<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW1</accession>
    <name>Q9DHW1_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Movement protein BC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Movement protein BL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BC1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to dimeric supercoiled plasmid DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Host cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Host endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the begomovirus movement protein BC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012082">
        <property type="protein sequence ID" value="CAC18828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620300.1">
        <property type="nucleotide sequence ID" value="NC_003709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991154"/>
    <dbReference type="KEGG" id="vg:991154"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044167">
        <property type="term" value="C:host cell endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046740">
        <property type="term" value="P:transport of virus in host, cell to cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000211">
        <property type="entry name" value="Gemini_BL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00845">
        <property type="entry name" value="Gemini_BL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1038">Host endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1044">Host microsome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC18828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="306" mass="34827" checksum="D27E26835DFF6221" modified="2001-03-01" version="1">MEGAYTVTNKYIHTKRTEYTLTTDATPITLQFPSSIEQTRVRLLGRCMKIDHIIIEYRNQVPFNATGSVIIEIRDNRISDEEAAQAAFTFPIACNVDLHYFSSSFFSVAEQCPWEIVYRVEDSNVLNGVRFASFKAKLRLSSARHSTDIMFKAPTIKILTKGYKEDCIDFWSVERGETRRRLLNPTPSAQSNRALSKRPITILPGETWATKSHVGLPSESDSQSRDTYRSQSMRLDHTRSFTGTSYESDDTPYAGLHRLQTATLDPGDSVSQTRSENFSRQDLESILENTINKCLIKNKSDKNQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW2</accession>
    <name>Q9DHW2_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear shuttle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein BR1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein BV1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BV1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to single-stranded and double-stranded viral DNA. Interacts with the host nuclear shuttle interacting (NSI) protein. This interaction may allow NSP to recruit NSI monomers to the viral genome and thus regulate nuclear export of viral genome by NSP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the begomovirus nuclear shuttle protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012082">
        <property type="protein sequence ID" value="CAC18827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620299.1">
        <property type="nucleotide sequence ID" value="NC_003709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991155"/>
    <dbReference type="KEGG" id="vg:991155"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051027">
        <property type="term" value="P:DNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001530">
        <property type="entry name" value="Gemini_BR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000263">
        <property type="entry name" value="GV_A/BR1_coat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00844">
        <property type="entry name" value="Gemini_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00225">
        <property type="entry name" value="GEMCOATBR1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="5" id="KW-1043">Host membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC18827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="251" mass="28899" checksum="390B299EC79D5D02" modified="2001-03-01" version="1">MRRYDGTPQSTRGRKRKQFSRPFKSVLFRRRQASRRLFAEKPREKLSRRCLEDVHSGPSYALMNQCDVTSYVTYPILGLEGNGGRSRDFIKLMNVRVSGTINVTPLPAEPMSDRSPMNGIFVLLLIVDRKPFVPEGVNVLPSFKELFGEYECVYGIPRVKENQRHRYRILGMWKQYVSGDDSAVQKDFTLRRNLSGPRYNVWAAFKDIDQMSTGGNYKNVSKNAILACNVWVSTVRSKCEVYSQFVLDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW3</accession>
    <name>Q9DHW3_9GEMI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">c4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620298.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991150"/>
    <dbReference type="KEGG" id="vg:991150"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC18826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="47" mass="4924" checksum="2D213DA5A29A0AB0" modified="2001-03-01" version="1">MGNLISMCSCSSPERSQSQTIASSITYTQAVAPVSTPTYKALSPVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW4</accession>
    <name>Q9DHW4_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 24">Replication-associated protein</fullName>
            <shortName evidence="24">Rep</shortName>
            <ecNumber evidence="24">3.1.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">rep</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21 24">Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="23">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="23">Divalent metal cations, possibly Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 24">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="24">There are 3 rolling circle replication (RCR) motifs. RCR-2 is probably involved in metal coordination. RCR-3 is required for phosphodiester bond cleavage for initiation of RCR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the geminiviridae Rep protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.-" evidence="24"/>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620297.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9DHW4"/>
