Universal Protein Resource (UniProt)
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The Universal Protein Resource (UniProt), a collaboration between the European
Bioinformatics Institute (EBI), the SIB Swiss Institute of Bioinformatics, and
the Protein Information Resource (PIR), is comprised of three databases, each
optimized for different uses. The UniProt Knowledgebase (UniProtKB) is the
central access point for extensively curated protein information, including
function, classification and cross-references. The UniProt Reference Clusters
(UniRef) combine closely related sequences into a single record to speed up
sequence similarity searches. The UniProt Archive (UniParc) is a comprehensive
repository of all protein sequences, consisting only of unique identifiers and
sequences.


UniParc
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The UniProt Archive (UniParc) is a non-redundant protein sequence archive,
containing all new and revised protein sequences from all publicly available 
sources (http://www.uniprot.org/help/uniparc) to ensure that complete sequence 
coverage is available at a single site. To avoid redundancy, all sequences 
100% identical over the entire length are merged, regardless of the source organism. 
New and updated sequences are cross-referenced to the source database accession 
number, and provided with a sequence version that increments upon changes to the 
underlying sequence. The basic information stored within each UniParc entry is 
the identifier, the sequence, cyclic redundancy check number, source database(s) 
with accession and version numbers, and a time stamp. If a UniParc entry lacks a 
cross-reference to a UniProtKB entry, the reason for its exclusion from UniProtKB 
is provided (e.g. pseudogene). In addition, each source database accession number 
is tagged with its status in that database, indicating if the sequence still exists 
or has been deleted in the source database and cross-references to NCBI GI and 
TaxId if appropriate.


This directory contains the following files:


uniparc_active.fasta.gz   UniParc sequences with active cross-references to the source database.

uniparc_all.xml.gz        All UniParc sequences including those that have been deleted from the source database.
                          It also includes:
                          - cross-references to the source databases
                          - status of the sequence in the source database 
                            (e.g. if the sequence still exist the status will be "active")
                          - source database accessions and version numbers
                          - if the sequence is not in UniProtKB, the reason for its exclusion
                          - cross-references to NCBI GI and TaxID if appropiate

uniparc.xsd               Schema definition for the UniParc XML

These files are updated with each UniProt release.


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(CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) to all
copyrightable parts of our databases.

(c) 2002-2021 UniProt Consortium

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Any medical or genetic information is provided for research, educational and
informational purposes only. It is not in any way intended to be used as a
substitute for professional medical advice, diagnosis, treatment or care.