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                <person name="Duan Y."/>
                <person name="White R.C."/>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
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                <person name="Schnabl B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005335">
        <property type="entry name" value="Terminase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03592">
        <property type="entry name" value="Terminase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="211" mass="24081" checksum="BCC8467DB92234D1" modified="2019-07-03" version="1">MSLNKYSRKEEALMVRIGNRELEERQRKYLTTSKEPDEYEGVDLTTLKPKMKRFARHYMQTMNIAESCRSVGYNESSGYRVLKREDVKAYLQWLVSENADAAIMSPTQVLEELTNIALRNSSDYTVTVKGDVVEKPIDTSVQLSALNSLAKFHDLLAPDVKVEQSLNIVVDIADDVPNEAEEVEEEEFVEGDFTEVEEEDSDVSYDFLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS82</accession>
    <name>A0A4D6DS82_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="86" mass="9852" checksum="CC3199906C72B7B1" modified="2019-07-03" version="1">MNRIKVYTKDMCQACKMAKRVLTEGGVSFDEVFVDIRNDTETVEMLRLAGFRSFPVVMLDEDYDTAISGFHPPRLKAFIETVKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS83</accession>
    <name>A0A4D6DS83_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tail length tape-measure protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="135"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="961" mass="101584" checksum="5A53BC4971282074" modified="2019-07-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS86</accession>
    <name>A0A4D6DS86_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="145" mass="14991" checksum="B97D2BE505923FDA" modified="2019-07-03" version="1">MAKTYNIYQDGVKVQEGIAELTKTITGLTPNTSYKFEVTAVEDGVESAKSTEVTAKTNPRKVATVTASQKTMSLASDGSKALTFTVAPEDATNKELEITNSNPEFATYADGTVTAVAEGTTTITATAKDGSGATANCVVTVQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS87</accession>
    <name>A0A4D6DS87_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="125" mass="14796" checksum="CE42FE5EF3D36B4F" modified="2019-07-03" version="1">MRYNDIVDLIQFNDWEDPDDDYGTISYKTRGTIVVKDLPVSVGSLRVQGKLLQNQDQQWEKRYLIQHKVFELKNLRVDAVRRHSTGEILNVYWDNTTGTDQTVSYKVEYRDIRRDKEDGVIWQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS88</accession>
    <name>A0A4D6DS88_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="82" mass="8352" checksum="FDD58FF833AFCB6D" modified="2019-07-03" version="1">MDVVISIAVVLGGVTTGLVNLVKSMDVVPPKYLPLVSLAIGMVFGLAMSPLLGITLYVGAISGLVAGLSAMGFYELTKTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS92</accession>
    <name>A0A4D6DS92_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="66" mass="7383" checksum="C5A8C8E824B81A82" modified="2019-07-03" version="1">MDYSKFKIGDTVMYQGQLCGAGTVINGNTYTVVQLTTKPRHAFIIDEHGNKKLIQMGFNFAKIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS93</accession>
    <name>A0A4D6DS93_9CAUD</name>
    <protein>
        <submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
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        <lineage>
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            <taxon>Duplodnaviria</taxon>
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            <taxon>Caudovirales</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="251" mass="28698" checksum="B5EFA7213090B77A" modified="2019-07-03" version="1">MARKKDKEKRQQEIEDALVALMTAQNHKYHRFTDRFTVLLDGFVNELIVNLADPKLDAFAILQVSQYEAIRKLQAALIDYQEEFREMLLESMSDTLEETLGQLFPNKAIPSATDNAYIEQVIAEAYDYFEEIFLQLLVEIEAIAVGTIPSTEDIVTTIQKLRDRLSYTLRRHIEAQMSAVINLAVIEASKQYEIELWKWCIRPELTESGTCADCRELAEGGIGNEGLYTLATMPLLPRHPHCVCILIPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS95</accession>
    <name>A0A4D6DS95_9CAUD</name>
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            <taxon>unclassified Saphexavirus</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tail" evidence="2">
        <location>
            <begin position="117"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QBZ69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="1101" mass="121234" checksum="FD40B3A4AEC08A5D" modified="2019-07-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS97</accession>
    <name>A0A4D6DS97_9CAUD</name>
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        </submittedName>
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            <taxon>Caudovirales</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
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    </evidence>
    <sequence length="143" mass="16247" checksum="6207EB08C8F86DF1" modified="2019-07-03" version="1">MSNRPPFRARSSSVALQRAIVKEIRAQGINVWDGTNKFPEYPFIKIGEELTSGRTISKDAIGKMHNLTLHIWSDYDSSFEVKSLTDFLVDLLINSPLNLEDGFCIGEKSLDHVRYTEAANGTYKNERAYLFLDFEVIDSTIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="77" mass="8906" checksum="9363A81BD62CF70C" modified="2019-07-03" version="1">MELTREVGTFWKYPDNLLHFLIMGTVGGKYQVVYFDSFDSQCYYAEMSESQTESFVPSCDWEINKTLIEELSKGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSA1</accession>
