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<entry dataset="TrEMBL" created="2015-05-27" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0D3R1M7</accession>
    <name>A0A0D3R1M7_9RHAB</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Matrix protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Radi vesiculovirus</name>
        <dbReference type="NCBI Taxonomy" id="1972566"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="E1004664" last="E1004664">
            <title>Evolution of genome size and complexity in the rhabdoviridae.</title>
            <authorList>
                <person name="Walker P.J."/>
                <person name="Firth C."/>
                <person name="Widen S.G."/>
                <person name="Blasdell K.R."/>
                <person name="Guzman H."/>
                <person name="Wood T.G."/>
                <person name="Paradkar P.N."/>
                <person name="Holmes E.C."/>
                <person name="Tesh R.B."/>
                <person name="Vasilakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25679389"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ISS Phl-166</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host endomembrane system</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Virion membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vesiculoviruses matrix protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KM205024">
        <property type="protein sequence ID" value="AJR28594.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033645">
        <property type="term" value="C:host cell endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039660">
        <property type="term" value="F:structural constituent of virion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009397">
        <property type="entry name" value="Vesiculo_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036711">
        <property type="entry name" value="VSV_matrix_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06326">
        <property type="entry name" value="Vesiculo_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75404">
        <property type="entry name" value="SSF75404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1043">Host membrane</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0468">Viral matrix protein</keyword>
    <keyword evidence="8" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AJR28594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000232933"/>
        </source>
    </evidence>
    <sequence length="234" mass="27100" checksum="D738A38FB5BCE155" modified="2015-05-27" version="1">MKGFKAMFSKKKSKKGKEIKAKGKGKDKNKQYDEDERPPAYFNVAPEWGSASAPMFGYDEYIESQSSIQSLKIQFRYSLEVTVDYPFANFFEALQSMRNWKIDYTGYQNKKSIYNIIMMYATKRLRAGPRGLQGRKSTEYSAEGSGRYTLHHDLGDLSGMRFAEERFVRTWQDQLRRGTINFYVWLGETDDNSNLPPLICPGDFKDASEFNMSCEIMGIRVEVQPDNQWVVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0D3R1T8</accession>
    <name>A0A0D3R1T8_9RHAB</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein M1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Radi vesiculovirus</name>
        <dbReference type="NCBI Taxonomy" id="1972566"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="E1004664" last="E1004664">
            <title>Evolution of genome size and complexity in the rhabdoviridae.</title>
            <authorList>
                <person name="Walker P.J."/>
                <person name="Firth C."/>
                <person name="Widen S.G."/>
                <person name="Blasdell K.R."/>
                <person name="Guzman H."/>
                <person name="Wood T.G."/>
                <person name="Paradkar P.N."/>
                <person name="Holmes E.C."/>
                <person name="Tesh R.B."/>
                <person name="Vasilakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25679389"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ISS Phl-166</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. May act as a chaperone for newly synthesized free N protein, so-called N(0). Plays a role in virion assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vesiculovirus protein P family.</text>
    </comment>
    <dbReference type="EMBL" id="KM205024">
        <property type="protein sequence ID" value="AJR28593.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043036">
        <property type="entry name" value="Phosphoprotein_C_viral"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AJR28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000232933"/>
        </source>
    </evidence>
    <sequence length="259" mass="29242" checksum="CC0628AB9A80F143" modified="2015-05-27" version="1">MDLQRSAFEALRNYPNLENALADADESESLRDPPSPNSSQAHESEGEKFYLTDQLDLLESSDEEDEDLSTDIGSSGQHQDTYSNIDDRSASNQDEDSEEEREAYGVHFPSEKPTIDLSDLPATLQRRIFVDISNAFKKMMEAPSCQHFPVMVRGRIELIPSSDMAIHQTPSSATTPESEDLPPSPVKRDRLLDRFKIHHRSTQDPLETSFVEIFGSEDSARAAWGDGSLSYKELLILGLRRKGVFNRMRIAYDLTPIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0D3R1W3</accession>
    <name>A0A0D3R1W3_9RHAB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Radi vesiculovirus</name>
        <dbReference type="NCBI Taxonomy" id="1972566"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="E1004664" last="E1004664">
            <title>Evolution of genome size and complexity in the rhabdoviridae.</title>
            <authorList>
                <person name="Walker P.J."/>
                <person name="Firth C."/>
                <person name="Widen S.G."/>
                <person name="Blasdell K.R."/>
                <person name="Guzman H."/>
                <person name="Wood T.G."/>
                <person name="Paradkar P.N."/>
                <person name="Holmes E.C."/>
                <person name="Tesh R.B."/>
                <person name="Vasilakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25679389"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ISS Phl-166</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vesiculovirus glycoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="KM205024">
        <property type="protein sequence ID" value="AJR28591.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001903">
        <property type="entry name" value="Rhabd_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00974">
        <property type="entry name" value="Rhabdo_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <keyword evidence="7" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AJR28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000232933"/>
        </source>
    </evidence>
    <sequence length="556" mass="61934" checksum="0AAAE9A04D410E78" modified="2015-05-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0D3R2A8</accession>
    <name>A0A0D3R2A8_9RHAB</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nucleocapsid protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Radi vesiculovirus</name>
        <dbReference type="NCBI Taxonomy" id="1972566"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="E1004664" last="E1004664">
            <title>Evolution of genome size and complexity in the rhabdoviridae.</title>
            <authorList>
                <person name="Walker P.J."/>
                <person name="Firth C."/>
                <person name="Widen S.G."/>
                <person name="Blasdell K.R."/>
                <person name="Guzman H."/>
                <person name="Wood T.G."/>
                <person name="Paradkar P.N."/>