    <dbReference type="GeneID" id="991152"/>
    <dbReference type="KEGG" id="vg:991152"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016888">
        <property type="term" value="F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001301">
        <property type="entry name" value="Gemini_AL1_CLV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001191">
        <property type="entry name" value="Gemini_AL1_REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022690">
        <property type="entry name" value="Gemini_AL1_REP_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022692">
        <property type="entry name" value="Gemini_AL1_REP_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00799">
        <property type="entry name" value="Gemini_AL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08283">
        <property type="entry name" value="Gemini_AL1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00227">
        <property type="entry name" value="GEMCOATAL1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00228">
        <property type="entry name" value="GEMCOATCLVL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18 24" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="19 24" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 24" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 24" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="7" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="15 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20 24" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 24" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gemini_AL1" evidence="25">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Gemini_AL1_M" evidence="26">
        <location>
            <begin position="125"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="For DNA cleavage activity" evidence="22">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR601191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF08283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAC18825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="361" mass="41146" checksum="4AD28801F41C7753" modified="2001-03-01" version="1">MRPPRFRIQAKNIFLTYPRCSLSKEELLSFLVGLSLPSNLKYVKVCRELHQNGEPHLHVLLQFAGKITITDNRLFDHVHPSRSACFHPNIQSAKSSTDVKSYLDKDGDIVEWGKFQIDGRSARGGQQTANDAYATALNMSNKGEAMSVIKELAPKDYVLHYHNIRSNLDRIFEEPVAPFVCPFPMSSFTLLPPELVDWASTNVCSSAARPWRPKSIVVEGESRTGKTMWARSLGPHNYLCGHLDLSPKIYSNDAWYNVIDDVDPHYLKHFKEFMGAQRDWQSNTKYGKPIQIKGGIPTIFLCNPGPSSSYKEFLEEEKNYALKEWAEKNAEFVFLTEPLFSAEHQDQTQTRQKEDDSATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW5</accession>
    <name>Q9DHW5_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Transcriptional activator protein</fullName>
            <shortName evidence="14">TrAP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">c2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Strong activator of the late viral genes promoters. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense. Determines pathogenicity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. Homodimer. Homooligomer. Self-interaction correlates with nuclear localization and efficient activation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 14">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The zinc finger and the transactivation region are involved in PTGS suppression.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the geminiviridae transcriptional activator protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620296.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991148"/>
    <dbReference type="KEGG" id="vg:991148"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000942">
        <property type="entry name" value="Gemini_AL2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01440">
        <property type="entry name" value="Gemini_AL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00230">
        <property type="entry name" value="GEMCOATAL2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0010">Activator</keyword>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="14" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0941">Suppressor of RNA silencing</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAC18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="135" mass="15378" checksum="2D98AEF97CB1AC43" modified="2001-03-01" version="1">MPNSSSSQNLSSQPSIKIRHRLAKKKTIRRRRVDLKCGCSYYLHISCQNHGFSHRGIHYCGSSMEWRVYLEDKQPPIFHDNRTPPTPLSLPSRHNTNANTIQPQPSEGVGDSQSFPELPNLDDFTASDWSFLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW6</accession>
    <name>Q9DHW6_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication enhancer</fullName>
            <shortName evidence="4">REn</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">c3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Increases viral DNA accumulation. Enhances infectivity and symptom expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homooligomer. Interacts with the replication-associated protein (REP). Interacts with host proliferating cell nuclear antigen (PCNA). Interacts with host retinoblastoma-related protein 1 (RBR1), and may thereby deregulate the host cell cycle. Oligomerization and interaction with PCNA are necessary for optimal replication enhancement.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the geminiviridae replication enhancer protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620295.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991149"/>
    <dbReference type="KEGG" id="vg:991149"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000657">
        <property type="entry name" value="Gemini_AL3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01407">