    <name>A0A4D6DSA1_9CAUD</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="74" mass="8727" checksum="7068EFFA278ACD01" modified="2019-07-03" version="1">MLRGAYQRQSREASLFLSLVQSKKPVKLEKYQGFELVNETNKPKTTRDMAETMDELDRAAFKEEELSNLFDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSA2</accession>
    <name>A0A4D6DSA2_9CAUD</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69243.1"/>
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        <source>
            <dbReference type="EMBL" id="QBZ69243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="113" mass="12781" checksum="8144E2982FF1EBA1" modified="2019-07-03" version="1">MKSLGISKVNYVCRHYGGTVLEDEVVEIVGEWTSALGDHIMEVLPMDSESREETVVIKAYNIHRMSPEEVLDYHLNNLECDLLANADYGGEPFTEAYVDGYLKALKDIKEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSA6</accession>
    <name>A0A4D6DSA6_9CAUD</name>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="79" mass="8978" checksum="6871475CB944D3F9" modified="2019-07-03" version="1">MSWKVGLNDCKVVFSEEFKNGWEVHVVHSLNGFGHMYVENKPYSVAVSKPSDDFSDYFTVGTAEKVIAVIDEVRGYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSA8</accession>
    <name>A0A4D6DSA8_9CAUD</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="QBZ69261.1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="59" mass="6666" checksum="DB470FA8BA432A30" modified="2019-07-03" version="1">MDNSLSVYEVQILNTNTGCLDVFLVTAISITFAYINFSEIFEEDFHDDGNVKVVKLEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSA9</accession>
    <name>A0A4D6DSA9_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="47" mass="5270" checksum="A8AA5406F1470E31" modified="2019-07-03" version="1">MHNFYKAVSKATGRSPLGCEETSERLSTILYAIALLKPKDLTVLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB1</accession>
    <name>A0A4D6DSB1_9CAUD</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="125" mass="14163" checksum="27A06B030CE5917F" modified="2019-07-03" version="1">MERLMVVTKIISDPSVKLFEPQSIELVDNFYEDDFPEGDMLKEAVSESLWNAAYEILHTQMAMADKVIALVTVYNASTLEESTYAYEAIQDSVNKAICGGAVEDVKWKQFVGSLDSDYKEFFEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB2</accession>
    <name>A0A4D6DSB2_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="150" mass="17499" checksum="3CA6E17C16BFB045" modified="2019-07-03" version="1">MTATKELWKPLVFKGIHSDIYEVSSEGLVKNKLTDRLLKPQDSGYLHVRIPLEGKYYNARIHRIVAETFCERPAGCNVVNHINGNKKDNRASNLEWITQRDNVIHSLKLREEESKNLSIIEKMDMLLEKLIPSPEAKYNFMEEYVEWLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB4</accession>
    <name>A0A4D6DSB4_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="112" mass="13249" checksum="3A86FF679A367F57" modified="2019-07-03" version="1">MKESIYSDIPELDLKPDVYGVLFNFYCDKCQKPIVMRLDKYNMELLDDAYFRHSDSIVRVILEDCMSGYRVALDLRDVVTYTSKKLDREDFDFSWRAFTDWVDAFTDNEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB6</accession>
    <name>A0A4D6DSB6_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="62" mass="7066" checksum="CD129D88FDE35577" modified="2019-07-03" version="1">METMYTVIYKNAVESEPALEGGSFLTDAPKTDGLKLMTFGTRVFEIEFIDKAEKKIYATRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB7</accession>
    <name>A0A4D6DSB7_9CAUD</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="71" mass="8264" checksum="D9E49EBF854D845A" modified="2019-07-03" version="1">MEIKVEQLEEILLDVGWRHTSDWIVTVSTVSVKDTECAYENACYKVLEEICEFIDSEYIDICFVREAVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSB9</accession>
    <name>A0A4D6DSB9_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="65" mass="7200" checksum="070BE90793FF3A99" modified="2019-07-03" version="1">MELLRRIIYSLLVALLVVLLMGIFFAGFYWLLAITKPLGELGVLITLGAIVFVSVALGIFFIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSC2</accession>
    <name>A0A4D6DSC2_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="454" mass="50777" checksum="6438775133C11F8F" modified="2019-07-03" version="1">MASITAEMLLSKVINENDVQALNRHGVSEDLFQSPIHKDAYNFIIKFSRENEGNAPSYQTLLQKVPELDYQSSTEESFTSLTKSLKNSRLQVDTAAFINKDLGEFWENSVKSDDPTEFINQTIAALEQIKAEHNVGGASGRRLEKASEWYLEEFYKRKEGLSVKFWDSHFESLTELIGGGYQSGNVYTWYGRSGRGKSTITLVEAIEAAVQGANVLMWVLEMPKYEFASRAISFISARDEVKKSRINGSDYLAGFNIANLTQATFDTAEEEQDFVDFINSLNDKLEGSITIRAVDDEDFMNRSLKQLERDIVENGADVVVIDPFYYLHYEKNTSKTAGGDASQTSKALRLLAGRTKTVIHAITQAEEDSNEKGGDERELNIPKRSNVKKTMSLLEDAAYVLAFDSCDSRFAVEVVKGRSGNEGKQVEGIFLPVIGYVEESSDEAVTDVFEGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSC4</accession>
    <name>A0A4D6DSC4_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="69" mass="7864" checksum="F7E66BEEA76E8531" modified="2019-07-03" version="1">MIELFKENLTLDEMSEIWCGWDNEGLLYGWENGEAGEAYALLYEKGYNMDSIKVLHEAFDTIGELIGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSC6</accession>
