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<entry dataset="TrEMBL" created="2018-02-28" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2H4X1S4</accession>
    <name>A0A2H4X1S4_9VIRU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Replicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Transcriptase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Vinegar Hill virus</name>
        <dbReference type="NCBI Taxonomy" id="2059308"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Polyploviricotina</taxon>
            <taxon>Ellioviricetes</taxon>
            <taxon>Bunyavirales</taxon>
            <taxon>Nairoviridae</taxon>
            <taxon>Orthonairovirus</taxon>
            <taxon>Vinegar Hill orthonairovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="Viruses" volume="9" first="E373" last="E373">
            <title>Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets.</title>
            <authorList>
                <person name="Gauci P.J."/>
                <person name="McAllister J."/>
                <person name="Mitchell I.R."/>
                <person name="Cybinski D."/>
                <person name="St George T."/>
                <person name="Gubala A.J."/>
            </authorList>
            <dbReference type="PubMed" id="29206186"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CS1499</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MF176881">
        <property type="protein sequence ID" value="AUD40046.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680064">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039694">
        <property type="term" value="P:viral RNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007099">
        <property type="entry name" value="RNA-dir_pol_NSvirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007322">
        <property type="entry name" value="RNA_pol_bunyavir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04196">
        <property type="entry name" value="Bunya_RdRp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50525">
        <property type="entry name" value="RDRP_SSRNA_NEG_SEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="6">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RdRp catalytic" evidence="5">
        <location>
            <begin position="2341"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2707"/>
            <end position="2745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3920"/>
            <end position="3948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2722"/>
            <end position="2745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AUD40046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000680064"/>
        </source>
    </evidence>
    <sequence length="3948" mass="447733" checksum="716335A097E58F08" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2H4X1W2</accession>
    <name>A0A2H4X1W2_9VIRU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">M polyprotein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Vinegar Hill virus</name>
        <dbReference type="NCBI Taxonomy" id="2059308"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Polyploviricotina</taxon>
            <taxon>Ellioviricetes</taxon>
            <taxon>Bunyavirales</taxon>
            <taxon>Nairoviridae</taxon>
            <taxon>Orthonairovirus</taxon>
            <taxon>Vinegar Hill orthonairovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Viruses" volume="9" first="E373" last="E373">
            <title>Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets.</title>
            <authorList>
                <person name="Gauci P.J."/>
                <person name="McAllister J."/>
                <person name="Mitchell I.R."/>
                <person name="Cybinski D."/>
                <person name="St George T."/>
                <person name="Gubala A.J."/>
            </authorList>
            <dbReference type="PubMed" id="29206186"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CS1499</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="MF176882">
        <property type="protein sequence ID" value="AUD40047.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680064">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044178">
        <property type="term" value="C:host cell Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002532">
        <property type="entry name" value="Hanta_Gc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012487">
        <property type="entry name" value="Nairovirus_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01561">
        <property type="entry name" value="Hanta_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07948">
        <property type="entry name" value="Nairovirus_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="Hanta_G2" evidence="8">
        <location>
            <begin position="824"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AUD40047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000680064"/>
        </source>
    </evidence>
    <sequence length="1414" mass="159452" checksum="0ED1D0E3384DAED5" modified="2018-02-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-02-28" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2H4X1X3</accession>
    <name>A0A2H4X1X3_9VIRU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleocapsid protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Vinegar Hill virus</name>
        <dbReference type="NCBI Taxonomy" id="2059308"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Polyploviricotina</taxon>
            <taxon>Ellioviricetes</taxon>
            <taxon>Bunyavirales</taxon>
            <taxon>Nairoviridae</taxon>
            <taxon>Orthonairovirus</taxon>
            <taxon>Vinegar Hill orthonairovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="Viruses" volume="9" first="E373" last="E373">
            <title>Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets.</title>
            <authorList>
                <person name="Gauci P.J."/>
                <person name="McAllister J."/>
                <person name="Mitchell I.R."/>
                <person name="Cybinski D."/>
                <person name="St George T."/>
                <person name="Gubala A.J."/>
            </authorList>
            <dbReference type="PubMed" id="29206186"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CS1499</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nairovirus nucleocapsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MF176883">
        <property type="protein sequence ID" value="AUD40048.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680064">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019029">
        <property type="term" value="C:helical viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019013">
        <property type="term" value="C:viral nucleocapsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003486">
        <property type="entry name" value="Nairo_nucleocap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02477">
        <property type="entry name" value="Nairo_nucleo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1139">Helical capsid protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AUD40048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000680064"/>
        </source>
    </evidence>
    <sequence length="499" mass="56308" checksum="F871A12AD790763D" modified="2018-02-28" version="1">MAGYGFELDFPSEKEWNDWYKAYSNKHPILNSMHTNFDSFMTVMPDLGDFKQEMARHKDDPRGLKDSIFGKAVLKLTEHAAPIKECAWLVNKTFVTDALQWFENNKDKDYVKVWDSKYTTLMSELPSLDQVKAYQHAALKFRKSVLLPKTQAFKTLDGEVLVEYKVSKSLIASIFDMLKDMENKRSAQRNPSGGQPTDRKEAIDNNSKWMANWINSKDALLDMPPWGPWDKKTSKGYPIALTSLIKFEQTYKVDVSDVLDTKVKQLYQILNLKKDEAEDFDLDAVKIIVNTLELFEPLKRSLKAEAESNAGPGFGQQAAALDTVFSSCYWLWKSGVSLQSFPALSKFLHELGSKVVGKTKLSSVLKSCGWKWGKGLLGIMSIGTFTGNRMHMHPAVLTAGRMSSDMVLSFGSVPAYDADLAREPTGSIRSILNLETNRKNSCADGIVRLWNVFCAGYTYEDEDIIPPEHMLHQSFLGKISPFQNVSKLEGDALKVRIKS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>