        <property type="entry name" value="Gemini_AL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00231">
        <property type="entry name" value="GEMCOATAL3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC18823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="134" mass="15950" checksum="F2A159B1C467461F" modified="2001-03-01" version="1">MDSRTGEYITADQAWNGVFTWKINNPLYFTITEHHQRPFLCRHDIIQMQIRFNHNLRRALGIHKAFLNFRIWTTLRPQTGRFLRVFRTQVLKYLDMLGVISLNLVVRAVSHVLENVLIGTIDVQEKHVIKFDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW7</accession>
    <name>Q9DHW7_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Capsid protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">coat protein</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the geminiviridae capsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620294.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9DHW7"/>
    <dbReference type="GeneID" id="991151"/>
    <dbReference type="KEGG" id="vg:991151"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039615">
        <property type="term" value="C:T=1 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075732">
        <property type="term" value="P:viral penetration into host nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000650">
        <property type="entry name" value="Gem_coat_AR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000263">
        <property type="entry name" value="GV_A/BR1_coat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029053">
        <property type="entry name" value="Viral_coat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00844">
        <property type="entry name" value="Gemini_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00224">
        <property type="entry name" value="GEMCOATAR1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00223">
        <property type="entry name" value="GEMCOATARBR1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1140">T=1 icosahedral capsid protein</keyword>
    <keyword evidence="5 7" id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword evidence="7" id="KW-0946">Virion</keyword>
    <keyword evidence="7" id="KW-1160">Virus entry into host cell</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC18822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="257" mass="29982" checksum="FC4DE397A68215DD" modified="2001-03-01" version="1">MAKRTGDILISTPVSKVRRKLNFDSPYMSRAVAPTVLVTSKRRQWANRPMYRKPRMYRMYRSPDVPKGCEGPCKVQSYEQRDDVKHTGIVRCVSDVTRGSGITHRVGKRFCVKSIYILGKIWMDENIKKQNHTNQVMFFLVRDRRPNGSSPLDFGQVFNMFDNEPSTATVKNDLRDRFQVMRKFHATVVGGPSGMKEQVLVKRFFRVYNHVVYNHQEAAKYENHTENAMYVYGVTHFSNPVYATLKIRIYFYDSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q9DHW8</accession>
    <name>Q9DHW8_9GEMI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein V2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">v2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Watermelon chlorotic stunt virus</name>
        <dbReference type="NCBI Taxonomy" id="35341"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Repensiviricetes</taxon>
            <taxon>Geplafuvirales</taxon>
            <taxon>Geminiviridae</taxon>
            <taxon>Begomovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="1998-10" db="EMBL/GenBank/DDBJ databases">
            <title>Molecular characterisation of the bipartite begomovirus, watermelon chlorotic stunt virus.</title>
            <authorList>
                <person name="Briddon R.W."/>
                <person name="Banks G."/>
                <person name="Bedford I.D."/>
                <person name="Pinner M.S."/>
                <person name="Jones P."/>
                <person name="Markham P.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Through its interaction with host SGS3, acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Interacts with host SGS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Host cytoplasm</location>
            <location evidence="2 6">Host perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the geminiviridae protein AV2/V2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ012081">
        <property type="protein sequence ID" value="CAC18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_620293.1">
        <property type="nucleotide sequence ID" value="NC_003708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="991153"/>
    <dbReference type="KEGG" id="vg:991153"/>
    <dbReference type="Proteomes" id="UP000217275">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044220">
        <property type="term" value="C:host cell perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019048">
        <property type="term" value="P:modulation by virus of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060967">
        <property type="term" value="P:negative regulation of gene silencing by RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002511">
        <property type="entry name" value="Gemini_V2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005159">
        <property type="entry name" value="WCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01524">
        <property type="entry name" value="Gemini_V2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03716">
        <property type="entry name" value="WCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0941">Suppressor of RNA silencing</keyword>
    <feature type="domain" description="WCCH" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000217275"/>
        </source>
    </evidence>
    <sequence length="119" mass="13631" checksum="5C0724DAAB44542A" modified="2001-03-01" version="1">MWDPLLNDFPESVHGFRCMLAVKYLQAVESTYEPNTLGHELIRDLILVLRARDYGEANRRYSHFHSRFEGSSKTELRQPLHEPCCCPHCPGHKQASTMGQQAHVSKAQDVQDVSKPRCP</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>