    <name>A0A4D6DSC6_9CAUD</name>
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            <taxon>Duplodnaviria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="189" mass="21391" checksum="539D0D4F6F5C18B7" modified="2019-07-03" version="1">MKQQLRIAITGTSRAGKDTFAQAIQKKLVEMGFAEAMPIAFADPLKQLYKRYFFYMEDKEKPRDAYVTIGNAMREVDENVWINSLLLQAAKDWDEGFSTLVTDVRFENEAKTLINDYGFILVKVDADPLIRLGRAEALGETLDLNNKGDIEVGMIEPHLTFLNNGESDLMQMDKYAEIIINMAQEVANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSC7</accession>
    <name>A0A4D6DSC7_9CAUD</name>
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            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
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            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <dbReference type="EMBL" id="QBZ69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="102" mass="12183" checksum="C28796F9A2361EDB" modified="2019-07-03" version="1">MTNPPRGVKIDLSNVREDFKMIPEGTYLKDSSGLNHYFIEGHIVGVRTGVRGYQTVVWDKELDKMYEQNFHEQSLMNDVKMSKKEIEEFNKKYYEWSWEQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSC9</accession>
    <name>A0A4D6DSC9_9CAUD</name>
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        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
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            <taxon>Duplodnaviria</taxon>
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            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="149" mass="17358" checksum="EDE48C4BEFA5A899" modified="2019-07-03" version="1">MNYEEFKKEIERISYLSIKNIEGNGVYIYSSLGENVLTVISILDTSYVDYNWRGRIKACDIHVLTEVVEKFAKTPFDERFPKNYRLLIGENYVSGITFTHSLLSADCKPEEPIEVTFNRDCPHLFNRKNKEQASKMLDAAKIKHTWEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSD0</accession>
    <name>A0A4D6DSD0_9CAUD</name>
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        <dbReference type="NCBI Taxonomy" id="2546635"/>
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            <taxon>Caudovirales</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="QBZ69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="38" mass="4345" checksum="9DACDC411A2844F7" modified="2019-07-03" version="1">MDMKDKLKLTALWILLGVSAVIALVEWLLPLLLLKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSD1</accession>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="68" mass="7580" checksum="7C585419FB86872B" modified="2019-07-03" version="1">MKDFLVVVMIGNKMLNFATSTEAMTMEFVESLKKELSEQLSEDLTPADITVLNIIPMDKKQSSLITGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSD6</accession>
    <name>A0A4D6DSD6_9CAUD</name>
    <protein>
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        <dbReference type="NCBI Taxonomy" id="2546635"/>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69267.1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="125" mass="14289" checksum="EE94DB81E9421E91" modified="2019-07-03" version="1">MSLGMFDKELLAALAALRWVVEDPEIKERHAEILNTAYMENAYEKGDSFPNEKFVEWDFINALTTLEIEAAARSLVIDDESYNGEEDLLYGDDTYPCGCCMCCGCSCDDYMWEDDGSFDDDDWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSD7</accession>
    <name>A0A4D6DSD7_9CAUD</name>
    <protein>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
    <organism evidence="3 4">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
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            <taxon>Siphoviridae</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041948">
        <property type="entry name" value="Rnl1/2_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Rnl2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T4_Rnl2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="T4_Rnl2_C" evidence="2">
        <location>
            <begin position="225"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QBZ69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="320" mass="36331" checksum="89D567D4240273C7" modified="2019-07-03" version="1">MDFLKYPSLVNHYAIGKSNRLVNRFDNILWYASEKIHGANASYALSATGEEYFAKRSGIINKDDKQFSMLPECVTSDIREGTKKLFEYYPEAESIHVFGEFFGKGVQVMDYDLVKEGKKAFRVFDVIAKLEDGSMSVCGINTWKYYFEQDSIVPYNTLGKTLKEFLETPPSEESALGGYSEGIVLKPLQGYRIKSTQDFLGVKYKTDKYLEVSHKPSKQRKEAPKLSNEQVEALNELGKYITKQRVLNVCSHGYFDLIDKNIGKIMLAVKQDAANEFNKEVGSNFTEKELVGLSNAYSGEIAKYIKEVIYESSLELLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSD8</accession>
    <name>A0A4D6DSD8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A4D6DSD9</accession>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <reference evidence="1 2" key="1">
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Schnabl B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
