Metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_114473 "Metabolism, Danio rerio" xref: Reactome:REACT_114495 "Metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_114668 "Metabolism, Plasmodium falciparum" xref: Reactome:REACT_114983 "Metabolism, Drosophila melanogaster" xref: Reactome:REACT_115063 "Metabolism, Taeniopygia guttata" xref: Reactome:REACT_115388 "Metabolism, Oryza sativa" xref: Reactome:REACT_115420 "Metabolism, Bos taurus" xref: Reactome:REACT_115655 "Metabolism, Gallus gallus" is_a: GO:0008152 ! metabolic process created_by: jane creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0045454 name: cell redox homeostasis namespace: biological_process alt_id: GO:0030503 alt_id: GO:0045867 alt_id: GO:0045868 def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_metagenomics synonym: "regulation of cell redox homeostasis" RELATED [] synonym: "regulation of redox homeostasis" BROAD [] is_a: GO:0008150 ! biological_process relationship: occurs_in GO:0005575 ! cellular_component relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0046718 name: viral entry into host cell namespace: biological_process alt_id: GO:0019063 def: "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl] comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location. subset: goslim_metagenomics synonym: "entry of virus into host cell" EXACT [] synonym: "phage translocation" EXACT [] synonym: "viral penetration" EXACT [] synonym: "virion penetration" EXACT [] synonym: "virion penetration into host cell" EXACT [] synonym: "virus entry into host cell" EXACT [GOC:bf] xref: Reactome:REACT_6232 "Binding of the influenza virion to the host cell, Homo sapiens" xref: Reactome:REACT_6282 "Fusion and Uncoating of the Influenza Virion, Homo sapiens" xref: VZ:936 is_a: GO:0008150 ! biological_process relationship: part_of GO:0016032 ! viral process [Term] id: GO:0046872 name: metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any metal ion." [GOC:ai] subset: goslim_agr subset: goslim_metagenomics synonym: "heavy metal binding" NARROW [] synonym: "metal binding" EXACT [] is_a: GO:0043167 ! ion binding [Term] id: GO:0046906 name: tetrapyrrole binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [CHEBI:26932, GOC:curators, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "porphyrin binding" NARROW [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0048500 name: signal recognition particle namespace: cellular_component def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] subset: goslim_metagenomics subset: goslim_pir xref: Wikipedia:Signal_recognition_particle is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0050662 name: coenzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] subset: goslim_metagenomics is_a: GO:0003674 ! molecular_function [Term] id: GO:0051536 name: iron-sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] subset: goslim_metagenomics synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0071840 ! cellular component organization or biogenesis relationship: part_of GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0071103 name: DNA conformation change namespace: biological_process def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] subset: goslim_metagenomics synonym: "DNA conformation modification" EXACT [GOC:mah] is_a: GO:0071840 ! cellular component organization or biogenesis created_by: midori creation_date: 2009-11-09T11:36:34Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0008150 ! biological_process created_by: midori creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071973 name: bacterial-type flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:krc, GOC:mah] subset: goslim_metagenomics synonym: "bacterial-type flagellar cell motility" RELATED [] synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process created_by: midori creation_date: 2010-10-21T12:00:53Z [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0005575 ! cellular_component relationship: part_of GO:0016020 ! membrane [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] subset: goslim_metagenomics synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: GO:0005575 ! cellular_component created_by: bhm creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1990204 name: oxidoreductase complex namespace: cellular_component def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] subset: goslim_metagenomics synonym: "oxidation-reduction complex" EXACT [] synonym: "redox complex" EXACT [] is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005575 ! cellular_component created_by: bhm creation_date: 2013-10-07T08:24:47Z [Typedef] id: ends_during name: ends_during namespace: external xref: RO:0002093 [Typedef] id: happens_during name: happens_during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_part name: has_part namespace: external xref: BFO:0000051 is_transitive: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: never_in_taxon name: never_in_taxon namespace: external xref: RO:0002161 expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" [] is_metadata_tag: true is_class_level: true [Typedef] id: occurs_in name: occurs in namespace: external xref: BFO:0000066 holds_over_chain: part_of occurs_in transitive_over: part_of ! part of [Typedef] id: part_of name: part of namespace: external xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has_part [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 holds_over_chain: negatively_regulates negatively_regulates is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 is_transitive: true transitive_over: part_of ! part of [Typedef] id: starts_during name: starts_during namespace: external xref: RO:0002091