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<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A140H645</accession>
    <name>A0A140H645_9VIRU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Replication-associated polyprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Fusarium graminearum mycotymovirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1809243"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Kitrinoviricota</taxon>
            <taxon>Alsuviricetes</taxon>
            <taxon>Tymovirales</taxon>
            <taxon>unclassified Tymovirales</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Virology" volume="489" first="86" last="94">
            <title>Molecular characterization of a novel mycovirus of the family Tymoviridae isolated from the plant pathogenic fungus Fusarium graminearum.</title>
            <authorList>
                <person name="Li P."/>
                <person name="Lin Y."/>
                <person name="Zhang H."/>
                <person name="Wang S."/>
                <person name="Qiu D."/>
                <person name="Guo L."/>
            </authorList>
            <dbReference type="PubMed" id="26744993"/>
            <dbReference type="DOI" id="10.1016/j.virol.2015.12.004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SX64</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT360947">
        <property type="protein sequence ID" value="AMN92730.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000290315">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008174">
        <property type="term" value="F:mRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039694">
        <property type="term" value="P:viral RNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027351">
        <property type="entry name" value="(+)RNA_virus_helicase_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002588">
        <property type="entry name" value="Alphavirus-like_MT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008043">
        <property type="entry name" value="Peptidase_C21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007094">
        <property type="entry name" value="RNA-dir_pol_PSvirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001788">
        <property type="entry name" value="Tymovirus_RNA-dep_RNA_pol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043181">
        <property type="entry name" value="TYMV_endopept_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05381">
        <property type="entry name" value="Peptidase_C21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00978">
        <property type="entry name" value="RdRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01443">
        <property type="entry name" value="Viral_helicase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01660">
        <property type="entry name" value="Vmethyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51743">
        <property type="entry name" value="ALPHAVIRUS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50507">
        <property type="entry name" value="RDRP_SSRNA_POS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0693">Viral RNA replication</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Alphavirus-like MT" evidence="9">
        <location>
            <begin position="346"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="RdRp catalytic" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1745"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="892"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1751"/>
            <end position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AMN92730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000290315"/>
        </source>
    </evidence>
    <sequence length="2242" mass="249548" checksum="80E1F21CF44034CE" modified="2016-05-11" version="1" precursor="true">MSQWPGLITLSPPPASCSWSRPSPTKSDNEKPASAVSCTHSSSCPSGPLSSSSESAGSGEPSLDRRALSSIEHSQFVNAFNPVAPLTRANPPTTSSPSQSRPSPQTSRPKLAGPRGRKKPLSREDKAALLAEAYARTTAISPISNGLSFGARKDRTRNDSLDRALDKIASLNAATTKAALAKVARKTLRTNRVRTLDPSIPGLCYLNALPKTLWAGVARVFEYEMTRSHLLLLLQTMDAARPRPNYTVNLRIDGDHLERAPPGKRQTDLLVRWLSTPGKESTLVGAPRAHFSNALDVLGGTIHKDAVLDNYTQPTVNAINDSMRWCPNAIPEPNFSLLAGKGLPVDVNATGSHPHPAAKAVEEDLLRTLSFSLRDDTTVYFMKQEKFNRLQANQPRFSHLVNPVLSARDTVRFTPGYQRLSTPPSTPTVFLHDVGHYLSCGEVARLFDEFPAMQRLMFSAILPEEVMLGEPSWHPSLYRLEHLDADSYSYILSEDGESYEQPYSTLEWLTTKSITAPAGRLSVEVIHRKFSHKLFVVTRAEALVPRDWWVCDSPDDVVLPHVDGRILRHSSQRVPRTIFQSVLLHSMSLSTQRLSSTIAKVRTFSSNPQYSHIDADTWVALAQTCYAMSLEPASLEREAPFNSYAAFMLRRLRRFMHSHDWLLPFLVGGGFAISWGSLLLPVLGIRIPDWHVRSGLKIPGWSYGAVAAAMSQVALCFFEGKYSSAVYALRAAAVAIPHLAYLLPDFTLRSGFTVPSFVGGLGLSFLTAVTISFFDGVSPHYEVHDFVARLPHRDQRRWRLRDVRIHREADVLWWEPLRSVPLEPENDDIPPAYSSDPLPEDAEYRPFVNVPFFNLWRQHVHRETVPLTFPRDTWSINSTTGTGERLPYRSVHVSEASSSSGSTSSGDPPTDADDVSMPGSATSSNSLDFATLPSIDTCSLLRCFRDGDSAGATTESSSFPQPQPPHDAPSFTFTDNSCVAPSPVVSESAVPLGPSGADFPPSRPHVNLGATPTAPPPREGVPLRLQFDLGAAAVLEPDDLFSCDPPEDSTVLPYPLNDCLLRAIENTTGVDRQEVWRVCCRVLPRAELEGPEVDEGGLTTLCALAFAYEYRCQFHILGDLQGHHPEFIGVSHPDFSRLNRAVYNVYFTPGHWSSGPEAPLRGSAPPPHTANVQPAHRRPTRFEQALVDLRDHRGSPLFQNWYSYTTSPARAKPYVRDLKAGTTGTMRSNEGKDRVPKGFTASLDSMVDNHRPRQVLCAAILGAPGCAKSTSVRALLRQAWTQRGNTWKVSVPRVKLRKDWVDRLALGKLSFKVGTFETSMHTSAKCLIVDEVSQFPPGYIDACLIKDSTITSVLIIGDVTQGGFHESDCDSTLNSSGCEALYFRNFCSLYRNYSFSIPRAVSNAIGLPTASSTRGSIQLVTRADPRWPIVCASNSEVAMYSSQGFDAYSFGTVQGQRFEQVPIQIVISNATALLVSRGHFVSALCRSNVGVRFLFAGTHQAVMALQSEPFYASLFSARPRMSYTDLFREELRGLTLSQTPGFWDPLNASDNPPPIFTARQYPNFTLFRGASSRSSRIDHRPALPEVLSADAPGCCWLQLLDEEELPDLKPPHTCMTAQEVLDFVAREGVLLNEVDLFVPSFSHNHPYSNAPGGAMLHLRVNTRGIQAQELLRRLVRSGNGHIPMGADATELPIDRASLPLQALLSAPPDFLPTSTEHDDNMERGPPTGNFVEDEEFLLLSFGELPDRSPRESYTQFDQSQQFRDDPWYQSNPSASNLEQVFPRHRGDDLVTFARTVEKRLRFAPRHTNLSRFHDRLFVGPILYNGWLRATGITHESIPPFDADLYAQCILENEFTKLTNKTQATLLNNADRADPDWRHTFVRIFMKSQLKVKLETILSPFKAGQTLASFQDSVILVTGPMTRYLVHQSERLFRPQYYHHPGHSPLALSTWCQKHWKSRPLNSTNDYTAFDQSQTGEALSFELMMLRAFGIPDGVISYYTELKLELTCQFGELAVMRFTGEGPTLWFNGCFNTALVGVQYDFPSDTAIAVAGDDLAMNGVFPERPGWQFLRRYLTIEAKPETVKTASFCSWLLTPHGAIKEPRVVFAKLMIARDRGEEAKSLPNLLNEVAVGYHLGDHVYEHLDDLSLATHFWLIRYFVRKAPHRFALLLTTRSIEEVLAHIWHLVEQRTRTALRELDARFGQLWMLHSRPARLAASVLSRVRGSQLSGLRVFDHTFTRLYTH</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>