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                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="123" mass="14050" checksum="D7FF33989DDFB5EB" modified="2019-07-03" version="1">MTNIILIVLTLAVLKALEWVYKLLSKRLDKSIKFSRKKAKKRFIIARVTEEQAYTLRLLKAISKDDEAVCEATNKALLEYGYEEAGGHSYEKAREKFSSLPEVKNGIPLDEIESDEEADVQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSG2</accession>
    <name>A0A4D6DSG2_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="52" mass="5949" checksum="5E45B830B5F1217C" modified="2019-07-03" version="1">MTIEQVKDYGKAYGKELSTKEVKEFFEKHNDMPSLMDLAKFCGAMNEDGTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSJ0</accession>
    <name>A0A4D6DSJ0_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="76" mass="8938" checksum="E50F4EBECB60358D" modified="2019-07-03" version="1">MSEKLTKRIILAAVIVAYLITVGIIFGILWLVSLITGWEQLFFYLGVLFLIDLLWETTKYAFIRYNKDKHKTLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSJ8</accession>
    <name>A0A4D6DSJ8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="103" mass="12034" checksum="1FCE01FEF6936003" modified="2019-07-03" version="1">MRAIKMYSIKSYQQYLEKLGTVRKAAADFELNNSFSKKAHELIANQYAEDIEKLSQKVQEYHELIENIVSDEAEEDEKQLMEYLGTIRKQQKITEELESGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSK7</accession>
    <name>A0A4D6DSK7_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="134" mass="15804" checksum="CBFC8BCB38F6312E" modified="2019-07-03" version="1">MELIENTELFKSFEDVTLPPETEAIDITDLKLMLGYGNSTIRDNVLKVLKKRARQHICLFINKEVTDFPMELDYIADELTASRMSQLNSEGLKTESTDITRYDYKDDIYANWYGILNRWLEQQGEYRNKAFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSL8</accession>
    <name>A0A4D6DSL8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional autolysin / N-acetylmuramoyl-L-alanine amidase/ endo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="2">3.2.1.96</ecNumber>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="3.2.1.96" evidence="2"/>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="237" mass="26223" checksum="EB6AB85171BF0740" modified="2019-07-03" version="1">MVKLNDVLSYVNGLVGKGVDADGWYGTQCMDLTVDVMQRFFGWRPYGNAIALVDQPIPAGFQRIRTTSSTQIKAGDVMIWGLGYYAQYGHTGIATEDGRADGTFVSVDQNWINPSLEVGSPAAAIHHNMDGVWGVIRPPYEAAATPKPPAPKPDKPNLGQYKGDDDIMFIYYKKTKQGSTEQWFVIGGKRIYLPTMTYVNEANDLIKRYGGNTNVTTYNHDNFGLKMMEAALPQVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSM9</accession>
    <name>A0A4D6DSM9_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="47" mass="5454" checksum="2B6B5D3CAB2D2B3F" modified="2019-07-03" version="1">MQETVTISKREYERLLKVEAFLNALEAAGVDNWSGYGDAWEIFEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSN8</accession>
    <name>A0A4D6DSN8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="342" mass="39473" checksum="AD9B735DC66E8C8C" modified="2019-07-03" version="1">MAKGLTAINKAAGKTLVDTIAEDFKRQLNKWGETGYTYDSDVHHQLMRDYLKIVDRNPFEDFPENVPVFRSSGTGKCLREQTLFAIDKIEGSDRKDPPKMQAHQSRWVQIGTKVGDMIQEQVLMMEKNYRRFTGEDCHFRFERTEEGFPHFEEFSTTFKKYKSGRMEFITGGSMDGIMIWTDPSSGEEFRVGLEVKSKQTTPAATSAFSMRQPNSKHVWQVKNYAMLKDLGMYLIVYVNCAHKSWEMAEEDYDKNPDLQVFGVNISEQDKKDVRNRFFTAIEHAHAGTLPPLDLSGFTFSDYKYALAHSLTFKELEELEKKAVSKFDQKALEEIKKIRGDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSP8</accession>
    <name>A0A4D6DSP8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="74" mass="8184" checksum="0B501E5A3E9BAE31" modified="2019-07-03" version="1">MKLKDLLKVVDRMQDITLEIAGVTAPEGIYAQDIPVLREQALEMEVVDVHTAWYNAEDSIETTLGVVVKGGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSQ8</accession>
    <name>A0A4D6DSQ8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="210" mass="24303" checksum="C2F111914E6D8A9D" modified="2019-07-03" version="1">MKYTKKDLREGMKLRVIDDGYYSIWKTGSVHELIKRDGKLIIEGDDTLGRTLRDEYEILAYLNGEAHVKMEVVEEGILKSTGERLTRDNIKEGMKVVCVKSTYEPQRYFTVGKEYEVVMGNCGDLGIEDNDGEGFIWDCAIFNEDQFVFELLEEPSKKAALKALDNKIRELNNHQLELFQKRDRINEQAIQLGSKARRLEEAKALIEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSR7</accession>
    <name>A0A4D6DSR7_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="101" mass="11067" checksum="082BC78B5C0729E6" modified="2019-07-03" version="1">MDFNTLIEQVQEWSANKGLDKAAPEKQFLKVIEEVGEVAAAMARNDREELVDGLGDTFVTLIILCQQLGVAPHEALDTAYGVISKRTGKMVDGVFVKSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSS8</accession>
    <name>A0A4D6DSS8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="69" mass="8509" checksum="B2D6A36A00BF99B8" modified="2019-07-03" version="1">MFIVKIYRENSNRRLKLFHTSEEAENYVLRKLKGTDKKTIEVFEWDNIALELSYWNQSTREQESYILEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DST5</accession>
    <name>A0A4D6DST5_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="100" mass="11266" checksum="6E1872C1EC6F9CA4" modified="2019-07-03" version="1">MKLIDATVVLNHIEKAEEEFGNTFASGTDFEKGWDEGYLDGFGDIKGLVEDIIIEDEIPLANPSDMIPKSEFIRLLEAIKTHSADWEECIFIDGILEAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSU5</accession>
    <name>A0A4D6DSU5_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terminase large subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035413">