                <person name="Holmes E.C."/>
                <person name="Tesh R.B."/>
                <person name="Vasilakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25679389"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ISS Phl-166</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vesiculovirus nucleocapsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KM205024">
        <property type="protein sequence ID" value="AJR28592.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019029">
        <property type="term" value="C:helical viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019013">
        <property type="term" value="C:viral nucleocapsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000448">
        <property type="entry name" value="Rhabdo_ncapsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023331">
        <property type="entry name" value="Rhabdovirus_ncapsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023330">
        <property type="entry name" value="Rhabdovirus_ncapsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035961">
        <property type="entry name" value="Rhabdovirus_nucleoprotein-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00945">
        <property type="entry name" value="Rhabdo_ncap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140809">
        <property type="entry name" value="SSF140809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="6" id="KW-1139">Helical capsid protein</keyword>
    <keyword evidence="11" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="8" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Rhabdo_ncap" evidence="14">
        <location>
            <begin position="12"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AJR28592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000232933"/>
        </source>
    </evidence>
    <sequence length="428" mass="48056" checksum="B3FFD12AE69EF122" modified="2015-05-27" version="1">MLSKIKHIASGTEVEVRLPASEDPVEYPGDYFSKNRQKPKLYICDGANLDDMRQSVEQGLISRNVDICHVNAYLYHVLKDIEAVADQDWSSFGISIAKAGDRVKLFDMLDVETLNQKPSAGQACPTATKEDDRWLPMYLLGLYRVGRATVVSYQSELLEALSNQCKLRSKEFKELVQTQSDFFEAWGNDLNFTKIVAAVDMFFHKFKKHPDAALRFGTIVSRFRDCASLSTFHHLVKVTGLSLEVVGTWILNDQVAKEIIQMMKPGQEIDQADSYMPYLIDFGLSTKSPYSSVKNPCFHFWGQTTALLLRSGRAKNARAPDDIPYQSLTHASLLFAYAVGRTSDIAQRFSTGETYKSETAGTSGQPKGNPLVDAVEPSSSNVVHWLAWWDDVGRVPTKEMEAFAKRAVHGLTDLRVKSIGRHIKTHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0D3R2F8</accession>
    <name>A0A0D3R2F8_9RHAB</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-directed RNA polymerase L</fullName>
            <ecNumber evidence="21">2.1.1.375</ecNumber>
            <ecNumber evidence="6">2.7.7.48</ecNumber>
            <ecNumber evidence="7">2.7.7.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Large structural protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Replicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Transcriptase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Radi vesiculovirus</name>
        <dbReference type="NCBI Taxonomy" id="1972566"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="PLoS Pathog." volume="11" first="E1004664" last="E1004664">
            <title>Evolution of genome size and complexity in the rhabdoviridae.</title>
            <authorList>
                <person name="Walker P.J."/>
                <person name="Firth C."/>
                <person name="Widen S.G."/>
                <person name="Blasdell K.R."/>
                <person name="Guzman H."/>
                <person name="Wood T.G."/>
                <person name="Paradkar P.N."/>
                <person name="Holmes E.C."/>
                <person name="Tesh R.B."/>
                <person name="Vasilakis N."/>
            </authorList>
            <dbReference type="PubMed" id="25679389"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ISS Phl-166</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65440"/>
            <dbReference type="Rhea" id="RHEA-COMP:16798"/>
            <dbReference type="Rhea" id="RHEA-COMP:16801"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156482"/>
            <dbReference type="ChEBI" id="CHEBI:156483"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65376"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16798"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156483"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
            <dbReference type="EC" id="2.1.1.375"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65380"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156482"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:65436"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
            <dbReference type="ChEBI" id="CHEBI:156503"/>
            <dbReference type="EC" id="2.7.7.88"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the rhabdoviridae protein L family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.375" evidence="21"/>
    <dbReference type="EC" id="2.7.7.48" evidence="6"/>
    <dbReference type="EC" id="2.7.7.88" evidence="7"/>
    <dbReference type="EMBL" id="KM205024">
        <property type="protein sequence ID" value="AJR28590.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000232933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039530">
        <property type="entry name" value="L_methyltransferase_rhabdo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039736">
        <property type="entry name" value="L_poly_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026890">
        <property type="entry name" value="Mononeg_mRNAcap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014023">
        <property type="entry name" value="Mononeg_RNA_pol_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025786">
        <property type="entry name" value="Mononega_L_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017234">
        <property type="entry name" value="RNA-dir_pol_rhabdovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14314">
        <property type="entry name" value="Methyltrans_Mon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14318">
        <property type="entry name" value="Mononeg_mRNAcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00946">
        <property type="entry name" value="Mononeg_RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037546">
        <property type="entry name" value="RNA_pol_RhabdoV_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04198">
        <property type="entry name" value="paramyx_RNAcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50526">
        <property type="entry name" value="RDRP_SSRNA_NEG_NONSEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51590">
        <property type="entry name" value="SAM_MT_MNV_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0946">Virion</keyword>
    <feature type="domain" description="RdRp catalytic" evidence="25">
        <location>
            <begin position="591"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Mononegavirus-type SAM-dependent 2'-O-MTase" evidence="26">
        <location>
            <begin position="1632"/>
            <end position="1829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="AJR28590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000232933"/>
        </source>
    </evidence>
    <sequence length="2100" mass="239474" checksum="2DB364ECE46C53C8" modified="2015-05-27" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>