        <property type="entry name" value="Terminase_L_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035412">
        <property type="entry name" value="Terminase_L_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04466">
        <property type="entry name" value="Terminase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17288">
        <property type="entry name" value="Terminase_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_3" evidence="1">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Terminase_3C" evidence="2">
        <location>
            <begin position="262"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QBZ69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="423" mass="49378" checksum="9B62CA0A1E83FF26" modified="2019-07-03" version="1">MAEPIKLTITKRTFNEAYLPYMYNQPEGQHRTMVFYGGAGSGKSKFVVQNAILKGLSERRKFLVLRKVDNTIRDSIFQEFLVCLEEWNLLDFCEVKASYMTIKLPNKTEYIFKGLEDPERIKSIQGLTDIIMEEATEFTREDYDQLQTRLRHPTARHQQVFVMYNPASKDNWVYQYFHNPATKRPKGSKVICTTYKDNRFLPKAYLDHLQDLKNTNPVYYEIYALGKFASLGKRIYTNWRIDSAFNPKKLLDMGYEARFGLDFGFTNDPTVILSTLVSEADRVIYIFDEFVKTGMIAPEIFDVIKRKKLTNQLIYADSANLETIEQIKRLGARKIKPVKKGRNTVLHGIQYLQGYTIYVHPRCVHTIKELENYEWKPAKGSDDYENKPKQNGFDHCMDALRYAVNDLIPRNRIRTINKSVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSV4</accession>
    <name>A0A4D6DSV4_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BIG2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011855">
        <property type="entry name" value="Phgtail_TP901_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06199">
        <property type="entry name" value="Phage_tail_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02126">
        <property type="entry name" value="phgtail_TP901_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="229" mass="24619" checksum="401B02B41937B3F0" modified="2019-07-03" version="1">MEACKSSYIRGTAVLIEVQNDLGEWIKVAAQRGGTLNRTAATLDVSNKEGFGWDDAEAGNKSWSIDCDGLFVEDNAGFQALNAAWVNGDCVRVRVKFPSGLTYVGQAILTDFPYEFGYEDAVTYSLTFQGKGALEEQQVAPTILPKKVEFTNETKEVKVGETLQATIKFTPENVSDQSVTYTALTPALATIDESGLITGVKEGTASFNVRSNVNTAVSALIDIEVKPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSW4</accession>
    <name>A0A4D6DSW4_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="275" mass="30039" checksum="7AA77EA38663ED16" modified="2019-07-03" version="1">MAKGLEAIAQAAQAQSKGSGEQSKKTYLKKGQSIRARIPVDTLENLHVNQVVSVFEPQVLPTLSYHAEGRTDVRDLYHEATEIMLADHRAKVESGEIERGSQADKDSYKAARILTPKPLILFGVIPLADFTQGTKKTNTYPAGEPILLETNLGRDNANIDALTNFLSKETNAKKFPKKAFEITCEAANRYTFTPLDDEDLTAEELAVFIATEGATVPEEDFENAIFESTVERQIEDLKKIGFDVTRLPNLPTAAPAAIDKGADEAGTVDPSGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSX0</accession>
    <name>A0A4D6DSX0_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="103" mass="12094" checksum="0080933F3026614F" modified="2019-07-03" version="1">MNGFLEDGYYVVKMKYRGVYYEWEGVAEDEEDAFDKAKEVISEELNLIYYRGFEQHRVTRLKITHKKAPTYAALNFWKGVAAVSMVVSIAIYLFEMIRESIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSX4</accession>
    <name>A0A4D6DSX4_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Toprim domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QBZ69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="314" mass="36512" checksum="851EBC4D5F0BCBF5" modified="2019-07-03" version="1">MLDTIHLTKDIQIHIDIQEYLERFEWNRAKWTEDRLIAASPFRDDNHPSFFVNYNNDWAGTWGDSGTGDSGNFIQLVAELHETDYETALEMLKEEFWIKPYEAPAISVKLNVKKEKSVFDIPTHNTSEYLLGRGISEDTQKLYRTSEDESKVCLPYINGMGLATALKYRRTDNKDFFYEAGNNHLKNMLFGYHVIYEKLPNTLVICEAEIDAMTAYEMGFVGISLGAANLIERQVDLIKKVDVKNIIIGTDNDEKGNLAAKSIDDAFWKTHKLFRYDMPSGYDLNQYWQEFHKAPPLKKISEPKLLRRKLWYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSY1</accession>
    <name>A0A4D6DSY1_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="128" mass="14462" checksum="A08E88587574B27C" modified="2019-07-03" version="1">MMIASIDRGAYTPVNVSIGNKLVSLESYANIITFSKSETEELIQVLQQALKKLPEEPKYVVVFPQKSGELFWKYFYLADTGAIYNSNKPQEVLGDGAMTLGEIRAFSEHYEPFAVPVEEFKQNEIGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSY2</accession>
    <name>A0A4D6DSY2_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="210" mass="24481" checksum="BA3106A8455624BA" modified="2019-07-03" version="1">MANLLISEKSYYEKLVEAETANEFRMVLIRLINRVVMKVKVPLEVRELFCEEVLEMYYERFGDVALPDSLANILSTYYMQDDTRGDLEGTNKFARCSKMEYSFASDKKEKRIRTEDLYKESPINLEVLEGNGYSRNNIASSLDMERAALRTDLLKAMAKADLTEMEKKVLELNLIYDYTMREIEVLPDMPSRSTLSRHLTSARKKIMQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSZ0</accession>
    <name>A0A4D6DSZ0_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="268" mass="29907" checksum="E1FB0344410F757C" modified="2019-07-03" version="1">MAHEVTKIADLINPEVIGAFLHQKMLDNLVLAPFAEIDRTLQGRPGDTLTLPQWNFIGLAEDLAEGEELQSVKLTAEDRKATVKKVAKSVTLTDEAVLNAYVRPVDETVRQLAMAIAGKIDNDLFAAMRALTPSDVEITDSYEWVLDAQVAFGEEFDEETYLFISPKRRATILKSKDFVHIQQGVSVIKGHLGEIYGMNIVVSNKIGENEAFVLKRGALTLLMKRDYMVEEVREGMKRQTNITADQHYVAFVKDAKRAIFINKVAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DSZ1</accession>
    <name>A0A4D6DSZ1_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="61" mass="7108" checksum="38411B84D0A7C422" modified="2019-07-03" version="1">MANYYVLERLDDGSGKLHQVKCYRSLDKAIKYAKEMSTFKKTYQVAGQFDMNRLVNTGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="1331" mass="151028" checksum="78A57AF21D309846" modified="2019-07-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT02</accession>
    <name>A0A4D6DT02_9CAUD</name>
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    <reference evidence="1 2" key="1">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
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</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT05</accession>
    <name>A0A4D6DT05_9CAUD</name>
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT11</accession>
    <name>A0A4D6DT11_9CAUD</name>
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            <taxon>unclassified Saphexavirus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="QBZ69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="34" mass="4179" checksum="25A130FDE4186B29" modified="2019-07-03" version="1">MSKKTIEKLYKSYMSTCKEFREMVTFTQYVKGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT14</accession>
    <name>A0A4D6DT14_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69252.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="74" mass="8797" checksum="9D6734EFCC7A9D07" modified="2019-07-03" version="1">MSYYLSQMSNLKEKIRYEKTSVKLIRESIERIGKPTGEYSLGYTDALKMELLIHQKMLEDAQKELLDLEKERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT16</accession>
    <name>A0A4D6DT16_9CAUD</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT26</accession>
    <name>A0A4D6DT26_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>unclassified Saphexavirus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QBZ69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="57" mass="6677" checksum="157F1D10D2E83107" modified="2019-07-03" version="1">MTLFKSMLWAILIIIIALVFIFLVEVFVTYVSGIWVFVTFLAITFFYLTLMIYAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT36</accession>
    <name>A0A4D6DT36_9CAUD</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>unclassified Saphexavirus</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="49"/>
            <end position="69"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="198" mass="22848" checksum="394A0D48B033DF81" modified="2019-07-03" version="1">MPKKYYLKAISMYLLYALIAAVVIGGTFLLVNAFVWVGTFIYGRFGDTVGTILLLSTAGLIALCTALYYEARKEFREDALRVRIQDPEDGIDTQRFDIVYMLPEDVIRQASTIVGIIPEDIQHIESEELRKKVIHAIMKHSPVEYGFTLITEYDPDLDCMLREIWDLNYTFKTRRKLMEKLRECGVGLEGEFLKYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT40</accession>
    <name>A0A4D6DT40_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
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            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="88" mass="10243" checksum="B71F158DCA96B5FB" modified="2019-07-03" version="1">MSKHFYANTSPDMAVNYPKGWTSFFHNIVGYDEPLSKEVLTAYHLKEITDLNELPEHHKKVFETLSAIEYSTVEQALKTFKTNYVEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DT50</accession>
    <name>A0A4D6DT50_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="75" mass="9231" checksum="A262CF0246BBC9D7" modified="2019-07-03" version="1">MTQKFYVDSILYNPSIIVFEWDKKNKVVSFYNKIKEREETKKIKVDRDGDLYFYANGQTFYKRHLHVIEYKEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTE5</accession>
    <name>A0A4D6DTE5_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003647">
        <property type="entry name" value="Intron_nuc_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010902">
        <property type="entry name" value="NUMOD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07463">
        <property type="entry name" value="NUMOD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00497">
        <property type="entry name" value="IENR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUMOD4" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QBZ69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="252" mass="28359" checksum="5696BAA98EA2BC8E" modified="2019-07-03" version="1">MPIEEDLGGFLVKLIKEVKSVDVETGLETVYRSAHAAAKDLGKDSTSVRNACAKNKVYAGHVWSYTGKEFEKGSPLASKKPIKKYLEGDWKVVNGFPNYSITKTGKVVNNLTGKILKPFINDRGYAEIGLGDGNNKRLHRVMLSTYNPIEGWEELTVNHMDGNKLNNNLDNLEWLTHEDNLKHYYDNNKRILVFDDATGEVLEEVTRMEKASAKYGVPKGVIQELCDLYHEGIYAQENGYGFCRMEDFGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTF3</accession>
    <name>A0A4D6DTF3_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="125" mass="14048" checksum="11917AFDA0BB932E" modified="2019-07-03" version="1">MPFEESNLEVIVNDLIKDVNTHANQIASIQSDLNRMTTDISSVRDLLIKNTERSDVLIGHIKGQSDEMLKLLTEERRRQTESYLADEASDRKNKEFSQKQMWAVATALVTGVGSALVTIVKLIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTG3</accession>
    <name>A0A4D6DTG3_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="126" mass="14089" checksum="2E71E86ACA9647A0" modified="2019-07-03" version="1">MAGFLEITKRIDFAGLEREFVNEVKGVVEKNSAQMATAVRFNIVRRGNIDTGTYYDGIKSKTEVEGKGKSVTGIVESDVSGNPYGHRGYAVYLEEGTYRHQAFPNFTDALEEYSDILVEQLSRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTH2</accession>
    <name>A0A4D6DTH2_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="142" mass="16532" checksum="63B1E4EBE6FABDF3" modified="2019-07-03" version="1">MAWIRTKENKLYKDAEGNKVDTKDWQNAPVSMWNTTTFMEYVAHLNQQKYGRVPINASLQTLRAIMKKDIERFGTEALKIFLEMAVADYNGNARYPTLSYSQARLLYMERFMSVAIEKAQQKAVDEATPQTEYTLEEVETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTI2</accession>
    <name>A0A4D6DTI2_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="83" mass="9756" checksum="B18FFB2A58D984B8" modified="2019-07-03" version="1">MDKPYVALTNIHTGKIVYCTEEWLFHRSVKEAMPCKSIEYVDMSLCGMESFYRVVFKANQYTYVEDLPVSNFTAVRMLDKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTJ2</accession>
    <name>A0A4D6DTJ2_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11"/>
    <dbReference type="EMBL" id="MK721189">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
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        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QBZ69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="189" mass="20970" checksum="9349FFD5BB1C28C6" modified="2019-07-03" version="1">MRFISFDVSSVSTGVAVIDREPSGYLTLVHTDIISTNPKHNVGRRLKDFAEAVQILLETFRPDYVVKEQTIARMATQHILLKFAGVLEMIASNEGFPKIYEYSPTTVKKVVGGHGRATKEAVLMGTTEYINWNEPIDLVIDDISDAVAICLTHIGKEFVLVPLGEVEKAKEEAMIVEAEASKYLEEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTK2</accession>
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    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="70" mass="8063" checksum="CBB5216B7F81628C" modified="2019-07-03" version="1">MLIRVNEAEGSTSFIEYIELSQAYGGKINIEFFVEDVEEDNAFPTDEFYMDDETVDKLIKALQSFKEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTL1</accession>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69276.1"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <person name="Fouts D.E."/>
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                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="79" mass="9052" checksum="FC8AB2C274002385" modified="2019-07-03" version="1">MTPELAEMNLTKHDSPFSFINESGVFIEPIKNPFSCEGTYLQACKDVAGELETNKEVGNDIDNYLKMQNWLNKLAYEYI</sequence>
</entry>
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    <accession>A0A4D6DTU4</accession>
    <name>A0A4D6DTU4_9CAUD</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="71" mass="8097" checksum="1E45C4A9C19B8CDE" modified="2019-07-03" version="1">MDSRAPRPPSEKLPPALPKDPRPPWPRLRPAPSFTLREALRVLCDALTSRRPTRSHKRLDLDSVSLLLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTV6</accession>
    <name>A0A4D6DTV6_9CAUD</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="123" mass="13349" checksum="C57CBA805CC0091F" modified="2019-07-03" version="1">MKLIDGEALLTTMKNKLEYPEDDYDEGYQDAVETCMDEIKAALSVAKEEDAPEPIKLAVDGNIVAESFTGSSVTPINTLPHNYTKDVLEALLEASEDFYDASEIQALLKGAIQAIPKGKGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTW6</accession>
    <name>A0A4D6DTW6_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
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        <lineage>
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            <taxon>Caudoviricetes</taxon>
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            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006428">
        <property type="entry name" value="Portal_SPP1-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01538">
        <property type="entry name" value="portal_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="511" mass="57953" checksum="9F9C1951D05E5B33" modified="2019-07-03" version="1">MAIPNGQINAGDIITTNIRRKHFIRRNYDIRELVTLAEMHSRSSSAYGVLYDYYKGNHIAIQSRTFDDTNKPNSKIVHNFPKLLVDTSTAYLAGEPITESGDEKTIKAMQPVMKENYVTDVNSEEIKLSGIFGHCFEIHWIDRNNKHRFKAVSPMNCLIAYSADLDEEPLAAIYYNTVISDITGHVIRTYEIYTEDKILKFSTDDERDVYKEIPEVLDIRGYEEHPNLLKKFPVLEIIANEERLGDFEAQLSLIDAYNLAVSDSVNDIAYWNDAYLWLQGFDLSADSDSISNMKNDRVIVTDDTGNVKFITKDVNDKHIENIKNRAKLDIFSLSQTPDLVSKDFTAASGQALKAATQPLENKSAVKESKFRKVLAKRYELICSYLELMSKEKDLKPNEVTPVFVRNLPQSYAELADMAVKLRDMLPDETIINQFPWITDARLEVEKADEQRQKRADIALQNFKQTSAVQGASTAAANKLDKNPANTSTITTTDPVAAKEQEKAIQKKPKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTX6</accession>
    <name>A0A4D6DTX6_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="174" mass="20208" checksum="D8863950332EC161" modified="2019-07-03" version="1">MEIDCTEGGLGINSLALFLHNKYKGDYNMIIRFQGKDLNLRLTYKSIHFLELAFDQDYTSFIAEQTPFNQSLYIFWAMLQNESDYEGVSVLDVAELLQDSLDSYEFTLEEYFEKVNSSYASSILVKQLFKNNTGSLPRGGGRRGRASEARRKILYGIVYRLRNTFQRLLDKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTY8</accession>
    <name>A0A4D6DTY8_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="144" mass="16493" checksum="99E13880A65D39B7" modified="2019-07-03" version="1">MKKDTPKVNPIKFTEEDYFRLLQTVVMTNTFIGSLSAGFQGKERLEKITKIAENMFVLNRLMESAESNGEDWGDEMLLDSLYSDSEVLVTKYKHLLSEAQLESINNSIKNFAESAEKARKEAYEEKVAQAEVIDFKEAKKKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DTZ8</accession>
    <name>A0A4D6DTZ8_9CAUD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IstB_IS21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="258" mass="29781" checksum="C9B30EE1BBDD32D6" modified="2019-07-03" version="1">MRKQTLLEKLKQVTGKTEKELNPTLSHIHIQLCGGSGTGGKFGAAKVPYDYSDNFLFNSPARDTQKDVYKQLEVYVESFKRDFQKDGNINQDERPIKNIYLWSENKGNGKTSTAAALLNEYMFMSWQASVILKTNMKQPPAYFLDVNSFQTLYNKFTRNGIAKDIAEKTSREYYEMMELAETAPLVVFDEIGNRSATEAFRADLHDIINKRMVNKLPSIFTSNHPIEYLEQVFDERLADRVRERTMVYNFKGESHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DU04</accession>
    <name>A0A4D6DU04_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="187" mass="21421" checksum="1F112175E6356CB6" modified="2019-07-03" version="1">MPRTNNKISRKKALEVYLEGSNPLAAISELIEEHTWTVGFDVESATFYKERTSNPYDTCKNPRCKLCKQIREHAERIPAYSLGKTLAKPFDELSLGHFGKLAANDVAKSDMPKLLKVSMKDINNHIEMLVEKIGLDNSINLLKDYELSEQVIQQLLGIGVYDMRQFKKRMYEGKKQRIAEAKKGEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DU13</accession>
    <name>A0A4D6DU13_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase I</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039693">
        <property type="term" value="P:viral DNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-1194">Viral DNA replication</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="3">
        <location>
            <begin position="104"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="4">
        <location>
            <begin position="511"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QBZ69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="843" mass="95521" checksum="00EF15568F7D91F7" modified="2019-07-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DU24</accession>
    <name>A0A4D6DU24_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="71" mass="8245" checksum="4A6813D3F94E3BB4" modified="2019-07-03" version="1">MEFNEAELYYLQALLKRDFEELGEMLDANLAIGASDSILECFTEYQALNLKLKSMFSLQIEKIWEDFANAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DU34</accession>
    <name>A0A4D6DU34_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QBZ69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="128" mass="14527" checksum="C19D142E08D3EFE0" modified="2019-07-03" version="1">MALTMFEKESLQKENARLKRELATLKASQKLGGGLDEKELQKALNSCQRIFKTLNRGKRSLVLSKSAMVASVEYSGSGRSKTYKDCSKTAIREAEKSAWEIMSLENDFRNIHHFLKHGTMKAEEKDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DU44</accession>
    <name>A0A4D6DU44_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="100" mass="11227" checksum="2003099AE2902468" modified="2019-07-03" version="1">MKKQLKNIIAGLTILAIALAITTGIATFKAVENANDKAILTERVEALEKLSEKQEYDIAVKSNVIGAYLINHEEEAQKEYTEAYKAHKPTLLKNYREAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-03" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A4D6DS96</accession>
    <name>A0A4D6DS96_9CAUD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Enterococcus phage vB_EfaS_Ef2.2</name>
        <dbReference type="NCBI Taxonomy" id="2546635"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Uroviricota</taxon>
            <taxon>Caudoviricetes</taxon>
            <taxon>Caudovirales</taxon>
            <taxon>Siphoviridae</taxon>
            <taxon>Saphexavirus</taxon>
            <taxon>unclassified Saphexavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-03" db="EMBL/GenBank/DDBJ databases">
            <title>Bacteriophages that Target Cytolytic Enterococcus faecalis Reduce Features of Ethanol-induced Liver Disease.</title>
            <authorList>
                <person name="Fouts D.E."/>
                <person name="Duan Y."/>
                <person name="White R.C."/>
                <person name="Nguyen K."/>
                <person name="Singh I."/>
                <person name="Schnabl B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="MK721189">
        <property type="protein sequence ID" value="QBZ69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000297121">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QBZ69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000297121"/>
        </source>
    </evidence>
    <sequence length="74" mass="8086" checksum="A07AC15E9021F9E6" modified="2019-07-03" version="1">MYSNHSLSFQTVLRWLFIASSILSESLPALNEAFSDCTPIFLNEASGMLFLPVISLFLITPAVISEASNDFGSL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>